diff --git a/src/system/SystemPacketBuffer.cpp b/src/system/SystemPacketBuffer.cpp
index 0727a5cf3a923f..2831344c63f437 100644
--- a/src/system/SystemPacketBuffer.cpp
+++ b/src/system/SystemPacketBuffer.cpp
@@ -98,7 +98,9 @@ PacketBuffer * PacketBuffer::BuildFreeList()
         lHead          = lCursor;
     }
 
+#if !CHIP_SYSTEM_CONFIG_NO_LOCKING
     Mutex::Init(sBufferPoolMutex);
+#endif
 
     return static_cast<PacketBuffer *>(lHead);
 }