diff --git a/extensions/agroal/runtime/src/main/java/io/quarkus/agroal/runtime/DataSources.java b/extensions/agroal/runtime/src/main/java/io/quarkus/agroal/runtime/DataSources.java
index 4996ee0ce328f4..10415d485313d9 100644
--- a/extensions/agroal/runtime/src/main/java/io/quarkus/agroal/runtime/DataSources.java
+++ b/extensions/agroal/runtime/src/main/java/io/quarkus/agroal/runtime/DataSources.java
@@ -140,6 +140,10 @@ public AgroalDataSource getDataSource(String dataSourceName) {
         return dataSource;
     }
 
+    public boolean isDataSourceActive(String dataSourceName) {
+        return getDataSourceIfActiveOrNull(dataSourceName) != null;
+    }
+
     public Optional<AgroalDataSource> getDataSourceIfActive(String dataSourceName) {
         return Optional.ofNullable(getDataSourceIfActiveOrNull(dataSourceName));
     }
diff --git a/extensions/flyway/runtime/src/main/java/io/quarkus/flyway/runtime/FlywayDataSourceRuntimeConfig.java b/extensions/flyway/runtime/src/main/java/io/quarkus/flyway/runtime/FlywayDataSourceRuntimeConfig.java
index 726ada0de89fd2..2e9d9aa3dd35ee 100644
--- a/extensions/flyway/runtime/src/main/java/io/quarkus/flyway/runtime/FlywayDataSourceRuntimeConfig.java
+++ b/extensions/flyway/runtime/src/main/java/io/quarkus/flyway/runtime/FlywayDataSourceRuntimeConfig.java
@@ -25,8 +25,8 @@ public static FlywayDataSourceRuntimeConfig defaultConfig() {
     /**
      * Flag to activate/deactivate Flyway for a specific datasource at runtime.
      */
-    @ConfigItem(defaultValue = "true")
-    public boolean active = true;
+    @ConfigItem(defaultValueDocumentation = "'true' if the datasource is active; 'false' otherwise")
+    public Optional<Boolean> active = Optional.empty();
 
     /**
      * The maximum number of retries when attempting to connect to the database.
diff --git a/extensions/flyway/runtime/src/main/java/io/quarkus/flyway/runtime/FlywayRecorder.java b/extensions/flyway/runtime/src/main/java/io/quarkus/flyway/runtime/FlywayRecorder.java
index 71d8b011cf18d1..2a61b6f7cd9f8c 100644
--- a/extensions/flyway/runtime/src/main/java/io/quarkus/flyway/runtime/FlywayRecorder.java
+++ b/extensions/flyway/runtime/src/main/java/io/quarkus/flyway/runtime/FlywayRecorder.java
@@ -106,7 +106,9 @@ public void doStartActions(String dataSourceName) {
         FlywayDataSourceRuntimeConfig flywayDataSourceRuntimeConfig = config.getValue()
                 .getConfigForDataSourceName(dataSourceName);
 
-        if (!config.getValue().getConfigForDataSourceName(dataSourceName).active) {
+        if (!flywayDataSourceRuntimeConfig.active
+                // If not specified explicitly, Flyway is active when the datasource itself is active.
+                .orElseGet(() -> Arc.container().instance(DataSources.class).get().isDataSourceActive(dataSourceName))) {
             return;
         }
 
diff --git a/extensions/liquibase/deployment/src/main/java/io/quarkus/liquibase/deployment/LiquibaseProcessor.java b/extensions/liquibase/deployment/src/main/java/io/quarkus/liquibase/deployment/LiquibaseProcessor.java
index 52b2e76afd401a..89e923fdc98872 100644
--- a/extensions/liquibase/deployment/src/main/java/io/quarkus/liquibase/deployment/LiquibaseProcessor.java
+++ b/extensions/liquibase/deployment/src/main/java/io/quarkus/liquibase/deployment/LiquibaseProcessor.java
@@ -303,10 +303,13 @@ ServiceStartBuildItem startLiquibase(LiquibaseRecorder recorder,
             BuildProducer<InitTaskCompletedBuildItem> initializationCompleteBuildItem,
             BuildProducer<JdbcDataSourceSchemaReadyBuildItem> schemaReadyBuildItem) {
 
-        recorder.doStartActions();
+        Set<String> dataSourceNames = getDataSourceNames(jdbcDataSourceBuildItems);
+        for (String dataSourceName : dataSourceNames) {
+            recorder.doStartActions(dataSourceName);
+        }
         // once we are done running the migrations, we produce a build item indicating that the
         // schema is "ready"
-        schemaReadyBuildItem.produce(new JdbcDataSourceSchemaReadyBuildItem(getDataSourceNames(jdbcDataSourceBuildItems)));
+        schemaReadyBuildItem.produce(new JdbcDataSourceSchemaReadyBuildItem(dataSourceNames));
         initializationCompleteBuildItem.produce(new InitTaskCompletedBuildItem("liquibase"));
 
         return new ServiceStartBuildItem("liquibase");
diff --git a/extensions/liquibase/runtime/src/main/java/io/quarkus/liquibase/runtime/LiquibaseRecorder.java b/extensions/liquibase/runtime/src/main/java/io/quarkus/liquibase/runtime/LiquibaseRecorder.java
index d48296e144fb17..3f2e43dcbf6897 100644
--- a/extensions/liquibase/runtime/src/main/java/io/quarkus/liquibase/runtime/LiquibaseRecorder.java
+++ b/extensions/liquibase/runtime/src/main/java/io/quarkus/liquibase/runtime/LiquibaseRecorder.java
@@ -1,20 +1,21 @@
 package io.quarkus.liquibase.runtime;
 
+import java.lang.annotation.Annotation;
+import java.util.Locale;
 import java.util.function.Function;
 
 import javax.sql.DataSource;
 
-import io.quarkus.datasource.common.runtime.DataSourceUtil;
-import io.quarkus.runtime.configuration.ConfigurationException;
-import jakarta.enterprise.inject.Any;
+import jakarta.enterprise.inject.Default;
 import jakarta.enterprise.inject.UnsatisfiedResolutionException;
 
 import io.quarkus.agroal.runtime.DataSources;
 import io.quarkus.agroal.runtime.UnconfiguredDataSource;
 import io.quarkus.arc.Arc;
-import io.quarkus.arc.InjectableInstance;
 import io.quarkus.arc.InstanceHandle;
 import io.quarkus.arc.SyntheticCreationalContext;
+import io.quarkus.datasource.common.runtime.DataSourceUtil;
+import io.quarkus.liquibase.LiquibaseDataSource.LiquibaseDataSourceLiteral;
 import io.quarkus.liquibase.LiquibaseFactory;
 import io.quarkus.runtime.RuntimeValue;
 import io.quarkus.runtime.annotations.Recorder;
@@ -42,7 +43,8 @@ public LiquibaseFactory apply(SyntheticCreationalContext<LiquibaseFactory> conte
                         throw DataSourceUtil.dataSourceNotConfigured(dataSourceName);
                     }
                 } catch (RuntimeException e) {
-                    throw new ConfigurationException(String.format("Unable to find datasource '%s' for Liquibase: %s",
+                    throw new UnsatisfiedResolutionException(String.format(Locale.ROOT,
+                            "Unable to find datasource '%s' for Liquibase: %s",
                             dataSourceName, e.getMessage()), e);
                 }
 
@@ -52,49 +54,53 @@ public LiquibaseFactory apply(SyntheticCreationalContext<LiquibaseFactory> conte
         };
     }
 
-    public void doStartActions() {
+    public void doStartActions(String dataSourceName) {
         if (!config.getValue().enabled) {
             return;
         }
+        // Liquibase is active when the datasource itself is active.
+        if (!Arc.container().instance(DataSources.class).get().isDataSourceActive(dataSourceName)) {
+            return;
+        }
 
+        InstanceHandle<LiquibaseFactory> liquibaseFactoryHandle = Arc.container().instance(LiquibaseFactory.class,
+                getLiquibaseFactoryQualifier(dataSourceName));
         try {
-            InjectableInstance<LiquibaseFactory> liquibaseFactoryInstance = Arc.container()
-                    .select(LiquibaseFactory.class, Any.Literal.INSTANCE);
-            if (liquibaseFactoryInstance.isUnsatisfied()) {
+            LiquibaseFactory liquibaseFactory = liquibaseFactoryHandle.get();
+            var config = liquibaseFactory.getConfiguration();
+            if (!config.cleanAtStart && !config.migrateAtStart) {
                 return;
             }
-
-            for (InstanceHandle<LiquibaseFactory> liquibaseFactoryHandle : liquibaseFactoryInstance.handles()) {
-                try {
-                    LiquibaseFactory liquibaseFactory = liquibaseFactoryHandle.get();
-                    var config = liquibaseFactory.getConfiguration();
-                    if (!config.cleanAtStart && !config.migrateAtStart) {
-                        continue;
-                    }
-                    try (Liquibase liquibase = liquibaseFactory.createLiquibase()) {
-                        if (config.cleanAtStart) {
-                            liquibase.dropAll();
-                        }
-                        if (config.migrateAtStart) {
-                            var lockService = LockServiceFactory.getInstance()
-                                    .getLockService(liquibase.getDatabase());
-                            lockService.waitForLock();
-                            try {
-                                if (config.validateOnMigrate) {
-                                    liquibase.validate();
-                                }
-                                liquibase.update(liquibaseFactory.createContexts(), liquibaseFactory.createLabels());
-                            } finally {
-                                lockService.releaseLock();
-                            }
+            try (Liquibase liquibase = liquibaseFactory.createLiquibase()) {
+                if (config.cleanAtStart) {
+                    liquibase.dropAll();
+                }
+                if (config.migrateAtStart) {
+                    var lockService = LockServiceFactory.getInstance()
+                            .getLockService(liquibase.getDatabase());
+                    lockService.waitForLock();
+                    try {
+                        if (config.validateOnMigrate) {
+                            liquibase.validate();
                         }
+                        liquibase.update(liquibaseFactory.createContexts(), liquibaseFactory.createLabels());
+                    } finally {
+                        lockService.releaseLock();
                     }
-                } catch (UnsatisfiedResolutionException e) {
-                    //ignore, the DS is not configured
                 }
             }
+        } catch (UnsatisfiedResolutionException e) {
+            //ignore, the DS is not configured
         } catch (Exception e) {
             throw new IllegalStateException("Error starting Liquibase", e);
         }
     }
+
+    private static Annotation getLiquibaseFactoryQualifier(String dataSourceName) {
+        if (DataSourceUtil.isDefault(dataSourceName)) {
+            return Default.Literal.INSTANCE;
+        }
+
+        return LiquibaseDataSourceLiteral.of(dataSourceName);
+    }
 }