diff --git a/compiler/rustc_codegen_ssa/src/mir/rvalue.rs b/compiler/rustc_codegen_ssa/src/mir/rvalue.rs
index ff555f4273cbb..95b108b1d334a 100644
--- a/compiler/rustc_codegen_ssa/src/mir/rvalue.rs
+++ b/compiler/rustc_codegen_ssa/src/mir/rvalue.rs
@@ -364,6 +364,13 @@ impl<'a, 'tcx, Bx: BuilderMethods<'a, 'tcx>> FunctionCx<'a, 'tcx, Bx> {
     ) -> Bx::Value {
         assert_eq!(from_scalar.size(self.cx), to_scalar.size(self.cx));
 
+        // While optimizations will remove no-op transmutes, they might still be
+        // there in debug or things that aren't no-op in MIR because they change
+        // the Rust type but not the underlying layout/niche.
+        if from_scalar == to_scalar && from_backend_ty == to_backend_ty {
+            return imm;
+        }
+
         use abi::Primitive::*;
         imm = bx.from_immediate(imm);
 
diff --git a/tests/codegen/intrinsics/transmute.rs b/tests/codegen/intrinsics/transmute.rs
index ff297b2706578..4849b88c09c2e 100644
--- a/tests/codegen/intrinsics/transmute.rs
+++ b/tests/codegen/intrinsics/transmute.rs
@@ -10,6 +10,7 @@
 use std::intrinsics::mir::*;
 use std::intrinsics::{transmute, transmute_unchecked};
 use std::mem::MaybeUninit;
+use std::num::NonZero;
 
 // FIXME(LLVM18REMOVED): `trunc nuw` doesn't exist in LLVM 18, so once we no
 // longer support it the optional flag checks can be changed to required.
@@ -470,3 +471,27 @@ pub unsafe fn check_from_overalign(x: HighAlignScalar) -> u64 {
     // CHECK: ret i64 %[[VAL]]
     transmute(x)
 }
+
+#[repr(transparent)]
+struct Level1(std::num::NonZero<u32>);
+#[repr(transparent)]
+struct Level2(Level1);
+#[repr(transparent)]
+struct Level3(Level2);
+
+// CHECK-LABEL: @repeatedly_transparent_transmute
+// CHECK-SAME: (i32{{.+}}%[[ARG:[^)]+]])
+#[no_mangle]
+#[custom_mir(dialect = "runtime", phase = "optimized")]
+pub unsafe fn repeatedly_transparent_transmute(x: NonZero<u32>) -> Level3 {
+    // CHECK: start
+    // CHECK-NEXT: ret i32 %[[ARG]]
+    mir! {
+        {
+            let A = CastTransmute::<NonZero<u32>, Level1>(x);
+            let B = CastTransmute::<Level1, Level2>(A);
+            RET = CastTransmute::<Level2, Level3>(B);
+            Return()
+        }
+    }
+}