diff --git a/CHANGELOG.md b/CHANGELOG.md
index 73cbf542fe..dd61dec1d5 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -4,6 +4,7 @@
 * Python: Added OBJECT IDLETIME command ([#1474](https://github.com/aws/glide-for-redis/pull/1474))
 * Node: Added RENAMENX command ([#1483](https://github.com/aws/glide-for-redis/pull/1483))
 * Python: Added OBJECT REFCOUNT command ([#1485](https://github.com/aws/glide-for-redis/pull/1485))
+* Python: Added RENAMENX command ([#1492](https://github.com/aws/glide-for-redis/pull/1492))
 
 ## 0.4.0 (2024-05-26)
 
diff --git a/python/python/glide/async_commands/core.py b/python/python/glide/async_commands/core.py
index 5d37e80318..d76b0a2c94 100644
--- a/python/python/glide/async_commands/core.py
+++ b/python/python/glide/async_commands/core.py
@@ -511,6 +511,31 @@ async def rename(self, key: str, new_key: str) -> TOK:
             TOK, await self._execute_command(RequestType.Rename, [key, new_key])
         )
 
+    async def renamenx(self, key: str, new_key: str) -> bool:
+        """
+        Renames `key` to `new_key` if `new_key` does not yet exist.
+
+        See https://valkey.io/commands/renamenx for more details.
+
+        Note:
+            When in cluster mode, both `key` and `new_key` must map to the same hash slot.
+
+        Args:
+            key (str): The key to rename.
+            new_key (str): The new key name.
+
+        Returns:
+            bool: True if `key` was renamed to `new_key`, or False if `new_key` already exists.
+
+        Examples:
+            >>> await client.renamenx("old_key", "new_key")
+                True  # "old_key" was renamed to "new_key"
+        """
+        return cast(
+            bool,
+            await self._execute_command(RequestType.RenameNX, [key, new_key]),
+        )
+
     async def delete(self, keys: List[str]) -> int:
         """
         Delete one or more keys from the database. A key is ignored if it does not exist.
diff --git a/python/python/glide/async_commands/transaction.py b/python/python/glide/async_commands/transaction.py
index 4d00ac4375..b4b8f21c8f 100644
--- a/python/python/glide/async_commands/transaction.py
+++ b/python/python/glide/async_commands/transaction.py
@@ -154,6 +154,21 @@ def rename(self: TTransaction, key: str, new_key: str) -> TTransaction:
         """
         return self.append_command(RequestType.Rename, [key, new_key])
 
+    def renamenx(self: TTransaction, key: str, new_key: str) -> TTransaction:
+        """
+        Renames `key` to `new_key` if `new_key` does not yet exist.
+
+        See https://valkey.io/commands/renamenx for more details.
+
+        Args:
+            key (str): The key to rename.
+            new_key (str): The new key name.
+
+        Command response:
+            bool: True if `key` was renamed to `new_key`, or False if `new_key` already exists.
+        """
+        return self.append_command(RequestType.RenameNX, [key, new_key])
+
     def custom_command(self: TTransaction, command_args: List[str]) -> TTransaction:
         """
         Executes a single command, without checking inputs.
diff --git a/python/python/tests/test_async_client.py b/python/python/tests/test_async_client.py
index 88881bfb7c..bb6ab600d7 100644
--- a/python/python/tests/test_async_client.py
+++ b/python/python/tests/test_async_client.py
@@ -1457,6 +1457,30 @@ async def test_rename(self, redis_client: TRedisClient):
                 "{same_slot}" + "non_existing_key", "{same_slot}" + "_rename"
             )
 
+    @pytest.mark.parametrize("cluster_mode", [True, False])
+    @pytest.mark.parametrize("protocol", [ProtocolVersion.RESP2, ProtocolVersion.RESP3])
+    async def test_renamenx(self, redis_client: TRedisClient):
+        key1 = f"{{testKey}}:1-{get_random_string(10)}"
+        key2 = f"{{testKey}}:2-{get_random_string(10)}"
+        key3 = f"{{testKey}}:3-{get_random_string(10)}"
+        non_existing_key = f"{{testKey}}:5-{get_random_string(10)}"
+
+        # Verify that attempting to rename a non-existing key throws an error
+        with pytest.raises(RequestError):
+            assert await redis_client.renamenx(non_existing_key, key1)
+
+        # Test RENAMENX with string values
+        assert await redis_client.set(key1, "key1") == OK
+        assert await redis_client.set(key3, "key3") == OK
+        # Test that RENAMENX can rename key1 to key2 (where key2 does not yet exist)
+        assert await redis_client.renamenx(key1, key2) is True
+        # Verify that key2 now holds the value that was in key1
+        assert await redis_client.get(key2) == "key1"
+        # Verify that RENAMENX doesn't rename key2 to key3, since key3 already exists
+        assert await redis_client.renamenx(key2, key3) is False
+        # Verify that key3 remains unchanged
+        assert await redis_client.get(key3) == "key3"
+
     @pytest.mark.parametrize("cluster_mode", [True, False])
     @pytest.mark.parametrize("protocol", [ProtocolVersion.RESP2, ProtocolVersion.RESP3])
     async def test_exists(self, redis_client: TRedisClient):
@@ -3462,6 +3486,7 @@ async def test_multi_key_command_returns_cross_slot_error(
             redis_client.sinterstore("abc", ["zxy", "lkn"]),
             redis_client.sdiff(["abc", "zxy", "lkn"]),
             redis_client.sdiffstore("abc", ["def", "ghi"]),
+            redis_client.renamenx("abc", "def"),
         ]
 
         if not await check_if_server_version_lt(redis_client, "7.0.0"):
diff --git a/python/python/tests/test_transaction.py b/python/python/tests/test_transaction.py
index 160ed6f0f6..da87ff9600 100644
--- a/python/python/tests/test_transaction.py
+++ b/python/python/tests/test_transaction.py
@@ -95,6 +95,9 @@ async def transaction_test(
     transaction.mget([key, key2])
     args.append([value, value2])
 
+    transaction.renamenx(key, key2)
+    args.append(False)
+
     transaction.incr(key3)
     args.append(1)
     transaction.incrby(key3, 2)