Model selection #42
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I wasn't sure if I should put this as a separate discussion issue or add it to the list of topics for Friday, but decided to go with a separate issue because we already covered the topic today.
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There is not really a need for model selection in the fixed effects when you are analyzing a factorial experiment -- because main effects and interactions are uncorrelated in a balanced design. Missing data destroys the balancing but as long as they are in the usual range, this will not make much of a difference. If you have very many factors (like in the mrk17 example) and no hypothesis about higher-order interactions, it is also defensible to remove interactions top down. There is a very convenient formula syntax for this. In the example:
F*P*Q*lQ*lT
is the full factorial. You can write this also as:(F+P+Q+lQ+lT)^5
. To keep all but the five-factor interaction you write:(F+P+Q+lQ+lT)^4
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