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Mention gene conversion as a mechanism that creates LOH
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Sascha Meiers committed Mar 13, 2018
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Expand Up @@ -169,8 +169,10 @@ \subsection{Molecular mechanisms underlying the formation of SVs}
repair is not always faithful, though, sometimes leading to the formation of
\acp{sv}. A major mechanism of \sv formation employs the homologous
recombination machinery, which uses homologous sequence (from the sister
chromatid) as a template to repair a break. However, given the repetitive
nature of the human genome, homology might not only be present at the
chromatid) as a template to repair a break. Homologous recombination during
meiosis can lead to \emph{gene conversion}, which results in the replacement of
an allele via the second allele (\loh). However, given the repetitive nature of
the human genome, homology (or near identical sequence) might not only be present at the
respective locus but also in other, non-allelic loci. This \emph{\acf{nahr}}
can create various types of \acp{sv}, including deletions, duplications,
inversions and even translocation, depending on position and orientation of the
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