diff --git a/.changeset/pretty-moose-flow.md b/.changeset/pretty-moose-flow.md
new file mode 100644
index 00000000000..ea68673d50e
--- /dev/null
+++ b/.changeset/pretty-moose-flow.md
@@ -0,0 +1,5 @@
+---
+"@remix-run/dev": patch
+---
+
+Polyfill Node `process` and `Buffer` globals when detected
diff --git a/packages/remix-dev/compiler/js/compiler.ts b/packages/remix-dev/compiler/js/compiler.ts
index b8c7b265752..7679e636873 100644
--- a/packages/remix-dev/compiler/js/compiler.ts
+++ b/packages/remix-dev/compiler/js/compiler.ts
@@ -1,7 +1,6 @@
 import * as path from "path";
 import { builtinModules as nodeBuiltins } from "module";
 import * as esbuild from "esbuild";
-import { nodeModulesPolyfillPlugin } from "esbuild-plugins-node-modules-polyfill";
 
 import type { RemixConfig } from "../../config";
 import { type Manifest } from "../../manifest";
@@ -12,6 +11,7 @@ import { cssFilePlugin } from "../plugins/cssImports";
 import { absoluteCssUrlsPlugin } from "../plugins/absoluteCssUrlsPlugin";
 import { deprecatedRemixPackagePlugin } from "../plugins/deprecatedRemixPackage";
 import { emptyModulesPlugin } from "../plugins/emptyModules";
+import { nodePolyfillsPlugin } from "../plugins/nodePolyfillsPlugin";
 import { mdxPlugin } from "../plugins/mdx";
 import { externalPlugin } from "../plugins/external";
 import { cssBundlePlugin } from "../plugins/cssBundlePlugin";
@@ -104,7 +104,7 @@ const createEsbuildConfig = (
     emptyModulesPlugin(ctx, /^@remix-run\/(deno|cloudflare|node)(\/.*)?$/, {
       includeNodeModules: true,
     }),
-    nodeModulesPolyfillPlugin(),
+    nodePolyfillsPlugin(),
     externalPlugin(/^node:.*/, { sideEffects: false }),
   ];
 
diff --git a/packages/remix-dev/compiler/plugins/nodePolyfillsPlugin.ts b/packages/remix-dev/compiler/plugins/nodePolyfillsPlugin.ts
new file mode 100644
index 00000000000..c9557a9e835
--- /dev/null
+++ b/packages/remix-dev/compiler/plugins/nodePolyfillsPlugin.ts
@@ -0,0 +1,11 @@
+import type { Plugin } from "esbuild";
+import { nodeModulesPolyfillPlugin } from "esbuild-plugins-node-modules-polyfill";
+
+export function nodePolyfillsPlugin(): Plugin {
+  return nodeModulesPolyfillPlugin({
+    globals: {
+      Buffer: true,
+      process: true,
+    },
+  });
+}
diff --git a/packages/remix-dev/compiler/server/compiler.ts b/packages/remix-dev/compiler/server/compiler.ts
index 4fb76bdad2d..f1fb0c0d491 100644
--- a/packages/remix-dev/compiler/server/compiler.ts
+++ b/packages/remix-dev/compiler/server/compiler.ts
@@ -1,5 +1,4 @@
 import * as esbuild from "esbuild";
-import { nodeModulesPolyfillPlugin } from "esbuild-plugins-node-modules-polyfill";
 
 import { type Manifest } from "../../manifest";
 import { loaders } from "../utils/loaders";
@@ -10,6 +9,7 @@ import { cssFilePlugin } from "../plugins/cssImports";
 import { absoluteCssUrlsPlugin } from "../plugins/absoluteCssUrlsPlugin";
 import { deprecatedRemixPackagePlugin } from "../plugins/deprecatedRemixPackage";
 import { emptyModulesPlugin } from "../plugins/emptyModules";
+import { nodePolyfillsPlugin } from "../plugins/nodePolyfillsPlugin";
 import { mdxPlugin } from "../plugins/mdx";
 import { serverAssetsManifestPlugin } from "./plugins/manifest";
 import { serverBareModulesPlugin } from "./plugins/bareImports";
@@ -67,7 +67,7 @@ const createEsbuildConfig = (
   ];
 
   if (ctx.config.serverPlatform !== "node") {
-    plugins.unshift(nodeModulesPolyfillPlugin());
+    plugins.unshift(nodePolyfillsPlugin());
   }
 
   return {
diff --git a/packages/remix-dev/package.json b/packages/remix-dev/package.json
index c0948cdc021..6dc8166f5ab 100644
--- a/packages/remix-dev/package.json
+++ b/packages/remix-dev/package.json
@@ -36,7 +36,7 @@
     "chokidar": "^3.5.1",
     "dotenv": "^16.0.0",
     "esbuild": "0.17.6",
-    "esbuild-plugins-node-modules-polyfill": "^1.0.16",
+    "esbuild-plugins-node-modules-polyfill": "^1.1.0",
     "execa": "5.1.1",
     "exit-hook": "2.2.1",
     "express": "^4.17.1",
diff --git a/yarn.lock b/yarn.lock
index 728c688b74e..9d8a3b185f2 100644
--- a/yarn.lock
+++ b/yarn.lock
@@ -2688,7 +2688,7 @@
     estree-walker "^2.0.1"
     picomatch "^2.2.2"
 
-"@rollup/pluginutils@^5.0.1", "@rollup/pluginutils@^5.0.2":
+"@rollup/pluginutils@^5.0.1":
   version "5.0.2"
   resolved "https://registry.npmjs.org/@rollup/pluginutils/-/pluginutils-5.0.2.tgz#012b8f53c71e4f6f9cb317e311df1404f56e7a33"
   integrity sha512-pTd9rIsP92h+B6wWwFbW8RkZv4hiR/xKsqre4SIuAOaOEQRxi0lqLke9k2/7WegC85GgUs9pjmOjCUi3In4vwA==
@@ -6132,12 +6132,14 @@ esbuild-openbsd-64@0.14.47:
   resolved "https://registry.npmjs.org/esbuild-openbsd-64/-/esbuild-openbsd-64-0.14.47.tgz#309af806db561aa886c445344d1aacab850dbdc5"
   integrity sha512-QpgN8ofL7B9z8g5zZqJE+eFvD1LehRlxr25PBkjyyasakm4599iroUpaj96rdqRlO2ShuyqwJdr+oNqWwTUmQw==
 
-esbuild-plugins-node-modules-polyfill@^1.0.16:
-  version "1.0.16"
-  resolved "https://registry.npmjs.org/esbuild-plugins-node-modules-polyfill/-/esbuild-plugins-node-modules-polyfill-1.0.16.tgz#c904592749efcd185df0245f9f9386ee0b371f4f"
-  integrity sha512-l2kfXhuqez0HnmzDjUh1y4fwDjAP8f2nW3u145AGp8kz7tQkgVKUb4yWeKbMJvbsHcpyMzguCOkOJD/+6SGvZw==
+esbuild-plugins-node-modules-polyfill@^1.1.0:
+  version "1.1.0"
+  resolved "https://registry.npmjs.org/esbuild-plugins-node-modules-polyfill/-/esbuild-plugins-node-modules-polyfill-1.1.0.tgz#9b701b0bff618ce24ac262fd49aa49dd3da58197"
+  integrity sha512-pfJAbt00Luc9uuYtXGlaUrcTzf4h95Cr9Lfw+7smTFmZWtbwbrN5Hsf+La4lfD6OygHvZeefZFILOGK1ZnuyjA==
   dependencies:
-    modern-node-polyfills "^1.0.0"
+    "@jspm/core" "^2.0.1"
+    local-pkg "^0.4.3"
+    resolve.exports "^2.0.2"
 
 esbuild-register@^3.3.2:
   version "3.3.2"
@@ -10212,15 +10214,6 @@ mlly@^1.0.0, mlly@^1.1.0:
     pkg-types "^1.0.1"
     ufo "^1.0.1"
 
-modern-node-polyfills@^1.0.0:
-  version "1.0.0"
-  resolved "https://registry.npmjs.org/modern-node-polyfills/-/modern-node-polyfills-1.0.0.tgz#f0ac8eddb49dd18f51a9f6e72d2934392bbc9720"
-  integrity sha512-w1yb6ae5qSUJJ2u41krkUAxs+L7i9143Qam8EuXwDMeZHxl1JN8RfTSXG4S2bt0RHIRMeoWm/HCeO0pNIHmIYQ==
-  dependencies:
-    "@jspm/core" "^2.0.1"
-    "@rollup/pluginutils" "^5.0.2"
-    local-pkg "^0.4.3"
-
 morgan@^1.10.0:
   version "1.10.0"
   resolved "https://registry.npmjs.org/morgan/-/morgan-1.10.0.tgz"
@@ -11827,6 +11820,11 @@ resolve.exports@^1.1.0:
   resolved "https://registry.npmjs.org/resolve.exports/-/resolve.exports-1.1.0.tgz"
   integrity sha512-J1l+Zxxp4XK3LUDZ9m60LRJF/mAe4z6a4xyabPHk7pvK5t35dACV32iIjJDFeWZFfZlO29w6SZ67knR0tHzJtQ==
 
+resolve.exports@^2.0.2:
+  version "2.0.2"
+  resolved "https://registry.npmjs.org/resolve.exports/-/resolve.exports-2.0.2.tgz#f8c934b8e6a13f539e38b7098e2e36134f01e800"
+  integrity sha512-X2UW6Nw3n/aMgDVy+0rSqgHlv39WZAlZrXCdnbyEiKm17DSqHX4MmQMaST3FbeWR5FTuRcUwYAziZajji0Y7mg==
+
 resolve@^1.1.6, resolve@^1.10.0, resolve@^1.10.1, resolve@^1.14.2, resolve@^1.19.0, resolve@^1.20.0:
   version "1.22.0"
   resolved "https://registry.npmjs.org/resolve/-/resolve-1.22.0.tgz"