diff --git a/.changeset/global-fetch-instanceof.md b/.changeset/global-fetch-instanceof.md
new file mode 100644
index 00000000000..b9dff67555e
--- /dev/null
+++ b/.changeset/global-fetch-instanceof.md
@@ -0,0 +1,5 @@
+---
+"@remix-run/node": patch
+---
+
+ensures fetch() return is instanceof global Response by removing extended classes for NodeRequest and NodeResponse in favor of custom interface type cast.
diff --git a/contributors.yml b/contributors.yml
index 91a7e07bbdd..ae7de85f83d 100644
--- a/contributors.yml
+++ b/contributors.yml
@@ -230,6 +230,7 @@
 - jaydiablo
 - jca41
 - jdeniau
+- jeeyoungk
 - JeffBeltran
 - jenseng
 - jeremyjfleming
diff --git a/integration/fetch-globals-test.ts b/integration/fetch-globals-test.ts
new file mode 100644
index 00000000000..172602c8f3a
--- /dev/null
+++ b/integration/fetch-globals-test.ts
@@ -0,0 +1,39 @@
+import { test, expect } from "@playwright/test";
+
+import type { Fixture, AppFixture } from "./helpers/create-fixture";
+import { createAppFixture, createFixture, js } from "./helpers/create-fixture";
+
+let fixture: Fixture;
+let appFixture: AppFixture;
+
+test.beforeAll(async () => {
+  fixture = await createFixture({
+    files: {
+      "app/routes/_index.tsx": js`
+        import { json } from "@remix-run/node";
+        import { useLoaderData } from "@remix-run/react";
+        export async function loader() {
+          const resp = await fetch('https://reqres.in/api/users?page=2');
+          return (resp instanceof Response) ? 'is an instance of global Response' : 'is not an instance of global Response';
+        }
+        export default function Index() {
+          let data = useLoaderData();
+          return (
+            <div>
+              {data}
+            </div>
+          )
+        }
+      `,
+    },
+  });
+
+  appFixture = await createAppFixture(fixture);
+});
+
+test.afterAll(async () => appFixture.close());
+
+test("returned variable from fetch() should be instance of global Response", async () => {
+  let response = await fixture.requestDocument("/");
+  expect(await response.text()).toMatch("is an instance of global Response");
+});
diff --git a/packages/remix-node/__tests__/fetch-test.ts b/packages/remix-node/__tests__/fetch-test.ts
index 6f7c8480662..e8fac2dffc6 100644
--- a/packages/remix-node/__tests__/fetch-test.ts
+++ b/packages/remix-node/__tests__/fetch-test.ts
@@ -1,6 +1,10 @@
 import { ReadableStream } from "@remix-run/web-stream";
+import {
+  Request as WebRequest,
+  Response as WebResponse,
+} from "@remix-run/web-fetch";
 
-import { Request } from "../fetch";
+import { Request, Response } from "../fetch";
 
 let test = {
   source: [
@@ -111,6 +115,22 @@ describe("Request", () => {
     expect(file.size).toBe(1023);
 
     expect(cloned instanceof Request).toBeTruthy();
+    expect(cloned instanceof WebRequest).toBeTruthy();
+  });
+
+  it("instanceOf", async () => {
+    let nodeReq = new Request("http://example.com");
+    let webReq = new WebRequest("http://example.com");
+    let nodeRes = new Response("http://example.com");
+    let webRes = new WebResponse("http://example.com");
+    expect(nodeReq instanceof Request).toBeTruthy();
+    expect(nodeReq instanceof WebRequest).toBeTruthy();
+    expect(webReq instanceof Request).toBeTruthy();
+    expect(webReq instanceof WebRequest).toBeTruthy();
+    expect(nodeRes instanceof Response).toBeTruthy();
+    expect(nodeRes instanceof WebResponse).toBeTruthy();
+    expect(webRes instanceof Response).toBeTruthy();
+    expect(webRes instanceof WebResponse).toBeTruthy();
   });
 });
 
diff --git a/packages/remix-node/fetch.ts b/packages/remix-node/fetch.ts
index b4182a055e7..1047e998ab4 100644
--- a/packages/remix-node/fetch.ts
+++ b/packages/remix-node/fetch.ts
@@ -9,6 +9,7 @@ export { FormData } from "@remix-run/web-fetch";
 export { File, Blob } from "@remix-run/web-file";
 
 type NodeHeadersInit = ConstructorParameters<typeof WebHeaders>[0];
+type NodeResponseInfo = ConstructorParameters<typeof WebResponse>[0];
 type NodeResponseInit = NonNullable<
   ConstructorParameters<typeof WebResponse>[1]
 >;
@@ -31,30 +32,27 @@ export type {
   NodeResponseInit as ResponseInit,
 };
 
-class NodeRequest extends WebRequest {
-  constructor(info: NodeRequestInfo, init?: NodeRequestInit) {
-    super(info, init as RequestInit);
-  }
+interface NodeRequest extends WebRequest {
+  get headers(): WebHeaders;
 
-  public get headers(): WebHeaders {
-    return super.headers as WebHeaders;
-  }
-
-  public clone(): NodeRequest {
-    return new NodeRequest(this);
-  }
+  clone(): NodeRequest;
 }
 
-class NodeResponse extends WebResponse {
-  public get headers(): WebHeaders {
-    return super.headers as WebHeaders;
-  }
+interface NodeResponse extends WebResponse {
+  get headers(): WebHeaders;
 
-  public clone(): NodeResponse {
-    return super.clone() as NodeResponse;
-  }
+  clone(): NodeResponse;
 }
 
+const NodeRequest = WebRequest as new (
+  info: NodeRequestInfo,
+  init?: NodeRequestInit
+) => NodeRequest;
+const NodeResponse = WebResponse as unknown as new (
+  info: NodeResponseInfo,
+  init?: NodeResponseInit
+) => NodeResponse;
+
 export {
   WebHeaders as Headers,
   NodeRequest as Request,