diff --git a/pkg/dev/podmandev/reconcile.go b/pkg/dev/podmandev/reconcile.go
index 0d6511d0b7b..779b6a8b111 100644
--- a/pkg/dev/podmandev/reconcile.go
+++ b/pkg/dev/podmandev/reconcile.go
@@ -2,6 +2,7 @@ package podmandev
 
 import (
 	"context"
+	"errors"
 	"fmt"
 	"io"
 	"path/filepath"
@@ -18,6 +19,7 @@ import (
 	"github.com/redhat-developer/odo/pkg/libdevfile"
 	"github.com/redhat-developer/odo/pkg/log"
 	odocontext "github.com/redhat-developer/odo/pkg/odo/context"
+	"github.com/redhat-developer/odo/pkg/port"
 	"github.com/redhat-developer/odo/pkg/watch"
 
 	corev1 "k8s.io/api/core/v1"
@@ -113,6 +115,29 @@ func (o *DevClient) reconcile(
 		componentStatus.RunExecuted = true
 	}
 
+	// By default, Podman will not forward to container applications listening on the loopback interface.
+	// So we are trying to detect such cases accordingly.
+	// See https://github.com/redhat-developer/odo/issues/6510#issuecomment-1439986558
+	loopbackPorts, err := port.DetectRemotePortsBoundOnLoopback(o.execClient, pod.Name, pod.Spec.Containers[0].Name, fwPorts)
+	if err != nil {
+		return fmt.Errorf("unable to detect container ports bound on the loopback interface: %w", err)
+	}
+	klog.V(4).Infof("detected %d ports bound on the loopback interface in the pod: %v", len(loopbackPorts), loopbackPorts)
+
+	if len(loopbackPorts) != 0 {
+		list := make([]string, 0, len(loopbackPorts))
+		for _, p := range loopbackPorts {
+			list = append(list, fmt.Sprintf("%s (%d)", p.PortName, p.ContainerPort))
+		}
+
+		log.Errorf(`Detected that the following port(s) can be reached only via the container loopback interface: %s.
+Port forwarding on Podman currently does not work with applications listening on the loopback interface.
+Either change the application to make those port(s) reachable on all interfaces (0.0.0.0), or rerun 'odo dev' with any of the following options:
+- --ignore-localhost: no error will be returned by odo, but port-forwarding on those ports might not work on Podman.
+- --forward-localhost: odo will inject a dedicated side container to redirect traffic to such ports.`, strings.Join(list, ", "))
+		return errors.New("cannot make port forwarding work with ports bound to the loopback interface only")
+	}
+
 	for _, fwPort := range fwPorts {
 		s := fmt.Sprintf("Forwarding from %s:%d -> %d", fwPort.LocalAddress, fwPort.LocalPort, fwPort.ContainerPort)
 		fmt.Fprintf(out, " -  %s", log.SboldColor(color.FgGreen, s))