diff --git a/store/tikv/backoff.go b/store/tikv/backoff.go
index b9e70af36094e..84a4478fa0837 100644
--- a/store/tikv/backoff.go
+++ b/store/tikv/backoff.go
@@ -17,6 +17,7 @@ import (
 	"fmt"
 	"math"
 	"math/rand"
+	"strings"
 	"time"
 
 	"github.com/juju/errors"
@@ -201,6 +202,9 @@ func (b *Backoffer) WithVars(vars *kv.Variables) *Backoffer {
 // Backoff sleeps a while base on the backoffType and records the error message.
 // It returns a retryable error if total sleep time exceeds maxSleep.
 func (b *Backoffer) Backoff(typ backoffType, err error) error {
+	if strings.Contains(err.Error(), mismatchClusterID) {
+		log.Fatalf("critical error %v", err)
+	}
 	select {
 	case <-b.ctx.Done():
 		return errors.Trace(err)
diff --git a/store/tikv/error.go b/store/tikv/error.go
index 54c48bfa2971e..467d346d146fc 100644
--- a/store/tikv/error.go
+++ b/store/tikv/error.go
@@ -24,6 +24,9 @@ var (
 	ErrBodyMissing = errors.New("response body is missing")
 )
 
+// mismatchClusterID represents the message that the cluster ID of the PD client does not match the PD.
+const mismatchClusterID = "mismatch cluster id"
+
 // TiDB decides whether to retry transaction by checking if error message contains
 // string "try again later" literally.
 // In TiClient we use `errors.Annotate(err, txnRetryableMark)` to direct TiDB to