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v0.2.2

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@brentp brentp released this 19 Nov 19:57
· 54 commits to master since this release

NOTE that this release requires a very recent version of mosdepth

v0.2.2

  • huge reduction in number of discordant reads sent to lumpy for some problematic samples.
    this is work by @ernfrid which reduces lumpy runtime for all cases and dramatically lowers
    it for cases that were previously problematic due to large numbers of discordant reads.
    On our Genome in a Bottle test sample, this drops the number of discordant reads
    from 1,434,810 to 332,384; a 4.3 fold reduction
    while leaving the final smoove output unchanged
    except for 2 BNDs that were removed. This reduction in reads will be even more dramatic
    in problematic samples.
  • switch to use svtyper>=0.7.0 with --max_ci_dist parameter. To avoid this set:
    export SMOOVE_NO_MAX_CI=xx # any value will work; however, it's higly recommended
    to use as-is.
  • cnvnator changes and filtering. (still requires github.com/brentp/CNVnator fork).
  • bugfix for case when no output directory was specified.
  • use mosdepth with --fast-mode NOTE this requires the latest version of mosdepth (0.2.4 or greater)