crmSubpathway: Identify cancer-related metabolic subpathways

Description: The crmSubpathway package is a systematic biological tool to identify cancer-related metabolic subpathways. The main capabilities of this tool are as follows:

1. This function uses the k-clique algorithm to split the metabolic pathways in the KEGG database into metabolic subpathways.
2. A stable metabolic subpathway activity matrix is constructed by GSVA or ssGSEA methods.
3. Cancer-related metabolic subpathways are identified through differential analysis.
4. Visualization

Installation:

library(devtools)
install_github("hanjunwei-lab/crmSubpathway")
use：library(crmSubpathway)

The crmSubpathway is published in Frontiers in Oncology. Please cite the following article when using crmSubpathway:
Xudong Han, Donghua Wang, Qingfei Kong and Junwei Han. Inference of Subpathway Activity Profiles Reveals Metabolism Abnormal Subpathway Regions in Glioblastoma Multiforme. Frontiers in Oncology. https://doi.org/10.3389/fonc.2020.01549.