diff --git a/cibuildwheel/resources/constraints-python27.txt b/cibuildwheel/resources/constraints-python27.txt
index d76e06e33..2c95e8632 100644
--- a/cibuildwheel/resources/constraints-python27.txt
+++ b/cibuildwheel/resources/constraints-python27.txt
@@ -37,7 +37,7 @@ six==1.15.0
     #   virtualenv
 typing==3.7.4.3
     # via importlib-resources
-virtualenv==20.4.0
+virtualenv==20.4.2
     # via -r cibuildwheel/resources/constraints.in
 wheel==0.36.2
     # via
diff --git a/cibuildwheel/resources/constraints-python35.txt b/cibuildwheel/resources/constraints-python35.txt
index ab8fb3867..f71a1f1cd 100644
--- a/cibuildwheel/resources/constraints-python35.txt
+++ b/cibuildwheel/resources/constraints-python35.txt
@@ -18,7 +18,7 @@ importlib-resources==3.2.1
     # via virtualenv
 six==1.15.0
     # via virtualenv
-virtualenv==20.4.0
+virtualenv==20.4.2
     # via -r cibuildwheel/resources/constraints.in
 wheel==0.36.2
     # via
diff --git a/cibuildwheel/resources/constraints-python36.txt b/cibuildwheel/resources/constraints-python36.txt
index 5eb84f6d8..4e627a05b 100644
--- a/cibuildwheel/resources/constraints-python36.txt
+++ b/cibuildwheel/resources/constraints-python36.txt
@@ -20,7 +20,7 @@ six==1.15.0
     # via virtualenv
 typing-extensions==3.7.4.3
     # via importlib-metadata
-virtualenv==20.4.0
+virtualenv==20.4.2
     # via -r cibuildwheel/resources/constraints.in
 wheel==0.36.2
     # via
@@ -34,5 +34,5 @@ zipp==3.4.0
 # The following packages are considered to be unsafe in a requirements file:
 pip==21.0.1
     # via -r cibuildwheel/resources/constraints.in
-setuptools==52.0.0
+setuptools==53.0.0
     # via -r cibuildwheel/resources/constraints.in
diff --git a/cibuildwheel/resources/constraints-python37.txt b/cibuildwheel/resources/constraints-python37.txt
index d781bf603..f883f8529 100644
--- a/cibuildwheel/resources/constraints-python37.txt
+++ b/cibuildwheel/resources/constraints-python37.txt
@@ -18,7 +18,7 @@ six==1.15.0
     # via virtualenv
 typing-extensions==3.7.4.3
     # via importlib-metadata
-virtualenv==20.4.0
+virtualenv==20.4.2
     # via -r cibuildwheel/resources/constraints.in
 wheel==0.36.2
     # via
@@ -30,5 +30,5 @@ zipp==3.4.0
 # The following packages are considered to be unsafe in a requirements file:
 pip==21.0.1
     # via -r cibuildwheel/resources/constraints.in
-setuptools==52.0.0
+setuptools==53.0.0
     # via -r cibuildwheel/resources/constraints.in
diff --git a/cibuildwheel/resources/constraints-python38.txt b/cibuildwheel/resources/constraints-python38.txt
index 4fa010125..ed2868c91 100644
--- a/cibuildwheel/resources/constraints-python38.txt
+++ b/cibuildwheel/resources/constraints-python38.txt
@@ -14,7 +14,7 @@ filelock==3.0.12
     # via virtualenv
 six==1.15.0
     # via virtualenv
-virtualenv==20.4.0
+virtualenv==20.4.2
     # via -r cibuildwheel/resources/constraints.in
 wheel==0.36.2
     # via
@@ -24,5 +24,5 @@ wheel==0.36.2
 # The following packages are considered to be unsafe in a requirements file:
 pip==21.0.1
     # via -r cibuildwheel/resources/constraints.in
-setuptools==52.0.0
+setuptools==53.0.0
     # via -r cibuildwheel/resources/constraints.in
diff --git a/cibuildwheel/resources/constraints-python39.txt b/cibuildwheel/resources/constraints-python39.txt
index 4fa010125..ed2868c91 100644
--- a/cibuildwheel/resources/constraints-python39.txt
+++ b/cibuildwheel/resources/constraints-python39.txt
@@ -14,7 +14,7 @@ filelock==3.0.12
     # via virtualenv
 six==1.15.0
     # via virtualenv
-virtualenv==20.4.0
+virtualenv==20.4.2
     # via -r cibuildwheel/resources/constraints.in
 wheel==0.36.2
     # via
@@ -24,5 +24,5 @@ wheel==0.36.2
 # The following packages are considered to be unsafe in a requirements file:
 pip==21.0.1
     # via -r cibuildwheel/resources/constraints.in
-setuptools==52.0.0
+setuptools==53.0.0
     # via -r cibuildwheel/resources/constraints.in
diff --git a/cibuildwheel/resources/constraints.txt b/cibuildwheel/resources/constraints.txt
index 4fa010125..ed2868c91 100644
--- a/cibuildwheel/resources/constraints.txt
+++ b/cibuildwheel/resources/constraints.txt
@@ -14,7 +14,7 @@ filelock==3.0.12
     # via virtualenv
 six==1.15.0
     # via virtualenv
-virtualenv==20.4.0
+virtualenv==20.4.2
     # via -r cibuildwheel/resources/constraints.in
 wheel==0.36.2
     # via
@@ -24,5 +24,5 @@ wheel==0.36.2
 # The following packages are considered to be unsafe in a requirements file:
 pip==21.0.1
     # via -r cibuildwheel/resources/constraints.in
-setuptools==52.0.0
+setuptools==53.0.0
     # via -r cibuildwheel/resources/constraints.in