diff --git a/planner/core/plan_cache_test.go b/planner/core/plan_cache_test.go
index 749519f55b45c..f8510e3b6bd6b 100644
--- a/planner/core/plan_cache_test.go
+++ b/planner/core/plan_cache_test.go
@@ -447,3 +447,22 @@ func TestIssue41032(t *testing.T) {
 	tk.MustQuery(`execute stmt using @a,@b`).Check(testkit.Rows())
 	tk.MustQuery(`select @@last_plan_from_cache`).Check(testkit.Rows("1"))
 }
+
+func TestIssue42150(t *testing.T) {
+	store := testkit.CreateMockStore(t)
+	tk := testkit.NewTestKit(t, store)
+	tk.MustExec(`use test`)
+	tk.MustExec("drop table if exists t1, t2")
+	tk.MustExec("CREATE TABLE `t1` (`c_int` int(11) NOT NULL,  `c_str` varchar(40) CHARACTER SET utf8 COLLATE utf8_bin DEFAULT NULL,  `c_datetime` datetime DEFAULT NULL,  `c_timestamp` timestamp NULL DEFAULT NULL,  `c_double` double DEFAULT NULL,  `c_decimal` decimal(12,6) DEFAULT NULL,  `c_enum` enum('blue','green','red','yellow','white','orange','purple') NOT NULL,  PRIMARY KEY (`c_int`,`c_enum`) /*T![clustered_index] CLUSTERED */,  KEY `c_decimal` (`c_decimal`),  UNIQUE KEY `c_datetime` (`c_datetime`),  UNIQUE KEY `c_timestamp` (`c_timestamp`)) ENGINE=InnoDB DEFAULT CHARSET=utf8mb4 COLLATE=utf8mb4_bin;")
+	tk.MustExec("create table t (a int, b int, primary key(a), key(b))")
+
+	tk.MustExec("prepare stmt from 'select c_enum from t1'")
+	tk.MustExec("execute stmt;")
+	tk.MustExec("execute stmt;")
+	tk.MustQuery("select @@last_plan_from_cache").Check(testkit.Rows("1"))
+
+	tk.MustExec("prepare st from 'select a from t use index(b)'")
+	tk.MustExec("execute st")
+	tk.MustExec("execute st")
+	tk.MustQuery("select @@last_plan_from_cache").Check(testkit.Rows("1"))
+}