Fix Duplicate Stearoyl-CoA Beta-Oxidation Reactions (#820)

* fix: removed MAR00776 and MAR00778 from YAML file * feat: added appropriate refs for MAR03115-8 since refs from MAR00776 weren't appropriate * chore: merged annotations for MAR00776 with those for MAR03115-8 in reactions.tsv and moved MAR00776 to deprecatedReactions.tsv * chore: merged annotations for MAR00778 with those for MAR03116-MAR03146 in reactions.tsv and moved MAR00778 to deprecatedReactions.tsv * fix: indentation error in YAML file * fix: removed incorrect MetaNetX IDs for MAR03117 and MAR03118 * chore: add macaw test result * chore: add macaw test result --------- Co-authored-by: Eduard Kerkhoven <eduardk@chalmers.se> Co-authored-by: Devlin-Moyer <Devlin-Moyer@users.noreply.github.com> Co-authored-by: edkerk <edkerk@users.noreply.github.com>
SysBioChalmers · Dec 17, 2024 · ccc8b29 · ccc8b29
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diff --git a/data/deprecatedIdentifiers/deprecatedReactions.tsv b/data/deprecatedIdentifiers/deprecatedReactions.tsv
@@ -300,3 +300,5 @@ rxns	rxnKEGGID	rxnBiGGID	rxnEHMNID	rxnHepatoNET1ID	rxnREACTOMEID	rxnRecon3DID	rx
 "MAR08745"	""	"THMMPtm"	""	""	""	""	"MNXR104822"	"HMR_8745"	"RCR20669"	""	0	""	""	"HMR_8745"
 "MAR08747"	""	"THMPPtm"	""	""	""	""	"MNXR104824"	"HMR_8747"	"RCR20670"	""	0	""	""	"HMR_8747"
 "MAR07799"	""	"ATPasel"	""	""	""	""	"MNXR96136"	"HMR_7799"	"RCR20334"	""	0	""	""	"HMR_7799"
+"MAR00776"	""	"FAOXC180"	""	""	""	"FAOXC180"	"MNXR99313"	""	""	""	0	""	""	"FAOXC180"
+"MAR00778"	""	"FAOXC1811601m"	""	""	""	"FAOXC1811601m"	"MNXR99315"	""	""	""	0	""	""	"FAOXC1811601m"
diff --git a/data/testResults/README.md b/data/testResults/README.md
@@ -2,7 +2,7 @@
 
 The file here contains results from the [MACAW](https://github.com/Devlin-Moyer/macaw) `dead_end_test` and `duplicate_test` tests, and from cell-line specific gene essentiality prediction based on the [Hart _et al._ (2015)](https://doi.org/10.1016/j.cell.2015.11.015) dataset.
 
-The test results shown here were obtained by the GitHub Actions run in **PR #933** (MACAW) and **PR #675** (gene essentiality), and will be updated by any subsequent PR. Summary results are shown as a comment in the corresponding PR.
+The test results shown here were obtained by the GitHub Actions run in **PR #820** (MACAW) and **PR #675** (gene essentiality), and will be updated by any subsequent PR. Summary results are shown as a comment in the corresponding PR.
 
 ### MACAW: `dead_end_test`
 Looks for metabolites in Human-GEM that can only be produced by all reactions they participate in or only consumed, then identifies all reactions that are prevented from sustaining steady-state fluxes because of each of these dead-end metabolites. The simplest case of a dead-end metabolite is one that only participates in a single reaction. Also flags all reversible reactions that can only carry fluxes in a single direction because one of their metabolites can either only be consumed or only be produced by all other reactions it participates in.

diff --git a/data/testResults/macaw_results.csv b/data/testResults/macaw_results.csv
@@ -8250,9 +8250,7 @@ MAR00759,4 MAM01597x + 4 MAM01802x + 4 MAM02040x + 4 MAM02552x + MAM02678x --> 4
 MAR00764,MAM00051m + 4 MAM01597m + 3 MAM01802m + 4 MAM02040m + 4 MAM02552m --> 4 MAM01261m + 3 MAM01803m + 4 MAM02039m + 4 MAM02553m + MAM02644m,ok,ok,ok,ok,N/A
 MAR00772,4 MAM01597m + 3 MAM01802m + 4 MAM02040m + 4 MAM02552m + MAM02677m --> 4 MAM01261m + 3 MAM01803m + 4 MAM02039m + 4 MAM02553m + MAM02644m,ok,ok,ok,ok,N/A
 MAR00774,7 MAM01597m + 7 MAM01802m + 7 MAM02040m + MAM02101m + 7 MAM02552m --> 7 MAM01261m + 7 MAM01803m + 7 MAM02039m + 7 MAM02553m + MAM02774m,ok,ok,ok,ok,N/A
-MAR00776,MAM01597m + MAM01802m + MAM02040m + MAM02552m + MAM02941m --> MAM01261m + MAM01803m + MAM02039m + MAM02553m + MAM02678m,ok,ok,ok,ok,N/A
 MAR00777,MAM01597x + MAM01802x + MAM02040x + MAM02552x + MAM02941x --> MAM01261x + MAM01803x + MAM02039x + MAM02553x + MAM02678x,ok,ok,ok,ok,N/A
-MAR00778,MAM00057m + 5 MAM01597m + 4 MAM01802m + 5 MAM02040m + 5 MAM02552m --> 5 MAM01261m + 4 MAM01803m + 5 MAM02039m + 5 MAM02553m + MAM02644m,ok,ok,ok,ok,N/A
 MAR00780,5 MAM01597m + 4 MAM01802m + 5 MAM02040m + 5 MAM02552m + MAM03791m --> 5 MAM01261m + 4 MAM01803m + 5 MAM02039m + 5 MAM02553m + MAM02644m,ok,ok,ok,ok,N/A
 MAR00784,5 MAM01597m + 4 MAM01802m + 5 MAM02040m + 5 MAM02552m + MAM02647m --> 5 MAM01261m + 4 MAM01803m + 5 MAM02039m + 5 MAM02553m + MAM02644m,ok,ok,ok,ok,N/A
 MAR00785,5 MAM01597m + 3 MAM01802m + 5 MAM02040m + MAM02391m + 5 MAM02552m --> 5 MAM01261m + 3 MAM01803m + 5 MAM02039m + 5 MAM02553m + MAM02644m,ok,ok,ok,ok,N/A

diff --git a/model/Human-GEM.yml b/model/Human-GEM.yml
@@ -118350,7 +118350,7 @@
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "1.3.8.7;1.3.8.8;1.3.8.9;1.3.99.-"
-      - references: ""
+      - references: "PMID:20490924"
       - subsystem:
           - "Beta oxidation of even-chain fatty acids (mitochondrial)"
       - confidence_score: 0
@@ -118367,7 +118367,7 @@
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "4.2.1.17"
-      - references: ""
+      - references: "PMID:20490924"
       - subsystem:
           - "Beta oxidation of even-chain fatty acids (mitochondrial)"
       - confidence_score: 0
@@ -118386,7 +118386,7 @@
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "1.1.1.35;1.1.1.211"
-      - references: ""
+      - references: "PMID:20490924"
       - subsystem:
           - "Beta oxidation of even-chain fatty acids (mitochondrial)"
       - confidence_score: 0
@@ -118404,7 +118404,7 @@
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "2.3.1.16;1.1.1.211"
-      - references: ""
+      - references: "PMID:20490924"
       - subsystem:
           - "Beta oxidation of even-chain fatty acids (mitochondrial)"
       - confidence_score: 0
@@ -221482,30 +221482,6 @@
       - subsystem:
           - "Fatty acid oxidation"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR00776"
-      - name: "Beta Oxidation of Long Chain Fatty Acid"
-      - metabolites: !!omap
-          - MAM01261m: 1
-          - MAM01597m: -1
-          - MAM01802m: -1
-          - MAM01803m: 1
-          - MAM02039m: 1
-          - MAM02040m: -1
-          - MAM02552m: -1
-          - MAM02553m: 1
-          - MAM02678m: 1
-          - MAM02941m: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000117054 or ENSG00000122971"
-      - rxnNotes: ""
-      - rxnFrom: "Recon3D"
-      - eccodes: "1.3.99.3"
-      - references: "PMID:2565344;PMID:3035565"
-      - subsystem:
-          - "Fatty acid oxidation"
-      - confidence_score: 0
     - !!omap
       - id: "MAR00777"
       - name: "Beta Oxidation of Long Chain Fatty Acid"
@@ -221530,30 +221506,6 @@
       - subsystem:
           - "Fatty acid oxidation"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR00778"
-      - name: "Beta Oxidation Fatty Acid"
-      - metabolites: !!omap
-          - MAM00057m: -1
-          - MAM01261m: 5
-          - MAM01597m: -5
-          - MAM01802m: -4
-          - MAM01803m: 4
-          - MAM02039m: 5
-          - MAM02040m: -5
-          - MAM02552m: -5
-          - MAM02553m: 5
-          - MAM02644m: 1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000117054 or ENSG00000122971"
-      - rxnNotes: ""
-      - rxnFrom: "Recon3D"
-      - eccodes: "4.2.1.74"
-      - references: ""
-      - subsystem:
-          - "Fatty acid oxidation"
-      - confidence_score: 0
     - !!omap
       - id: "MAR00780"
       - name: "Beta Oxidation Fatty Acid"

diff --git a/model/reactions.tsv b/model/reactions.tsv
@@ -2624,26 +2624,26 @@ rxns	rxnKEGGID	rxnBiGGID	rxnEHMNID	rxnHepatoNET1ID	rxnREACTOMEID	rxnRecon3DID	rx
 "MAR03112"	""	""	""	""	""	"HMR_3112"	""	"HMR_3112"	"RCR12626"	""	0	""	""	"HMR_3112"
 "MAR03113"	""	""	""	""	""	"HMR_3113"	""	"HMR_3113"	"RCR12627"	""	0	""	""	"HMR_3113"
 "MAR03114"	""	""	""	""	""	"HMR_3114"	""	"HMR_3114"	"RCR12628"	""	0	""	""	"HMR_3114"
-"MAR03115"	""	""	""	""	""	"HMR_3115"	""	"HMR_3115"	"RCR12629"	""	0	""	""	"HMR_3115"
-"MAR03116"	"R07760"	""	""	""	""	"HMR_3116"	""	"HMR_3116"	"RCR12630"	""	0	"RHEA:35349"	"RHEA:35347"	"HMR_3116"
-"MAR03117"	""	""	""	""	""	"HMR_3117"	""	"HMR_3117"	"RCR12631"	""	0	"RHEA:35276"	"RHEA:35275"	"HMR_3117"
-"MAR03118"	""	""	""	""	""	"HMR_3118"	""	"HMR_3118"	"RCR12632"	""	0	""	""	"HMR_3118"
-"MAR03121"	"R01279"	"r0310"	""	""	"R-HSA-77299"	"HMR_3121;r0310"	"MNXR125070"	"HMR_3121"	"RCR12633"	""	0	""	"RHEA:30747"	"HMR_3121;r0310;MAR02035"
-"MAR03122"	"R04738"	""	"R04738X"	"r0716"	""	"r0716"	"MNXR105372;MNXR97892"	"HMR_3122"	"RCR12634"	""	0	""	"RHEA:31163"	"HMR_3122"
-"MAR03123"	"R04737"	""	"R04737X"	"r0714"	""	"r0714"	"MNXR100548;MNXR105371"	"HMR_3123"	"RCR12635"	""	0	""	"RHEA:31159"	"HMR_3123"
-"MAR03125"	"R03991"	""	"R03991X"	"r0653"	""	"r0653"	"MNXR95203"	"HMR_3125"	"RCR12636"	""	0	""	"RHEA:18161"	"HMR_3125"
-"MAR03128"	"R03990"	"r1449"	""	""	"R-HSA-77274"	"HMR_3128;r1449"	"MNXR95300"	"HMR_3128"	"RCR12637"	""	0	""	"RHEA:28358"	"HMR_3128;r1449;MAR02370"
-"MAR03129"	"R04740"	""	"R04740X"	"r0720"	""	"r0720"	"MNXR105373;MNXR97891"	"HMR_3129"	"RCR12638"	""	0	""	"RHEA:31171"	"HMR_3129"
-"MAR03130"	"R04739"	""	"R04739X"	"r0718"	""	"r0718"	"MNXR100547"	"HMR_3130"	"RCR12639"	""	0	""	"RHEA:31167"	"HMR_3130"
-"MAR03132"	"R03858"	""	"R03858X"	"r0639"	""	"r0639"	"MNXR95201"	"HMR_3132"	"RCR12640"	""	0	""	"RHEA:31091"	"HMR_3132"
-"MAR03135"	"R03857"	"r1447"	""	""	"R-HSA-77263"	"HMR_3135;r1447"	"MNXR95299"	"HMR_3135"	"RCR12641"	""	0	""	"RHEA:31039"	"HMR_3135;r1447;MAR02367"
-"MAR03136"	"R04170"	"r1446"	"R04170X"	"r0660"	""	"r0660;r1446"	"MNXR97890"	"HMR_3136"	"RCR12642"	""	0	""	"RHEA:31075"	"HMR_3136;r1446;MAR02366"
-"MAR03137"	"R04741"	""	"R04741X"	"r0722"	""	"r0722"	"MNXR100546"	"HMR_3137"	"RCR12643"	""	0	""	"RHEA:31179"	"HMR_3137"
-"MAR03139"	"R04742"	""	"R04742X"	"r0724"	""	"r0724"	"MNXR95199;MNXR95200"	"HMR_3139"	"RCR12644"	""	0	"RHEA:31185"	"RHEA:31183"	"HMR_3139"
-"MAR03142"	"R04754"	"r1451;FAOXC10C10OHm;FAOXC10080m"	""	""	"R-HSA-77345"	"HMR_3142;r1451;FAOXC10C10OHm;FAOXC10C8m"	"MNXR109095"	"HMR_3142"	"RCR12645"	""	0	""	"RHEA:28354"	"HMR_3142;r1451;MAR02373;FAOXC10C10OHm;MAR05019;FAOXC10C8m;MAR05024"
-"MAR03143"	"R04744"	"FAOXC10C10OHm;FAOXC101C8m;FAOXC10080m"	"R04744X"	"r0728"	""	"r0728;HMR_3422;FAOXC10C10OHm;FAOXC101C8m;FAOXC10C8m"	"MNXR97889"	"HMR_3143;HMR_3422"	"RCR12646;RCR12667"	""	0	""	"RHEA:31191"	"HMR_3143;HMR_3422;MAR03422;FAOXC10C10OHm;MAR05019;FAOXC101C8m;MAR04967;FAOXC10C8m;MAR05024"
-"MAR03144"	"R04743"	"FAOXC101C8m;FAOXC10080m"	"R04743X"	"r0726"	""	"r0726;HMR_3422;FAOXC101C8m;FAOXC10C8m"	"MNXR100545"	"HMR_3144;HMR_3422"	"RCR12647;RCR12667"	""	0	""	"RHEA:31187"	"HMR_3144;HMR_3422;MAR03422;FAOXC101C8m;MAR04967;FAOXC10C8m;MAR05024"
-"MAR03146"	"R03778"	"FAOXC101C8m;FAOXC10080m"	"R03778X"	"r0634"	""	"r0634;HMR_3422;FAOXC101C8m;FAOXC10C8m"	"MNXR95198"	"HMR_3146;HMR_3422"	"RCR12648;RCR12667"	""	0	"RHEA:31089"	"RHEA:31087"	"HMR_3146;HMR_3422;MAR03422;FAOXC101C8m;MAR04967;FAOXC10C8m;MAR05024"
+"MAR03115"	""	"FAOXC180"	""	""	""	"HMR_3115;FAOXC180"	""	"HMR_3115"	"RCR12629"	""	0	""	""	"HMR_3115;FAOXC180;MAR00776"
+"MAR03116"	"R07760"	"FAOXC180;FAOXC1811601m"	""	""	""	"HMR_3116;FAOXC180;FAOXC1811601m"	""	"HMR_3116"	"RCR12630"	""	0	"RHEA:35349"	"RHEA:35347"	"HMR_3116;FAOXC180;MAR00776;FAOXC1811601m;MAR00778"
+"MAR03117"	""	"FAOXC180;FAOXC1811601m"	""	""	""	"HMR_3117;FAOXC180;FAOXC1811601m"	""	"HMR_3117"	"RCR12631"	""	0	"RHEA:35276"	"RHEA:35275"	"HMR_3117;FAOXC180;MAR00776;FAOXC1811601m;MAR00778"
+"MAR03118"	""	"FAOXC180;FAOXC1811601m"	""	""	""	"HMR_3118;FAOXC180;FAOXC1811601m"	""	"HMR_3118"	"RCR12632"	""	0	""	""	"HMR_3118;FAOXC180;MAR00776;FAOXC1811601m;MAR00778"
+"MAR03121"	"R01279"	"r0310;FAOXC1811601m"	""	""	"R-HSA-77299"	"HMR_3121;r0310;FAOXC1811601m"	"MNXR125070"	"HMR_3121"	"RCR12633"	""	0	""	"RHEA:30747"	"HMR_3121;r0310;MAR02035;FAOXC1811601m;MAR00778"
+"MAR03122"	"R04738"	"FAOXC1811601m"	"R04738X"	"r0716"	""	"r0716;FAOXC1811601m"	"MNXR105372;MNXR97892"	"HMR_3122"	"RCR12634"	""	0	""	"RHEA:31163"	"HMR_3122;FAOXC1811601m;MAR00778"
+"MAR03123"	"R04737"	"FAOXC1811601m"	"R04737X"	"r0714"	""	"r0714;FAOXC1811601m"	"MNXR100548;MNXR105371"	"HMR_3123"	"RCR12635"	""	0	""	"RHEA:31159"	"HMR_3123;FAOXC1811601m;MAR00778"
+"MAR03125"	"R03991"	"FAOXC1811601m"	"R03991X"	"r0653"	""	"r0653;FAOXC1811601m"	"MNXR95203"	"HMR_3125"	"RCR12636"	""	0	""	"RHEA:18161"	"HMR_3125;FAOXC1811601m;MAR00778"
+"MAR03128"	"R03990"	"r1449;FAOXC1811601m"	""	""	"R-HSA-77274"	"HMR_3128;r1449;FAOXC1811601m"	"MNXR95300"	"HMR_3128"	"RCR12637"	""	0	""	"RHEA:28358"	"HMR_3128;r1449;MAR02370;FAOXC1811601m;MAR00778"
+"MAR03129"	"R04740"	"FAOXC1811601m"	"R04740X"	"r0720"	""	"r0720;FAOXC1811601m"	"MNXR105373;MNXR97891"	"HMR_3129"	"RCR12638"	""	0	""	"RHEA:31171"	"HMR_3129;FAOXC1811601m;MAR00778"
+"MAR03130"	"R04739"	"FAOXC1811601m"	"R04739X"	"r0718"	""	"r0718;FAOXC1811601m"	"MNXR100547"	"HMR_3130"	"RCR12639"	""	0	""	"RHEA:31167"	"HMR_3130;FAOXC1811601m;MAR00778"
+"MAR03132"	"R03858"	"FAOXC1811601m"	"R03858X"	"r0639"	""	"r0639;FAOXC1811601m"	"MNXR95201"	"HMR_3132"	"RCR12640"	""	0	""	"RHEA:31091"	"HMR_3132;FAOXC1811601m;MAR00778"
+"MAR03135"	"R03857"	"r1447;FAOXC1811601m"	""	""	"R-HSA-77263"	"HMR_3135;r1447;FAOXC1811601m"	"MNXR95299"	"HMR_3135"	"RCR12641"	""	0	""	"RHEA:31039"	"HMR_3135;r1447;MAR02367;FAOXC1811601m;MAR00778"
+"MAR03136"	"R04170"	"r1446;FAOXC1811601m"	"R04170X"	"r0660"	""	"r0660;r1446;FAOXC1811601m"	"MNXR97890"	"HMR_3136"	"RCR12642"	""	0	""	"RHEA:31075"	"HMR_3136;r1446;MAR02366;FAOXC1811601m;MAR00778"
+"MAR03137"	"R04741"	"FAOXC1811601m"	"R04741X"	"r0722"	""	"r0722;FAOXC1811601m"	"MNXR100546"	"HMR_3137"	"RCR12643"	""	0	""	"RHEA:31179"	"HMR_3137;FAOXC1811601m;MAR00778"
+"MAR03139"	"R04742"	"FAOXC1811601m"	"R04742X"	"r0724"	""	"r0724;FAOXC1811601m"	"MNXR95199;MNXR95200"	"HMR_3139"	"RCR12644"	""	0	"RHEA:31185"	"RHEA:31183"	"HMR_3139;FAOXC1811601m;MAR00778"
+"MAR03142"	"R04754"	"r1451;FAOXC10C10OHm;FAOXC10080m;FAOXC1811601m"	""	""	"R-HSA-77345"	"HMR_3142;r1451;FAOXC10C10OHm;FAOXC10C8m;FAOXC1811601m"	"MNXR109095"	"HMR_3142"	"RCR12645"	""	0	""	"RHEA:28354"	"HMR_3142;r1451;MAR02373;FAOXC10C10OHm;MAR05019;FAOXC10C8m;MAR05024;FAOXC1811601m;MAR00778"
+"MAR03143"	"R04744"	"FAOXC10C10OHm;FAOXC101C8m;FAOXC10080m;FAOXC1811601m"	"R04744X"	"r0728"	""	"r0728;HMR_3422;FAOXC10C10OHm;FAOXC101C8m;FAOXC10C8m;FAOXC1811601m"	"MNXR97889"	"HMR_3143;HMR_3422"	"RCR12646;RCR12667"	""	0	""	"RHEA:31191"	"HMR_3143;HMR_3422;MAR03422;FAOXC10C10OHm;MAR05019;FAOXC101C8m;MAR04967;FAOXC10C8m;MAR05024;FAOXC1811601m;MAR00778"
+"MAR03144"	"R04743"	"FAOXC101C8m;FAOXC10080m;FAOXC1811601m"	"R04743X"	"r0726"	""	"r0726;HMR_3422;FAOXC101C8m;FAOXC10C8m;FAOXC1811601m"	"MNXR100545"	"HMR_3144;HMR_3422"	"RCR12647;RCR12667"	""	0	""	"RHEA:31187"	"HMR_3144;HMR_3422;MAR03422;FAOXC101C8m;MAR04967;FAOXC10C8m;MAR05024;FAOXC1811601m;MAR00778"
+"MAR03146"	"R03778"	"FAOXC101C8m;FAOXC10080m;FAOXC1811601m"	"R03778X"	"r0634"	""	"r0634;HMR_3422;FAOXC101C8m;FAOXC10C8m;FAOXC1811601m"	"MNXR95198"	"HMR_3146;HMR_3422"	"RCR12648;RCR12667"	""	0	"RHEA:31089"	"RHEA:31087"	"HMR_3146;HMR_3422;MAR03422;FAOXC101C8m;MAR04967;FAOXC10C8m;MAR05024;FAOXC1811601m;MAR00778"
 "MAR03149"	"R03777"	"r1448;FAOXC8C6m;FAOXC80"	""	""	"R-HSA-77338"	"HMR_3149;r1448;FAOXC6C8m;FAOXC80;HMR_3422"	"MNXR95304"	"HMR_3149;HMR_3422"	"RCR12649;RCR12667"	""	0	""	"RHEA:30943"	"HMR_3149;r1448;MAR02369;FAOXC8C6m;MAR06329;FAOXC80;MAR01009;HMR_3422;MAR03422"
 "MAR03150"	"R04746"	"FAOXC8C6m;FAOXC80"	"R04746M"	"r0731"	""	"r0731;FAOXC8C6m;FAOXC80;HMR_3422"	"MNXR97888"	"HMR_3150;HMR_3422"	"RCR12650;RCR12667"	""	0	""	"RHEA:31199"	"HMR_3150;FAOXC6C8m;MAR06329;FAOXC80;MAR01009;HMR_3422;MAR03422"
 "MAR03151"	"R04745"	"FAOXC8C6m;FAOXC80"	"R04745M"	"r0730"	""	"r0730;FAOXC8C6m;FAOXC80;HMR_3422"	"MNXR100544"	"HMR_3151;HMR_3422"	"RCR12651;RCR12667"	""	0	""	"RHEA:31195"	"HMR_3151;FAOXC8C6m;MAR06329;FAOXC80;MAR01009;HMR_3422;MAR03422"
@@ -8249,9 +8249,7 @@ rxns	rxnKEGGID	rxnBiGGID	rxnEHMNID	rxnHepatoNET1ID	rxnREACTOMEID	rxnRecon3DID	rx
 "MAR00764"	""	"FAOXC161802m"	""	""	""	"FAOXC161802m"	"MNXR99301"	""	""	""	0	""	""	"FAOXC161802m"
 "MAR00772"	""	"FAOXC16180m"	""	""	""	"FAOXC16180m"	"MNXR99302"	""	""	""	0	""	""	"FAOXC16180m"
 "MAR00774"	""	"FAOXC170m"	""	""	""	"FAOXC170m"	"MNXR99312"	""	""	""	0	""	""	"FAOXC170m"
-"MAR00776"	""	"FAOXC180"	""	""	""	"FAOXC180"	"MNXR99313"	""	""	""	0	""	""	"FAOXC180"
 "MAR00777"	""	"FAOXC180x"	""	""	""	"FAOXC180x"	"MNXR99314"	""	""	""	0	""	""	"FAOXC180x"
-"MAR00778"	""	"FAOXC1811601m"	""	""	""	"FAOXC1811601m"	"MNXR99315"	""	""	""	0	""	""	"FAOXC1811601m"
 "MAR00780"	""	"FAOXC1811602m"	""	""	""	"FAOXC1811602m"	"MNXR99316"	""	""	""	0	""	""	"FAOXC1811602m"
 "MAR00784"	""	"FAOXC1811603m"	""	""	""	"FAOXC1811603m"	"MNXR99317"	""	""	""	0	""	""	"FAOXC1811603m"
 "MAR00785"	""	"FAOXC182806m"	""	""	""	"FAOXC182806m"	"MNXR99321"	""	""	""	0	""	""	"FAOXC182806m"