TxDb.Hsapiens.NCBI.hg38.MANE

Description

A TxDb object to be used for genetic analysis in R. The object suited to be used as any TxDb object which can be explored with different Bioconductor packages, including GenomicFeatures. TxDb.Hsapiens.NCBI.hg38.MANE contains transcript information from the Matched Annotation from NCBI and EMBL-EBI (MANE) project which collects information from both the NCBI RefSeq and the EMBL-EBi Ensembl/GENCODE projects. The dataset contains information from representative protein coding transcripts and combines both transcript and gene identifiers.

Resources

The .gtf file used to create the package was downloaded from NCBI and was made into a TxDb object using txdbmaker.

The MANE project is described in Morales et al. 2022, Nature.

Installation

The package is installed directly from GitHub using devtools

if (!require(devtools)) install.packages('devtools')
library(devtools)

devtools::install_github("CTrierMaansson/TxDb.Hsapiens.NCBI.hg38.MANE")
TxDb_MANE <- TxDb.Hsapiens.NCBI.hg38.MANE::TxDb.Hsapiens.NCBI.hg38.MANE

Citation

Please site this package as Maansson, CT. (2024). TxDb.Hsapiens.NCBI.hg38.MANE (Version 1.0.0) [Computer software]. https://github.com/CTrierMaansson/TxDb.Hsapiens.NCBI.hg38.MANE