diff --git a/Marlin/src/inc/SanityCheck.h b/Marlin/src/inc/SanityCheck.h
index 4c598a991ed7..9ec17b28089e 100644
--- a/Marlin/src/inc/SanityCheck.h
+++ b/Marlin/src/inc/SanityCheck.h
@@ -4329,6 +4329,17 @@ static_assert(_PLUS_TEST(3), "DEFAULT_MAX_ACCELERATION values must be positive."
   #error "SDSUPPORT, BINARY_FILE_TRANSFER, and CUSTOM_FIRMWARE_UPLOAD are required for custom upload."
 #endif
 
+/**
+ * Direct Stepping requirements
+ */
+#if ENABLED(DIRECT_STEPPING)
+  #if ENABLED(CPU_32_BIT)
+    #error "Direct Stepping is not supported on 32-bit boards."
+  #elif !IS_FULL_CARTESIAN
+    #error "Direct Stepping is incompatible with enabled kinematics."
+  #endif
+#endif
+
 /**
  * Input Shaping requirements
  */