diff --git a/CHANGELOG.md b/CHANGELOG.md
index f26e8a6b796..5d68860295d 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -2,6 +2,10 @@
 
 - Update Elastic-Charts to version 13.0.0 and updated the theme object accordingly ([#2381](https://github.com/elastic/eui/pull/2381))
 
+**Bug fixes**
+
+- Fix `EuiSelectable` to accept programmatic updates to its `options` prop ([#2390](https://github.com/elastic/eui/pull/2390)) 
+
 ## [`14.4.0`](https://github.com/elastic/eui/tree/v14.4.0)
 
 - Migrate `EuiEmptyPrompt`and `EuiCard` to TS ([#2387](https://github.com/elastic/eui/pull/2387))
diff --git a/src-docs/src/views/selectable/selectable_search.tsx b/src-docs/src/views/selectable/selectable_search.tsx
index 0d780caa96f..e94c755e1c3 100644
--- a/src-docs/src/views/selectable/selectable_search.tsx
+++ b/src-docs/src/views/selectable/selectable_search.tsx
@@ -1,5 +1,7 @@
 import React, { Component, Fragment } from 'react';
 
+import { EuiButtonEmpty } from '../../../../src/components/button';
+
 import { EuiSelectable } from '../../../../src/components/selectable';
 import { Option } from '../../../../src/components/selectable/types';
 import { Options } from './data';
@@ -23,20 +25,33 @@ export default class extends Component<{}, { options: Option[] }> {
     const { options } = this.state;
 
     return (
-      <EuiSelectable
-        searchable
-        searchProps={{
-          'data-test-subj': 'selectableSearchHere',
-        }}
-        options={options}
-        onChange={this.onChange}>
-        {(list, search) => (
-          <Fragment>
-            {search}
-            {list}
-          </Fragment>
-        )}
-      </EuiSelectable>
+      <Fragment>
+        <EuiButtonEmpty
+          onClick={() => {
+            this.setState({
+              options: Options.map(option => ({
+                ...option,
+                checked: undefined,
+              })),
+            });
+          }}>
+          Deselect all
+        </EuiButtonEmpty>
+        <EuiSelectable
+          searchable
+          searchProps={{
+            'data-test-subj': 'selectableSearchHere',
+          }}
+          options={options}
+          onChange={this.onChange}>
+          {(list, search) => (
+            <Fragment>
+              {search}
+              {list}
+            </Fragment>
+          )}
+        </EuiSelectable>
+      </Fragment>
     );
   }
 }
diff --git a/src/components/selectable/selectable.tsx b/src/components/selectable/selectable.tsx
index 7eb1d8354ca..86ba38155c9 100644
--- a/src/components/selectable/selectable.tsx
+++ b/src/components/selectable/selectable.tsx
@@ -148,6 +148,27 @@ export class EuiSelectable extends Component<
     };
   }
 
+  static getDerivedStateFromProps(
+    nextProps: EuiSelectableProps,
+    prevState: EuiSelectableState
+  ) {
+    const { options } = nextProps;
+    const { activeOptionIndex, searchValue } = prevState;
+
+    const matchingOptions = getMatchingOptions(options, searchValue);
+
+    const stateUpdate = { visibleOptions: matchingOptions, activeOptionIndex };
+
+    if (
+      activeOptionIndex != null &&
+      activeOptionIndex >= matchingOptions.length
+    ) {
+      stateUpdate.activeOptionIndex = -1;
+    }
+
+    return stateUpdate;
+  }
+
   hasActiveOption = () => {
     return this.state.activeOptionIndex != null;
   };