Skip to content
New issue

Have a question about this project? Sign up for a free GitHub account to open an issue and contact its maintainers and the community.

Sign up for GitHub

By clicking “Sign up for GitHub”, you agree to our terms of service and privacy statement. We’ll occasionally send you account related emails.

Already on GitHub? Sign in to your account

Jump to bottom

Ability to dock dimers. #118

Open
primaryodors opened this issue Aug 9, 2022 · 3 comments
Open

Ability to dock dimers. #118

primaryodors opened this issue Aug 9, 2022 · 3 comments
Labels
low priority Not a show stopper, but should be addressed.

Comments

@primaryodors
Copy link
Owner

If you make a spoonerism of PrimaryDock, it sounds like "dimer-y proc". Therefore, by its name, this application must be enhanced to allow docking ligands into dimers, ideally both heterodimers and homodimers.

Make it happen.
@primaryodors primaryodors added the CRITICAL Something is very wrong. label Aug 9, 2022
@primaryodors primaryodors added medium priority This should be made working as soon as time permits. and removed CRITICAL Something is very wrong. labels Aug 18, 2022
@electronicsbyjulie
Copy link
Contributor

The system of ligand + receptor could itself be considered a heterodimer. Therefore, the program already lives up to its name.

@electronicsbyjulie electronicsbyjulie added wontfix This will not be worked on. and removed medium priority This should be made working as soon as time permits. labels Nov 3, 2022
@primaryodors primaryodors added medium priority This should be made working as soon as time permits. and removed wontfix This will not be worked on. labels Nov 3, 2022
@primaryodors
Copy link
Owner Author

Nice try. 😛

@electronicsbyjulie electronicsbyjulie linked a pull request Jun 22, 2023 that will close this issue
G-protein based reshaping #268
Merged
@primaryodors primaryodors removed a link to a pull request Jun 22, 2023
G-protein based reshaping #268
Merged
@primaryodors
Copy link
Owner Author

This ticket isn't just about docking two proteins together, but docking a ligand inside a protein dimer. One example would be the ability to dock sugars and sweeteners in a TAS1R2+TAS1R3 dimer, and savory/umami compounds in a TAS1R1+TAS1R3 dimer. So #268 doesn't fulfill the purpose of this issue.

@primaryodors primaryodors added low priority Not a show stopper, but should be addressed. and removed medium priority This should be made working as soon as time permits. labels Jul 29, 2023
Sign up for free to join this conversation on GitHub. Already have an account? Sign in to comment
Assignees
No one assigned
Labels
low priority Not a show stopper, but should be addressed.
Projects
None yet
Milestone
No milestone
Development

No branches or pull requests
2 participants
@electronicsbyjulie @primaryodors