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Fixes #2621. Fixes #2622 #2630

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merged 3 commits into from
May 20, 2023
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Fixes #2621. Fixes #2622 #2630

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5e0c423
Fixes #2621. Fixes #2622
msevestre May 19, 2023
705a562
Fixes #2621. Fixes #2622
msevestre May 19, 2023
dc990a8
Fixes #2621
msevestre May 20, 2023
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10 changes: 5 additions & 5 deletions src/PKSim.Core/Services/HIDiseaseStateImplementation.cs
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@Yuri05 Yuri05 May 19, 2023 •
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As far as I understood the discussion in #2621 the value origin for the blood flow factors must be changed now from Edginton to Johnson?

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Ha ha this is correct. Eagle eye Juri

Original file line number Diff line number Diff line change
Expand Up @@ -36,14 +36,14 @@ private static HIFactors createFactors(double forA, double forB, double forC) =>
};

private static readonly HIFactors _portalFlowScalingFactor = createFactors(0.4, 0.36, 0.04);
private static readonly HIFactors _hepaticFlowScalingFactor = createFactors(1.3, 2.3, 3.4);
private static readonly HIFactors _hepaticFlowScalingFactor = createFactors(1.61, 2.34, 5.29);
private static readonly HIFactors _hepaticVolumeScalingFactor = createFactors(0.69, 0.55, 0.28);
private static readonly HIFactors _renalFlowScalingFactor = createFactors(0.88, 0.65, 0.48);
private static readonly HIFactors _cardiacIndexScalingFactor = createFactors(1.11, 1.27, 1.36);
private static readonly HIFactors _gfrScalingFactor = createFactors(1, 0.7, 0.36);
private static readonly HIFactors _albuminScalingFactor = createFactors(0.81, 0.68, 0.5);
private static readonly HIFactors _agpScalingFactor = createFactors(0.6, 0.56, 0.3);
private static readonly HIFactors _hematocritScalingFactor = createFactors(0.92, 0.88, 0.83);
private static readonly HIFactors _hematocritScalingFactor = createFactors(0.86, 0.822, 0.778);
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In #2621 (comment) HCT-Scalefactor for A is 0.866


private static readonly Cache<string, HIFactors> _moleculeScalingFactorEdginton = new()
{
Expand Down Expand Up @@ -148,8 +148,8 @@ private void updateBloodFlowsAndVolumes(Individual individual, Action<ParameterU
var Q_portal = portalOrgans.Sum(bloodFlow);
var Q_other = otherOrgans.Sum(bloodFlow);
var Q_brain = bloodFlow(BRAIN);
var Q_liver = bloodFlow(LIVER);
var Q_kidney = bloodFlow(KIDNEY);
var Q_liver = bloodFlow(LIVER);

var portal_factor = _portalFlowScalingFactor[score];
var liver_factor = _hepaticFlowScalingFactor[score];
Expand All @@ -168,8 +168,8 @@ private void updateBloodFlowsAndVolumes(Individual individual, Action<ParameterU

//retrieve the scaling factor based on publication and github entry
//see https://github.com/Open-Systems-Pharmacology/Forum/discussions/1341
var otherOrganFactor = (ci_factor * (Q_other + Q_portal + Q_kidney + Q_liver + Q_brain) - (Q_brain + Q_portal * portal_factor + Q_liver_HI * liver_factor + Q_kidney * kidney_factor)) / Q_other;
otherOrgans.Each(x => updateBloodFlowSpec(x, otherOrganFactor));
var otherOrganDiseaseFactor = (ci_factor * (Q_other + Q_portal + Q_kidney + Q_liver + Q_brain) - (Q_brain + Q_portal * portal_factor + Q_liver_HI * liver_factor + Q_kidney * kidney_factor)) / Q_other;
otherOrgans.Each(x => updateBloodFlowSpec(x, otherOrganDiseaseFactor));
}

private Action<string, double> updateBloodFlowSpecDef(Action<ParameterUpdate> updateParameterFunc, IContainer organism) => (organName, factor) =>
Expand Down
117 changes: 60 additions & 57 deletions tests/PKSim.Tests/IntegrationTests/HIDiseaseStateImplementationSpecs.cs
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Original file line number Diff line number Diff line change
Expand Up @@ -71,7 +71,7 @@ protected override void Context()
_individual.Organism.Organ(SKIN).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit = 8.65;
_individual.Organism.Organ(KIDNEY).Parameter(GFR_SPEC).ValueInDisplayUnit = 20;
//HCT parameter is a discrete distribution parameter. In order to update the value properly, we need to set the mean value
_individual.Organism.Parameter(HCT).DowncastTo<IDistributedParameter>().MeanParameter.Value = 0.43;
_individual.Organism.Parameter(HCT).DowncastTo<IDistributedParameter>().MeanParameter.Value = 0.45;
}

protected override void Because()
Expand Down Expand Up @@ -126,44 +126,45 @@ protected override void Context()
[Observation]
public void should_return_the_expected_values_for_specific_blood_flows()
{
_individual.Organism.Organ(STOMACH).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(15.44, 1e-2);
_individual.Organism.Organ(SMALL_INTESTINE).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(35.91, 1e-2);
_individual.Organism.Organ(LARGE_INTESTINE).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(25.22, 1e-2);
_individual.Organism.Organ(SPLEEN).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(32.04, 1e-2);
_individual.Organism.Organ(PANCREAS).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(13.67, 1e-2);
_individual.Organism.Organ(LIVER).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(23.32, 1e-2);
_individual.Organism.Organ(KIDNEY).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(266.38, 1e-2);
_individual.Organism.Organ(BONE).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(4.63, 1e-2);
_individual.Organism.Organ(FAT).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(3.67, 1e-2);
_individual.Organism.Organ(GONADS).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(13.58, 1e-2);
_individual.Organism.Organ(HEART).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(105.10, 1e-2);
_individual.Organism.Organ(MUSCLE).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(5.77, 1e-2);
_individual.Organism.Organ(SKIN).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(14.58, 1e-2);
_individual.Organism.Organ(STOMACH).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(15.44, 1e-3);
_individual.Organism.Organ(SMALL_INTESTINE).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(35.91, 1e-3);
_individual.Organism.Organ(LARGE_INTESTINE).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(25.22, 1e-3);
_individual.Organism.Organ(SPLEEN).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(32.04, 1e-3);
_individual.Organism.Organ(PANCREAS).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(13.67, 1e-3);
_individual.Organism.Organ(LIVER).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(28.88, 1e-3);
_individual.Organism.Organ(KIDNEY).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(266.38, 1e-3);
//for other blood flow, we have some rounding error due to that we are calculating with 2 digits in the excel file
_individual.Organism.Organ(BONE).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(4.539, 1e-2);
_individual.Organism.Organ(FAT).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(3.598, 1e-2);
_individual.Organism.Organ(GONADS).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(13.28, 1e-2);
_individual.Organism.Organ(HEART).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(102.71, 1e-2);
_individual.Organism.Organ(MUSCLE).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(5.63, 1e-2);
_individual.Organism.Organ(SKIN).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(14.25, 1e-2);
}

[Observation]
public void should_return_the_expected_values_for_ontogeny_factor_albumin_and_glycoprotein()
{
_individual.Organism.Parameter(ONTOGENY_FACTOR_ALBUMIN).ValueInDisplayUnit.ShouldBeEqualTo(0.81, 1e-2);
_individual.Organism.Parameter(ONTOGENY_FACTOR_AGP).ValueInDisplayUnit.ShouldBeEqualTo(0.6, 1e-2);
_individual.Organism.Parameter(ONTOGENY_FACTOR_ALBUMIN).ValueInDisplayUnit.ShouldBeEqualTo(0.81, 1e-3);
_individual.Organism.Parameter(ONTOGENY_FACTOR_AGP).ValueInDisplayUnit.ShouldBeEqualTo(0.6, 1e-3);
}

[Observation]
public void should_return_the_expected_values_for_gfr_spec()
{
_individual.Organism.Organ(KIDNEY).Parameter(GFR_SPEC).ValueInDisplayUnit.ShouldBeEqualTo(20 * 1, 1e-2);
_individual.Organism.Organ(KIDNEY).Parameter(GFR_SPEC).ValueInDisplayUnit.ShouldBeEqualTo(20 * 1, 1e-3);
}

[Observation]
public void should_return_the_expected_values_for_hct()
{
_individual.Organism.Parameter(HCT).ValueInDisplayUnit.ShouldBeEqualTo(0.395, 1e-2);
_individual.Organism.Parameter(HCT).ValueInDisplayUnit.ShouldBeEqualTo(0.387, 1e-3);
}

[Observation]
public void should_return_the_expected_values_for_volumes()
{
_individual.Organism.Organ(LIVER).Parameter(VOLUME).ValueInDisplayUnit.ShouldBeEqualTo(1.64, 1e-2);
_individual.Organism.Organ(LIVER).Parameter(VOLUME).ValueInDisplayUnit.ShouldBeEqualTo(1.642, 1e-3);
}
}

Expand All @@ -178,7 +179,7 @@ protected override void Context()
[Observation]
public void should_return_the_expected_values_for_reference_concentration()
{
_molecule.ReferenceConcentration.Value.ShouldBeEqualTo(5 * 0.89, 1e-2);
_molecule.ReferenceConcentration.Value.ShouldBeEqualTo(5 * 0.89, 1e-3);
}
}

Expand All @@ -193,44 +194,45 @@ protected override void Context()
[Observation]
public void should_return_the_expected_values_for_specific_blood_flows()
{
_individual.Organism.Organ(STOMACH).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(13.90, 1e-2);
_individual.Organism.Organ(SMALL_INTESTINE).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(32.32, 1e-2);
_individual.Organism.Organ(LARGE_INTESTINE).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(22.70, 1e-2);
_individual.Organism.Organ(SPLEEN).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(28.84, 1e-2);
_individual.Organism.Organ(PANCREAS).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(12.30, 1e-2);
_individual.Organism.Organ(LIVER).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(41.26, 1e-2);
_individual.Organism.Organ(KIDNEY).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(196.76, 1e-2);
_individual.Organism.Organ(BONE).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(6.04, 1e-2);
_individual.Organism.Organ(FAT).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(4.79, 1e-2);
_individual.Organism.Organ(GONADS).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(17.69, 1e-2);
_individual.Organism.Organ(HEART).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(136.86, 1e-2);
_individual.Organism.Organ(MUSCLE).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(7.51, 1e-2);
_individual.Organism.Organ(SKIN).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(18.99, 1e-2);
_individual.Organism.Organ(STOMACH).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(13.90, 1e-3);
_individual.Organism.Organ(SMALL_INTESTINE).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(32.32, 1e-3);
_individual.Organism.Organ(LARGE_INTESTINE).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(22.70, 1e-3);
_individual.Organism.Organ(SPLEEN).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(28.84, 1e-3);
_individual.Organism.Organ(PANCREAS).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(12.30, 1e-3);
_individual.Organism.Organ(LIVER).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(41.964, 1e-3);
_individual.Organism.Organ(KIDNEY).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(196.76, 1e-3);
//for other blood flow, we have some rounding error due to that we are calculating with 2 digits in the excel file
_individual.Organism.Organ(BONE).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(6.03, 1e-2);
_individual.Organism.Organ(FAT).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(4.78, 1e-2);
_individual.Organism.Organ(GONADS).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(17.66, 1e-2);
_individual.Organism.Organ(HEART).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(136.60, 1e-2);
_individual.Organism.Organ(MUSCLE).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(7.49, 1e-2);
_individual.Organism.Organ(SKIN).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(18.95, 1e-2);
}

[Observation]
public void should_return_the_expected_values_for_ontogeny_factor_albumin_and_glycoprotein()
{
_individual.Organism.Parameter(ONTOGENY_FACTOR_ALBUMIN).ValueInDisplayUnit.ShouldBeEqualTo(0.68, 1e-2);
_individual.Organism.Parameter(ONTOGENY_FACTOR_AGP).ValueInDisplayUnit.ShouldBeEqualTo(0.56, 1e-2);
_individual.Organism.Parameter(ONTOGENY_FACTOR_ALBUMIN).ValueInDisplayUnit.ShouldBeEqualTo(0.68, 1e-3);
_individual.Organism.Parameter(ONTOGENY_FACTOR_AGP).ValueInDisplayUnit.ShouldBeEqualTo(0.56, 1e-3);
}

[Observation]
public void should_return_the_expected_values_for_gfr_spec()
{
_individual.Organism.Organ(KIDNEY).Parameter(GFR_SPEC).ValueInDisplayUnit.ShouldBeEqualTo(20 * 0.7, 1e-2);
_individual.Organism.Organ(KIDNEY).Parameter(GFR_SPEC).ValueInDisplayUnit.ShouldBeEqualTo(20 * 0.7, 1e-3);
}

[Observation]
public void should_return_the_expected_values_for_hct()
{
_individual.Organism.Parameter(HCT).ValueInDisplayUnit.ShouldBeEqualTo(0.378, 1e-2);
_individual.Organism.Parameter(HCT).ValueInDisplayUnit.ShouldBeEqualTo(0.37, 1e-3);
}

[Observation]
public void should_return_the_expected_values_for_volumes()
{
_individual.Organism.Organ(LIVER).Parameter(VOLUME).ValueInDisplayUnit.ShouldBeEqualTo(1.31, 1e-2);
_individual.Organism.Organ(LIVER).Parameter(VOLUME).ValueInDisplayUnit.ShouldBeEqualTo(1.31, 1e-3);
}
}

Expand All @@ -245,7 +247,7 @@ protected override void Context()
[Observation]
public void should_return_the_expected_values_for_reference_concentration()
{
_molecule.ReferenceConcentration.Value.ShouldBeEqualTo(5 * 0.62, 1e-2);
_molecule.ReferenceConcentration.Value.ShouldBeEqualTo(5 * 0.62, 1e-3);
}
}

Expand All @@ -260,44 +262,45 @@ protected override void Context()
[Observation]
public void should_return_the_expected_values_for_specific_blood_flows()
{
_individual.Organism.Organ(STOMACH).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(1.54, 1e-2);
_individual.Organism.Organ(SMALL_INTESTINE).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(3.60, 1e-2);
_individual.Organism.Organ(LARGE_INTESTINE).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(2.52, 1e-2);
_individual.Organism.Organ(SPLEEN).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(3.20, 1e-2);
_individual.Organism.Organ(PANCREAS).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(1.37, 1e-2);
_individual.Organism.Organ(LIVER).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(61.00, 1e-2);
_individual.Organism.Organ(KIDNEY).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(145.30, 1e-2);
_individual.Organism.Organ(BONE).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(7.52, 1e-2);
_individual.Organism.Organ(FAT).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(5.96, 1e-2);
_individual.Organism.Organ(GONADS).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(22.04, 1e-2);
_individual.Organism.Organ(HEART).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(170.50, 1e-2);
_individual.Organism.Organ(MUSCLE).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(9.35, 1e-2);
_individual.Organism.Organ(SKIN).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(23.66, 1e-2);
_individual.Organism.Organ(STOMACH).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(1.544, 1e-3);
_individual.Organism.Organ(SMALL_INTESTINE).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(3.590, 1e-3);
_individual.Organism.Organ(LARGE_INTESTINE).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(2.522, 1e-3);
_individual.Organism.Organ(SPLEEN).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(3.204, 1e-3);
_individual.Organism.Organ(PANCREAS).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(1.367, 1e-3);
_individual.Organism.Organ(LIVER).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(94.933, 1e-3);
_individual.Organism.Organ(KIDNEY).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(145.30, 1e-3);
//for other blood flow, we have some rounding error due to that we are calculating with 2 digits in the excel file
_individual.Organism.Organ(BONE).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(7.26, 1e-2);
_individual.Organism.Organ(FAT).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(5.76, 1e-2);
_individual.Organism.Organ(GONADS).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(21.29, 1e-2);
_individual.Organism.Organ(HEART).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(164.66, 1e-2);
_individual.Organism.Organ(MUSCLE).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(9.02, 1e-2);
_individual.Organism.Organ(SKIN).Parameter(SPECIFIC_BLOOD_FLOW_RATE).ValueInDisplayUnit.ShouldBeEqualTo(22.85, 1e-2);
}

[Observation]
public void should_return_the_expected_values_for_ontogeny_factor_albumin_and_glycoprotein()
{
_individual.Organism.Parameter(ONTOGENY_FACTOR_ALBUMIN).ValueInDisplayUnit.ShouldBeEqualTo(0.5, 1e-2);
_individual.Organism.Parameter(ONTOGENY_FACTOR_AGP).ValueInDisplayUnit.ShouldBeEqualTo(0.3, 1e-2);
_individual.Organism.Parameter(ONTOGENY_FACTOR_AGP).ValueInDisplayUnit.ShouldBeEqualTo(0.3, 1e-3);
}

[Observation]
public void should_return_the_expected_values_for_gfr_spec()
{
_individual.Organism.Organ(KIDNEY).Parameter(GFR_SPEC).ValueInDisplayUnit.ShouldBeEqualTo(20 * 0.36, 1e-2);
_individual.Organism.Organ(KIDNEY).Parameter(GFR_SPEC).ValueInDisplayUnit.ShouldBeEqualTo(20 * 0.36, 1e-3);
}

[Observation]
public void should_return_the_expected_values_for_hct()
{
_individual.Organism.Parameter(HCT).ValueInDisplayUnit.ShouldBeEqualTo(0.357, 1e-2);
_individual.Organism.Parameter(HCT).ValueInDisplayUnit.ShouldBeEqualTo(0.35, 1e-3);
}

[Observation]
public void should_return_the_expected_values_for_volumes()
{
_individual.Organism.Organ(LIVER).Parameter(VOLUME).ValueInDisplayUnit.ShouldBeEqualTo(0.67, 1e-2);
_individual.Organism.Organ(LIVER).Parameter(VOLUME).ValueInDisplayUnit.ShouldBeEqualTo(0.666, 1e-3);
}
}

Expand All @@ -312,7 +315,7 @@ protected override void Context()
[Observation]
public void should_return_the_expected_values_for_reference_concentration()
{
_molecule.ReferenceConcentration.Value.ShouldBeEqualTo(5 * 0.32, 1e-2);
_molecule.ReferenceConcentration.Value.ShouldBeEqualTo(5 * 0.32, 1e-3);
}
}

Expand Down
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