setup.py

from setuptools import setup
try: # for pip >= 10
    from pip._internal.req import parse_requirements
except ImportError: # for pip <= 9.0.3
    from pip.req import parse_requirements


# parse_requirements() returns generator of pip.req.InstallRequirement objects
install_reqs = parse_requirements("requirements.in", session=False)

# reqs is a list of requirement
# e.g. ['django==1.5.1', 'mezzanine==1.4.6']
reqs = [str(ir.req) for ir in install_reqs]

setup(name='funniest',
      version='0.1',
      description='The funniest joke in the world',
      url='http://github.com/storborg/funniest',
      author='Flying Circus',
      author_email='flyingcircus@example.com',
      license='MIT',
      packages=['funniest'],
      zip_safe=False,
      install_requires=reqs)