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SAR library for RA 189160

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Rebecka Isaksson edited this page Dec 18, 2024 · 1 revision

Please go to Researchers involved for a list of researchers who contributed to this work

In the process of looking for a negative control for our covalent compound, we stumbled upon a compound (RA-189160) that showed very good antiviral activity along with a favorable therapeutic window. While this compound is explored in other assays the following first expansion of the compound has been put together. Part of the molecule are changed to explore which motifs can be modified and hopefully with and indication of which adjustments are allowed.

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Next steps

  • Test RA-189160 for DENV NS5/RdRp activity
  • Establish synthetic protocols to explore the compound further

Story So Far

General information

Rules of Participation

Origins of this Project

People contributing to this project

Other Repositories

Chemistry

High-throughput screening campaign

Assay interference

Expansion - acrylamide

Expansion ‐ fluorosulfonyl

Contribution via Open Call

SAR library for RA-20649

Nelson-Lohmann library

SAR library for RA-189160

Biology

Tools and assays

DENV Rdrp

Sources of Data

Sources of Data

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