v0.2.2
NOTE that this release requires a very recent version of mosdepth
v0.2.2
- huge reduction in number of discordant reads sent to lumpy for some problematic samples.
this is work by @ernfrid which reduces lumpy runtime for all cases and dramatically lowers
it for cases that were previously problematic due to large numbers of discordant reads.
On our Genome in a Bottle test sample, this drops the number of discordant reads
from 1,434,810 to 332,384; a 4.3 fold reduction while leaving the final smoove output unchanged
except for 2 BNDs that were removed. This reduction in reads will be even more dramatic
in problematic samples. - switch to use svtyper>=0.7.0 with
--max_ci_dist
parameter. To avoid this set:
export SMOOVE_NO_MAX_CI=xx
# any value will work; however, it's higly recommended
to use as-is. - cnvnator changes and filtering. (still requires github.com/brentp/CNVnator fork).
- bugfix for case when no output directory was specified.
- use mosdepth with --fast-mode NOTE this requires the latest version of mosdepth (0.2.4 or greater)