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Motif scaffolding a dimer with symmetry #188

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nedru004 opened this issue Jan 9, 2025 · 0 comments
Open

Motif scaffolding a dimer with symmetry #188

nedru004 opened this issue Jan 9, 2025 · 0 comments

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@nedru004
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nedru004 commented Jan 9, 2025

I am interested in using RFdiffusion to redesign a signaling protein that is a dimer. I want to use the binding motif from each protein in the dimer and symmetrically redesign the rest of each protein as a homodimer. Is this possible to do? When I add symmetry it makes two pairs of protein dimers far apart from each other. I attached an image of a dimer that I want to keep the red motif and redesign the rest of the protein as a dimer.
dimer_test

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