diff --git a/CHANGELOG.md b/CHANGELOG.md
index bd15282fbd..bbf9e3cfd4 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -24,6 +24,7 @@
 * Node: Added XLEN command ([#1555](https://github.com/aws/glide-for-redis/pull/1555))
 * Node: Added ZINTERCARD command ([#1553](https://github.com/aws/glide-for-redis/pull/1553))
 * Python: Added LMPOP and BLMPOP commands ([#1547](https://github.com/aws/glide-for-redis/pull/1547))
+* Python: Added MSETNX command ([#1565](https://github.com/aws/glide-for-redis/pull/1565))
 
 ### Breaking Changes
 * Node: Update XREAD to return a Map of Map ([#1494](https://github.com/aws/glide-for-redis/pull/1494))
diff --git a/python/python/glide/async_commands/core.py b/python/python/glide/async_commands/core.py
index 8f5bd5f192..cfdd9a9bee 100644
--- a/python/python/glide/async_commands/core.py
+++ b/python/python/glide/async_commands/core.py
@@ -733,6 +733,36 @@ async def mset(self, key_value_map: Mapping[str, str]) -> TOK:
             parameters.extend(pair)
         return cast(TOK, await self._execute_command(RequestType.MSet, parameters))
 
+    async def msetnx(self, key_value_map: Mapping[str, str]) -> bool:
+        """
+        Sets multiple keys to values if the key does not exist. The operation is atomic, and if one or
+        more keys already exist, the entire operation fails.
+
+        Note:
+            When in cluster mode, all `keys` must map to the same hash slot.
+
+        See https://valkey.io/commands/msetnx/ for more details.
+
+        Args:
+            key_value_map (Mapping[str, str]): A key-value map consisting of keys and their respective values to set.
+
+        Returns:
+            bool: True if all keys were set. False if no key was set.
+
+        Examples:
+            >>> await client.msetnx({"key1": "value1", "key2": "value2"})
+                True
+            >>> await client.msetnx({"key2": "value4", "key3": "value5"})
+                False
+        """
+        parameters: List[str] = []
+        for pair in key_value_map.items():
+            parameters.extend(pair)
+        return cast(
+            bool,
+            await self._execute_command(RequestType.MSetNX, parameters),
+        )
+
     async def mget(self, keys: List[str]) -> List[Optional[str]]:
         """
         Retrieve the values of multiple keys.
diff --git a/python/python/glide/async_commands/transaction.py b/python/python/glide/async_commands/transaction.py
index 7204bf10c7..939b0c6f9f 100644
--- a/python/python/glide/async_commands/transaction.py
+++ b/python/python/glide/async_commands/transaction.py
@@ -309,6 +309,24 @@ def mset(self: TTransaction, key_value_map: Mapping[str, str]) -> TTransaction:
             parameters.extend(pair)
         return self.append_command(RequestType.MSet, parameters)
 
+    def msetnx(self, key_value_map: Mapping[str, str]) -> bool:
+        """
+        Sets multiple keys to values if the key does not exist. The operation is atomic, and if one or
+        more keys already exist, the entire operation fails.
+
+        See https://valkey.io/commands/msetnx/ for more details.
+
+        Args:
+            key_value_map (Mapping[str, str]): A key-value map consisting of keys and their respective values to set.
+
+        Commands response:
+            bool: True if all keys were set. False if no key was set.
+        """
+        parameters: List[str] = []
+        for pair in key_value_map.items():
+            parameters.extend(pair)
+        return self.append_command(RequestType.MSetNX, parameters)
+
     def mget(self: TTransaction, keys: List[str]) -> TTransaction:
         """
         Retrieve the values of multiple keys.
diff --git a/python/python/tests/test_async_client.py b/python/python/tests/test_async_client.py
index 45d7865087..c2143edae9 100644
--- a/python/python/tests/test_async_client.py
+++ b/python/python/tests/test_async_client.py
@@ -524,6 +524,25 @@ async def test_mset_mget(self, redis_client: TRedisClient):
         keys[-1] = None
         assert mget_res == keys
 
+    @pytest.mark.parametrize("cluster_mode", [True, False])
+    @pytest.mark.parametrize("protocol", [ProtocolVersion.RESP2, ProtocolVersion.RESP3])
+    async def test_msetnx(self, redis_client: TRedisClient):
+        key1 = f"{{key}}-1{get_random_string(5)}"
+        key2 = f"{{key}}-2{get_random_string(5)}"
+        key3 = f"{{key}}-3{get_random_string(5)}"
+        non_existing = get_random_string(5)
+        value = get_random_string(5)
+        key_value_map1 = {key1: value, key2: value}
+        key_value_map2 = {key2: get_random_string(5), key3: value}
+
+        assert await redis_client.msetnx(key_value_map1) is True
+        mget_res = await redis_client.mget([key1, key2, non_existing])
+        assert mget_res == [value, value, None]
+
+        assert await redis_client.msetnx(key_value_map2) is False
+        assert await redis_client.get(key3) is None
+        assert await redis_client.get(key2) == value
+
     @pytest.mark.parametrize("cluster_mode", [True, False])
     @pytest.mark.parametrize("protocol", [ProtocolVersion.RESP2, ProtocolVersion.RESP3])
     async def test_ping(self, redis_client: TRedisClient):
@@ -4183,6 +4202,7 @@ async def test_multi_key_command_returns_cross_slot_error(
             redis_client.blmove(
                 "abc", "zxy", ListDirection.LEFT, ListDirection.LEFT, 1
             ),
+            redis_client.msetnx({"abc": "abc", "zxy": "zyx"}),
         ]
 
         if not await check_if_server_version_lt(redis_client, "7.0.0"):
diff --git a/python/python/tests/test_transaction.py b/python/python/tests/test_transaction.py
index 1d753658e3..458844a593 100644
--- a/python/python/tests/test_transaction.py
+++ b/python/python/tests/test_transaction.py
@@ -103,6 +103,8 @@ async def transaction_test(
 
     transaction.mset({key: value, key2: value2})
     args.append(OK)
+    transaction.msetnx({key: value, key2: value2})
+    args.append(False)
     transaction.mget([key, key2])
     args.append([value, value2])