diff --git a/content/04.from-single-genes-to-gene-networks.md b/content/04.from-single-genes-to-gene-networks.md index 3a26b21..81b9b73 100644 --- a/content/04.from-single-genes-to-gene-networks.md +++ b/content/04.from-single-genes-to-gene-networks.md @@ -48,7 +48,7 @@ The model suggests that most genetic effects arise from these peripheral genes, [@doi:10.1016/j.cell.2018.05.051]. Trans effects occur when a genetic variant at one locus affects the expression of genes at distant loci, often on different chromosomes. This contrasts with cis effects, where variants influence genes in their immediate vicinity. -In this context, understanding *trans* effects is crucial for grasping the indirect influence of peripheral genes on core traits [@doi:10.20900/jpbs.20170014(S1-S8)]. +In this context, understanding *trans* effects is crucial for grasping the indirect influence of peripheral genes on core traits [@doi:10.20900/jpbs.20170014S2]. However, the study of trans effects has inherent challenges. One of the primary limitations is their typically small effect sizes, which makes their detection difficult compared to cis effects.