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Discussion: inital draft of equity concerns (work in progress) #552
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@@ -11,8 +11,42 @@ In this review, we seek to explain the scientific rationale underlying these tec | |||||||
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### Concerns about Equity in Healthcare | ||||||||
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Scientific and medical research broadly is shaped by a number of biases. | ||||||||
Some concerns include how clinical trials recruit and operate. | ||||||||
The objective of the paper is to compile and synthesis literature on the disease COVID-19. | ||||||||
To accurately and completely discuss this pandemic, health disparities and bias need to be addressed, so that the information is applicable to all. | ||||||||
Bias in medicine can be characterized as when a physician and/or patient “others” an individual in a healthcare setting, oftentimes this occurs when a person looks or acts differently. | ||||||||
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For "looks or acts differently," is there a specific definition for differently that they use in the literature you looked at? Otherwise, I actually think you could stick with just the first sentence. |
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By being self-aware of our own implicit biases, one can work towards equality. | ||||||||
There was a problem hiding this comment. Choose a reason for hiding this commentThe reason will be displayed to describe this comment to others. Learn more. This is definitely a good point (because it applies to science as well as clinical trials and medical treatments), but I would suggest maybe reframing a little to bring it back to the context of this review (e.g., COVID-19 outcomes and medical research).
There was a problem hiding this comment. Choose a reason for hiding this commentThe reason will be displayed to describe this comment to others. Learn more. I agree about the reframing -- these are good points, but they sound like a letter to the editor rather than a research paper. Discussing racial bias in a review about COVID-19 is necessary because of the differential death rates observed, but putting a complete discussion of bias in the medical profession in a review about COVID-19 isn't feasible -- it just sounds like a digression. |
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<!--Risk of comorbid health conditions associated with more severe outcomes may be influenced by long-term damage caused by chronic stress related to traumatic social experiences [@doi:10.1007/s12170-013-0338-5], perhaps mediated by cardiovascular risk factors [@doi:10.1101/2020.05.10.20097253], although the effects of chronic stress have not yet been researched in the specific case of COVID-19 disparities.--> | ||||||||
The population of the inhabitants or humans on Earth is approximately 7.8 billion people. | ||||||||
The myriad of cultures, languages, and environments differentiate the population into subpopulations with varying beliefs, values, and point of views. | ||||||||
However, the preponderance of the academic discourse made public is produced by western, educated, industrialized, rich and democratic, or WIERD, individuals, which comprise 12 percent of world occupants. | ||||||||
While there is not much empirical data on the representativeness of WEIRD individuals within mankind, this blatant disparity brings forth the notion of bias in science, for researchers generalize their discoveries to the entire human population. | ||||||||
There was a problem hiding this comment. Choose a reason for hiding this commentThe reason will be displayed to describe this comment to others. Learn more. Let's try to figure out what the clinical trials terminology for this is -- I think WEIRD is mostly used in psych. This seems like it might be helpful: https://acsjournals.onlinelibrary.wiley.com/doi/full/10.1002/cncr.23157 There was a problem hiding this comment. Choose a reason for hiding this commentThe reason will be displayed to describe this comment to others. Learn more. I have a hard time seeing how some of this applies to COVID-19 specifically. Are you concerned that there aren't enough COVID-19 trials in some regions of the world? If so, it would be much more informative in this context to support that claim with data or citations, instead of just making sweeping and unsupported statements about how science in general is biased. I'm not saying that you are wrong in what you're saying, but I think that in a review written by many people it's necessary to work extra hard to keep from becoming a collection of forty brief essays by forty different people. And most importantly, I think that it is very important that these claims need to have citations to back them up. |
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The purpose of acknowledging the implicit biases within academia is to provide an appropriate lens for readers to interpret the information. | ||||||||
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Humans, more specifically researchers and scientists, ought to examine their ability to distinguish between evolutionary aspects of psychology and cultural aspects of psychology. | ||||||||
Evolutionary theory suggests that all human psychology behaves in a similar manner. | ||||||||
Thus, researchers extrapolate the idea that diversity (race, gender, and etc.) lacks importance in how they conduct their studies. | ||||||||
For instance, many psychology studies utilize university college students enrolled in a psychology course for their surveys or as subjects. | ||||||||
These biased results from these studies portray a false representation of global human behavior. | ||||||||
An individual's environment and culture are paramount to their principles and perception, which gravely affect behavior and, consequently, scientific data. | ||||||||
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The role of bias in information and its implications goes beyond psychological studies as it is applicable to medicine: how diseases and illnesses are diagnosed, the varying degrees of treatment, and who are in clinical trials. | ||||||||
The racism within medicine is critical to understanding how practitioners and researchers’ bias negatively affects health outcomes. | ||||||||
There is a misconception that African-American individuals have thicker skin and exorbitant pain tolerance in comparison to other demographics. | ||||||||
As a result, African-Americans can be misdiagnosed and be given incorrect prescriptions. | ||||||||
The glomerular filtration rate (GFR) is a tool used to measure a specific protein in the blood, which is an indicator of kidney function. | ||||||||
This sophisicalted equation inputs data, such as, weight, age, sex, serum levels of creatinine, and race, to obtain a result. | ||||||||
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There was a problem hiding this comment. Choose a reason for hiding this commentThe reason will be displayed to describe this comment to others. Learn more. I think that it is important to have citations for these statements, in the context of a review article. I also would recommend changing the word "exorbitant" because I don't think it actually means "high" in general; I think it means "overly expensive" which doesn't make sense here. Maybe you mean "extreme" or just "unusually high"? There was a problem hiding this comment. Choose a reason for hiding this commentThe reason will be displayed to describe this comment to others. Learn more. Yes, I forgot to add citations. |
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Black individuals have a higher racial adjustment factor than that of other races. | ||||||||
Thus, with similar factors as a white person, for instance, a Black person would have greater kidney function, leading to more kidney complications to reach the threshold of kidney disease. | ||||||||
In addition to misdiagnosis, participation in clinical trials by African-Americans is disproportionately lower than that of caucasians, even in diseases which [African-Americans] are more susceptible.When there is equal opportunity to participate in clinical trials, there is an insignificant difference between racial groups. | ||||||||
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There was a problem hiding this comment. Choose a reason for hiding this commentThe reason will be displayed to describe this comment to others. Learn more. I think these claims need to be made a little clearer, and definitely need to be supported with citations. There was a problem hiding this comment. Choose a reason for hiding this commentThe reason will be displayed to describe this comment to others. Learn more. For Black Americans specifically, you can find some citations in the links from this paper: |
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Why are certain racial groups disproportionately being infected with Covid-19. | ||||||||
There was a problem hiding this comment. Choose a reason for hiding this commentThe reason will be displayed to describe this comment to others. Learn more. It sounded like this might be a section heading? Apologies if I misunderstood!
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There was a problem hiding this comment. Choose a reason for hiding this commentThe reason will be displayed to describe this comment to others. Learn more. I think I understand your point. In the question I posed affected would be better than infected? |
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Studies suggest that discussions between doctors and patients impact whether or not a physician offers joining a clinical trial. | ||||||||
The results of the studies convey that physicians’ visits with African-Americans were shorter and provided less information about clinical trials than that of whites. | ||||||||
Some of the reasons for this disparity are lack of awareness and education, mistrust in healthcare professionals, and lack of health insurance because otherwise there should be no disparity. | ||||||||
These studies show that both physicians and patients have a bias or misinformation that can affect health outcomes. | ||||||||
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There is little to no data on the ongoing clinical trials for COVID-19, however, one can presume that African-Americans and other racial minorities are not obtaining equitable access to clinical trials for a disease that research has shown disproportionately affects them. | ||||||||
While much of the research on health disparities and bias are inconclusive, humans, specifically scientists in medicine, need to make an effort to think more global and be more inclusive with their clinical trials to aid the health outcomes of all demographics. | ||||||||
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<!--From #460: Risk of comorbid health conditions associated with more severe outcomes may be influenced by long-term damage caused by chronic stress related to traumatic social experiences [@doi:10.1007/s12170-013-0338-5], perhaps mediated by cardiovascular risk factors [@doi:10.1101/2020.05.10.20097253], although the effects of chronic stress have not yet been researched in the specific case of COVID-19 disparities.--> | ||||||||
There was a problem hiding this comment. Choose a reason for hiding this commentThe reason will be displayed to describe this comment to others. Learn more. @tlukan, this was suggested previously by another contributor. Do you think it would be an interesting topic to expand on alongside what you are developing? Previously I wanted to study allostatic load (long-term effects of chronic stress), so I have definitely got some materials I put together that I could use to make an outline in case it would be helpful. I do think your clinical trial participation point probably has the most direct effect on what we're analyzing, though. There was a problem hiding this comment. Choose a reason for hiding this commentThe reason will be displayed to describe this comment to others. Learn more. I do agree that we should say that it's important to make sure that people in racial minorities and people in lower-income jobs have ample opportunity to be represented in trials, especially since they are at the highest risk. But I think it would be better to present this specifically in the context of the implications for COVID-19, because the paper as a whole isn't about the sociology of medicine. There was a problem hiding this comment. Choose a reason for hiding this commentThe reason will be displayed to describe this comment to others. Learn more. Thank you @dziakj1 I will make the point more specific to covid-19. But much information about racial bias in covid-19 clinical trails isn't available to my knowledge, so should I present prior research on other diseases and allude to the fact that covid-19 is applicable to these issues? Since the paper is about covid I should be general in discussing prior research? |
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