diff --git a/pandas/conftest.py b/pandas/conftest.py
index 07a20d9e0eb5c..688ad6dcc5e48 100644
--- a/pandas/conftest.py
+++ b/pandas/conftest.py
@@ -326,6 +326,7 @@ def frame_or_series(request):
     return request.param
 
 
+# error: List item 0 has incompatible type "Type[Index]"; expected "Type[IndexOpsMixin]"
 @pytest.fixture(
     params=[pd.Index, pd.Series], ids=["index", "series"]  # type: ignore[list-item]
 )
diff --git a/pandas/core/arrays/boolean.py b/pandas/core/arrays/boolean.py
index 260cd08707473..b37cf0a0ec579 100644
--- a/pandas/core/arrays/boolean.py
+++ b/pandas/core/arrays/boolean.py
@@ -76,7 +76,8 @@ class BooleanDtype(BaseMaskedDtype):
 
     name = "boolean"
 
-    # mypy: https://github.com/python/mypy/issues/4125
+    # https://github.com/python/mypy/issues/4125
+    # error: Signature of "type" incompatible with supertype "BaseMaskedDtype"
     @property
     def type(self) -> Type:  # type: ignore[override]
         return np.bool_
diff --git a/pandas/core/arrays/floating.py b/pandas/core/arrays/floating.py
index a43b30f5043e2..aace5583ff47a 100644
--- a/pandas/core/arrays/floating.py
+++ b/pandas/core/arrays/floating.py
@@ -78,7 +78,10 @@ def _get_common_dtype(self, dtypes: List[DtypeObj]) -> Optional[DtypeObj]:
         if not all(isinstance(t, FloatingDtype) for t in dtypes):
             return None
         np_dtype = np.find_common_type(
-            [t.numpy_dtype for t in dtypes], []  # type: ignore[union-attr]
+            # error: Item "ExtensionDtype" of "Union[Any, ExtensionDtype]" has no
+            # attribute "numpy_dtype"
+            [t.numpy_dtype for t in dtypes],  # type: ignore[union-attr]
+            [],
         )
         if np.issubdtype(np_dtype, np.floating):
             return FLOAT_STR_TO_DTYPE[str(np_dtype)]
diff --git a/pandas/core/common.py b/pandas/core/common.py
index 871f5ac651cce..0b2dec371bf02 100644
--- a/pandas/core/common.py
+++ b/pandas/core/common.py
@@ -493,7 +493,12 @@ def convert_to_list_like(
     inputs are returned unmodified whereas others are converted to list.
     """
     if isinstance(values, (list, np.ndarray, ABCIndex, ABCSeries, ABCExtensionArray)):
-        # np.ndarray resolving as Any gives a false positive
+        # error: Incompatible return value type (got "Union[Any, List[Any], Index,
+        # Series, ExtensionArray]", expected "Union[List[Any], ExtensionArray]")
+        # error: Incompatible return value type (got "Union[Any, List[Any], Index,
+        # Series, ExtensionArray]", expected "Union[List[Any], Index]")
+        # error: Incompatible return value type (got "Union[Any, List[Any], Index,
+        # Series, ExtensionArray]", expected "Union[List[Any], Series]")
         return values  # type: ignore[return-value]
     elif isinstance(values, abc.Iterable) and not isinstance(values, str):
         return list(values)
diff --git a/pandas/core/frame.py b/pandas/core/frame.py
index 911d6fbfadd5d..38cd730efabd1 100644
--- a/pandas/core/frame.py
+++ b/pandas/core/frame.py
@@ -4079,7 +4079,13 @@ def extract_unique_dtypes_from_dtypes_set(
                 for unique_dtype in unique_dtypes
                 if (
                     issubclass(
-                        unique_dtype.type, tuple(dtypes_set)  # type: ignore[arg-type]
+                        # error: Argument 1 to "tuple" has incompatible type
+                        # "FrozenSet[Union[ExtensionDtype, Union[str, Any], Type[str],
+                        # Type[float], Type[int], Type[complex], Type[bool],
+                        # Type[object]]]"; expected "Iterable[Union[type, Tuple[Any,
+                        # ...]]]"
+                        unique_dtype.type,
+                        tuple(dtypes_set),  # type: ignore[arg-type]
                     )
                     or (
                         np.number in dtypes_set
@@ -6382,7 +6388,14 @@ def _dispatch_frame_op(self, right, func, axis: Optional[int] = None):
 
             # TODO operate_blockwise expects a manager of the same type
             bm = self._mgr.operate_blockwise(
-                right._mgr, array_op  # type: ignore[arg-type]
+                # error: Argument 1 to "operate_blockwise" of "ArrayManager" has
+                # incompatible type "Union[ArrayManager, BlockManager]"; expected
+                # "ArrayManager"
+                # error: Argument 1 to "operate_blockwise" of "BlockManager" has
+                # incompatible type "Union[ArrayManager, BlockManager]"; expected
+                # "BlockManager"
+                right._mgr,  # type: ignore[arg-type]
+                array_op,
             )
             return type(self)(bm)
 
diff --git a/pandas/core/generic.py b/pandas/core/generic.py
index e103f0e938a76..327a69e7f3fb4 100644
--- a/pandas/core/generic.py
+++ b/pandas/core/generic.py
@@ -752,7 +752,12 @@ def swapaxes(self: FrameOrSeries, axis1, axis2, copy=True) -> FrameOrSeries:
         # ignore needed because of NDFrame constructor is different than
         # DataFrame/Series constructors.
         return self._constructor(
-            new_values, *new_axes  # type: ignore[arg-type]
+            # error: Argument 2 to "NDFrame" has incompatible type "*Generator[Index,
+            # None, None]"; expected "bool" [arg-type]
+            # error: Argument 2 to "NDFrame" has incompatible type "*Generator[Index,
+            # None, None]"; expected "Optional[Mapping[Optional[Hashable], Any]]"
+            new_values,
+            *new_axes,  # type: ignore[arg-type]
         ).__finalize__(self, method="swapaxes")
 
     @final
@@ -11046,37 +11051,47 @@ def _inplace_method(self, other, op):
         return self
 
     def __iadd__(self, other):
+        # error: Unsupported left operand type for + ("Type[NDFrame]")
         return self._inplace_method(other, type(self).__add__)  # type: ignore[operator]
 
     def __isub__(self, other):
+        # error: Unsupported left operand type for - ("Type[NDFrame]")
         return self._inplace_method(other, type(self).__sub__)  # type: ignore[operator]
 
     def __imul__(self, other):
+        # error: Unsupported left operand type for * ("Type[NDFrame]")
         return self._inplace_method(other, type(self).__mul__)  # type: ignore[operator]
 
     def __itruediv__(self, other):
+        # error: Unsupported left operand type for / ("Type[NDFrame]")
         return self._inplace_method(
             other, type(self).__truediv__  # type: ignore[operator]
         )
 
     def __ifloordiv__(self, other):
+        # error: Unsupported left operand type for // ("Type[NDFrame]")
         return self._inplace_method(
             other, type(self).__floordiv__  # type: ignore[operator]
         )
 
     def __imod__(self, other):
+        # error: Unsupported left operand type for % ("Type[NDFrame]")
         return self._inplace_method(other, type(self).__mod__)  # type: ignore[operator]
 
     def __ipow__(self, other):
+        # error: Unsupported left operand type for ** ("Type[NDFrame]")
         return self._inplace_method(other, type(self).__pow__)  # type: ignore[operator]
 
     def __iand__(self, other):
+        # error: Unsupported left operand type for & ("Type[NDFrame]")
         return self._inplace_method(other, type(self).__and__)  # type: ignore[operator]
 
     def __ior__(self, other):
+        # error: Unsupported left operand type for | ("Type[NDFrame]")
         return self._inplace_method(other, type(self).__or__)  # type: ignore[operator]
 
     def __ixor__(self, other):
+        # error: Unsupported left operand type for ^ ("Type[NDFrame]")
         return self._inplace_method(other, type(self).__xor__)  # type: ignore[operator]
 
     # ----------------------------------------------------------------------
diff --git a/pandas/core/internals/array_manager.py b/pandas/core/internals/array_manager.py
index 905fa448ff033..97a2d4037bf26 100644
--- a/pandas/core/internals/array_manager.py
+++ b/pandas/core/internals/array_manager.py
@@ -148,6 +148,7 @@ def items(self) -> Index:
         return self._axes[-1]
 
     @property
+    # error: Signature of "axes" incompatible with supertype "DataManager"
     def axes(self) -> List[Index]:  # type: ignore[override]
         # mypy doesn't work to override attribute with property
         # see https://github.com/python/mypy/issues/4125
@@ -454,11 +455,19 @@ def apply_with_block(self: T, f, align_keys=None, swap_axis=True, **kwargs) -> T
                         if obj.ndim == 2:
                             kwargs[k] = obj[[i]]
 
+            # error: Item "ExtensionArray" of "Union[Any, ExtensionArray]" has no
+            # attribute "tz"
             if hasattr(arr, "tz") and arr.tz is None:  # type: ignore[union-attr]
                 # DatetimeArray needs to be converted to ndarray for DatetimeBlock
+
+                # error: Item "ExtensionArray" of "Union[Any, ExtensionArray]" has no
+                # attribute "_data"
                 arr = arr._data  # type: ignore[union-attr]
             elif arr.dtype.kind == "m" and not isinstance(arr, np.ndarray):
                 # TimedeltaArray needs to be converted to ndarray for TimedeltaBlock
+
+                # error: Item "ExtensionArray" of "Union[Any, ExtensionArray]" has no
+                # attribute "_data"
                 arr = arr._data  # type: ignore[union-attr]
 
             if self.ndim == 2:
diff --git a/pandas/core/nanops.py b/pandas/core/nanops.py
index 247d068aaca8f..d5d04ea2b1539 100644
--- a/pandas/core/nanops.py
+++ b/pandas/core/nanops.py
@@ -1748,6 +1748,7 @@ def na_accum_func(values: ArrayLike, accum_func, *, skipna: bool) -> ArrayLike:
             # TODO: have this case go through a DTA method?
             # For DatetimeTZDtype, view result as M8[ns]
             npdtype = orig_dtype if isinstance(orig_dtype, np.dtype) else "M8[ns]"
+            # error: "Type[ExtensionArray]" has no attribute "_simple_new"
             result = type(values)._simple_new(  # type: ignore[attr-defined]
                 result.view(npdtype), dtype=orig_dtype
             )
diff --git a/pandas/core/series.py b/pandas/core/series.py
index e1a6c6884e003..25b46d2cbd278 100644
--- a/pandas/core/series.py
+++ b/pandas/core/series.py
@@ -1094,6 +1094,9 @@ def _set_labels(self, key, value):
     def _set_values(self, key, value):
         if isinstance(key, Series):
             key = key._values
+        # error: Incompatible types in assignment (expression has type "Union[Any,
+        # BlockManager]", variable has type "Union[SingleArrayManager,
+        # SingleBlockManager]")
         self._mgr = self._mgr.setitem(  # type: ignore[assignment]
             indexer=key, value=value
         )
diff --git a/pandas/io/common.py b/pandas/io/common.py
index e5da12d7b1753..cf3b92ec93b1f 100644
--- a/pandas/io/common.py
+++ b/pandas/io/common.py
@@ -625,6 +625,9 @@ def get_handle(
                 )
             else:
                 handle = gzip.GzipFile(
+                    # error: Argument "fileobj" to "GzipFile" has incompatible type
+                    # "Union[str, Union[IO[Any], RawIOBase, BufferedIOBase, TextIOBase,
+                    # TextIOWrapper, mmap]]"; expected "Optional[IO[bytes]]"
                     fileobj=handle,  # type: ignore[arg-type]
                     mode=ioargs.mode,
                     **compression_args,
@@ -633,6 +636,10 @@ def get_handle(
         # BZ Compression
         elif compression == "bz2":
             handle = bz2.BZ2File(
+                # Argument 1 to "BZ2File" has incompatible type "Union[str,
+                # Union[IO[Any], RawIOBase, BufferedIOBase, TextIOBase, TextIOWrapper,
+                # mmap]]"; expected "Union[Union[str, bytes, _PathLike[str],
+                # _PathLike[bytes]], IO[bytes]]"
                 handle,  # type: ignore[arg-type]
                 mode=ioargs.mode,
                 **compression_args,
@@ -690,6 +697,9 @@ def get_handle(
     is_wrapped = False
     if is_text and (compression or _is_binary_mode(handle, ioargs.mode)):
         handle = TextIOWrapper(
+            # error: Argument 1 to "TextIOWrapper" has incompatible type
+            # "Union[IO[bytes], IO[Any], RawIOBase, BufferedIOBase, TextIOBase, mmap]";
+            # expected "IO[bytes]"
             handle,  # type: ignore[arg-type]
             encoding=ioargs.encoding,
             errors=errors,
@@ -752,6 +762,10 @@ def __init__(
         kwargs_zip: Dict[str, Any] = {"compression": zipfile.ZIP_DEFLATED}
         kwargs_zip.update(kwargs)
 
+        # error: Argument 1 to "__init__" of "ZipFile" has incompatible type
+        # "Union[_PathLike[str], Union[str, Union[IO[Any], RawIOBase, BufferedIOBase,
+        # TextIOBase, TextIOWrapper, mmap]]]"; expected "Union[Union[str,
+        # _PathLike[str]], IO[bytes]]"
         super().__init__(file, mode, **kwargs_zip)  # type: ignore[arg-type]
 
     def write(self, data):
@@ -849,6 +863,8 @@ def _maybe_memory_map(
         handles.append(handle)
 
     try:
+        # error: Argument 1 to "_MMapWrapper" has incompatible type "Union[IO[Any],
+        # RawIOBase, BufferedIOBase, TextIOBase, mmap]"; expected "IO[Any]"
         wrapped = cast(mmap.mmap, _MMapWrapper(handle))  # type: ignore[arg-type]
         handle.close()
         handles.remove(handle)
diff --git a/pandas/io/pickle.py b/pandas/io/pickle.py
index 785afce9e0214..6a91c12ee286e 100644
--- a/pandas/io/pickle.py
+++ b/pandas/io/pickle.py
@@ -104,12 +104,19 @@ def to_pickle(
             # "zip" would also be here if pandas.io.common._BytesZipFile
             # wouldn't buffer write calls
             handles.handle.write(
+                # error: Argument 1 to "write" of "TextIOBase" has incompatible type
+                # "bytes"; expected "str"
                 pickle.dumps(obj, protocol=protocol)  # type: ignore[arg-type]
             )
         else:
             # letting pickle write directly to the buffer is more memory-efficient
             pickle.dump(
-                obj, handles.handle, protocol=protocol  # type: ignore[arg-type]
+                # error: Argument 2 to "dump" has incompatible type "Union[IO[Any],
+                # RawIOBase, BufferedIOBase, TextIOBase, TextIOWrapper, mmap]"; expected
+                # "IO[bytes]"
+                obj,
+                handles.handle,  # type: ignore[arg-type]
+                protocol=protocol,
             )
 
 
@@ -204,6 +211,9 @@ def read_pickle(
                 with warnings.catch_warnings(record=True):
                     # We want to silence any warnings about, e.g. moved modules.
                     warnings.simplefilter("ignore", Warning)
+                    # error: Argument 1 to "load" has incompatible type "Union[IO[Any],
+                    # RawIOBase, BufferedIOBase, TextIOBase, TextIOWrapper, mmap]";
+                    # expected "IO[bytes]"
                     return pickle.load(handles.handle)  # type: ignore[arg-type]
             except excs_to_catch:
                 # e.g.
diff --git a/pandas/io/pytables.py b/pandas/io/pytables.py
index 25cabbb7c61b9..ceb4900b887f1 100644
--- a/pandas/io/pytables.py
+++ b/pandas/io/pytables.py
@@ -4022,10 +4022,14 @@ def get_blk_items(mgr):
             new_labels = Index(axis_labels).difference(Index(data_columns))
             mgr = frame.reindex(new_labels, axis=axis)._mgr
 
+            # error: Item "ArrayManager" of "Union[ArrayManager, BlockManager]" has no
+            # attribute "blocks"
             blocks = list(mgr.blocks)  # type: ignore[union-attr]
             blk_items = get_blk_items(mgr)
             for c in data_columns:
                 mgr = frame.reindex([c], axis=axis)._mgr
+                # error: Item "ArrayManager" of "Union[ArrayManager, BlockManager]" has
+                # no attribute "blocks"
                 blocks.extend(mgr.blocks)  # type: ignore[union-attr]
                 blk_items.extend(get_blk_items(mgr))
 
diff --git a/pandas/io/stata.py b/pandas/io/stata.py
index 462c7b41f4271..ebc0395aec0b2 100644
--- a/pandas/io/stata.py
+++ b/pandas/io/stata.py
@@ -1091,6 +1091,9 @@ def __init__(
             compression=compression,
         ) as handles:
             # Copy to BytesIO, and ensure no encoding
+
+            # Argument 1 to "BytesIO" has incompatible type "Union[Any, bytes, None,
+            # str]"; expected "bytes"
             self.path_or_buf = BytesIO(handles.handle.read())  # type: ignore[arg-type]
 
         self._read_header()