diff --git a/.github/workflows/ingest-to-phylogenetic.yaml b/.github/workflows/ingest-to-phylogenetic.yaml
new file mode 100644
index 0000000..87dc075
--- /dev/null
+++ b/.github/workflows/ingest-to-phylogenetic.yaml
@@ -0,0 +1,142 @@
+name: Ingest to phylogenetic
+
+defaults:
+  run:
+    # This is the same as GitHub Action's `bash` keyword as of 20 June 2023:
+    # https://docs.github.com/en/actions/using-workflows/workflow-syntax-for-github-actions#jobsjob_idstepsshell
+    #
+    # Completely spelling it out here so that GitHub can't change it out from under us
+    # and we don't have to refer to the docs to know the expected behavior.
+    shell: bash --noprofile --norc -eo pipefail {0}
+
+on:
+  schedule:
+    # Note times are in UTC, which is 1 or 2 hours behind CET depending on daylight savings.
+    #
+    # Note the actual runs might be late.
+    # Numerous people were confused, about that, including me:
+    #  - https://github.uint.cloudmunity/t/scheduled-action-running-consistently-late/138025/11
+    #  - https://github.com/github/docs/issues/3059
+    #
+    # Note, '*' is a special character in YAML, so you have to quote this string.
+    #
+    # Docs:
+    #  - https://docs.github.com/en/actions/learn-github-actions/events-that-trigger-workflows#schedule
+    #
+    # Tool that deciphers this particular format of crontab string:
+    #  - https://crontab.guru/
+    #
+    # Runs at 4pm UTC (12pm EDT) since curation by NCBI happens on the East Coast.
+    - cron: '0 16 * * *'
+  
+  workflow_dispatch:
+    inputs:
+      ingest_image:
+        description: 'Specific container image to use for ingest workflow (will override the default of "nextstrain build")'
+        required: false
+      phylogenetic_image:
+        description: 'Specific container image to use for phylogenetic workflow (will override the default of "nextstrain build")'
+        required: false
+
+jobs:
+  ingest:
+    permissions:
+      id-token: write
+    uses: nextstrain/.github/.github/workflows/pathogen-repo-build.yaml@master
+    secrets: inherit
+    with:
+      # Starting with the default docker runtime
+      # We can migrate to AWS Batch when/if we need to for more resources or if
+      # the job runs longer than the GH Action limit of 6 hours.
+      runtime: docker
+      env: |
+        NEXTSTRAIN_DOCKER_IMAGE: ${{ inputs.ingest_image }}
+      run: |
+        nextstrain build \
+          --env AWS_ACCESS_KEY_ID \
+          --env AWS_SECRET_ACCESS_KEY \
+          ingest \
+            upload_all \
+            --configfile build-configs/nextstrain-automation/config.yaml
+      # Specifying artifact name to differentiate ingest build outputs from
+      # the phylogenetic build outputs
+      artifact-name: ingest-build-output
+      artifact-paths: |
+        ingest/results/
+        ingest/benchmarks/
+        ingest/logs/
+        ingest/.snakemake/log/
+  
+  # Check if ingest results include new data by checking for the cache
+  # of the file with the results' Metadata.sh256sum (which should have been added within upload-to-s3)
+  # GitHub will remove any cache entries that have not been accessed in over 7 days,
+  # so if the workflow has not been run over 7 days then it will trigger phylogenetic.
+  check-new-data:
+    needs: [ingest]
+    runs-on: ubuntu-latest
+    outputs:
+      cache-hit: ${{ steps.check-cache.outputs.cache-hit }}
+    steps:
+      - name: Get sha256sum
+        id: get-sha256sum
+        env:
+          AWS_DEFAULT_REGION: ${{ vars.AWS_DEFAULT_REGION }}
+        run: |
+          s3_urls=(
+            "s3://nextstrain-data/files/workflows/measles/metadata.tsv.zst"
+            "s3://nextstrain-data/files/workflows/measles/sequences.fasta.zst"
+          )
+
+          # Code below is modified from ingest/upload-to-s3
+          # https://github.com/nextstrain/ingest/blob/c0b4c6bb5e6ccbba86374d2c09b42077768aac23/upload-to-s3#L23-L29
+          
+          
+          no_hash=0000000000000000000000000000000000000000000000000000000000000000
+
+          for s3_url in "${s3_urls[@]}"; do
+            s3path="${s3_url#s3://}"
+            bucket="${s3path%%/*}"
+            key="${s3path#*/}"
+
+            s3_hash="$(aws s3api head-object --no-sign-request --bucket "$bucket" --key "$key" --query Metadata.sha256sum --output text 2>/dev/null || echo "$no_hash")"
+            echo "${s3_hash}" | tee -a ingest-output-sha256sum
+          done
+
+      - name: Check cache
+        id: check-cache
+        uses: actions/cache@v4
+        with:
+          path: ingest-output-sha256sum
+          key: ingest-output-sha256sum-${{ hashFiles('ingest-output-sha256sum') }}
+          lookup-only: true
+  
+  phylogenetic:
+    needs: [check-new-data]
+    if: ${{ needs.check-new-data.outputs.cache-hit != 'true' }}
+    permissions:
+      id-token: write
+    uses: nextstrain/.github/.github/workflows/pathogen-repo-build.yaml@master
+    secrets: inherit
+    with:
+      # Starting with the default docker runtime
+      # We can migrate to AWS Batch when/if we need to for more resources or if
+      # the job runs longer than the GH Action limit of 6 hours.
+      runtime: docker
+      env: |
+        NEXTSTRAIN_DOCKER_IMAGE: ${{ inputs.phylogenetic_image }}
+      run: |
+        nextstrain build \
+          --env AWS_ACCESS_KEY_ID \
+          --env AWS_SECRET_ACCESS_KEY \
+          phylogenetic \
+            deploy_all \
+            --configfile build-configs/nextstrain-automation/config.yaml
+      # Specifying artifact name to differentiate ingest build outputs from
+      # the phylogenetic build outputs
+      artifact-name: phylogenetic-build-output
+      artifact-paths: |
+        phylogenetic/auspice/
+        phylogenetic/results/
+        phylogenetic/benchmarks/
+        phylogenetic/logs/
+        phylogenetic/.snakemake/log/
diff --git a/CHANGES.md b/CHANGES.md
index f65d6d8..4760a6c 100644
--- a/CHANGES.md
+++ b/CHANGES.md
@@ -1,6 +1,7 @@
 # CHANGELOG
-* 2 April 2024: Add nextstrain-automation build-configs for deploying the final Auspice dataset of the phylogenetic workflow
-* 1 April 2024: Create a tree using the 450 nucleotides encoding the carboxyl-terminal 150 amino acids of the nucleoprotein (N450), which is highly represented on NCBI for measles. [PR #20](https://github.com/nextstrain/measles/pull/20)
+* 10 April 2024: Add a single GH Action workflow to automate the ingest and phylogenetic workflows [PR #22](https://github.com/nextstrain/measles/pull/22)
+* 2 April 2024: Add nextstrain-automation build-configs for deploying the final Auspice dataset of the phylogenetic workflow [PR #21](https://github.com/nextstrain/measles/pull/21)
+* 1 April 2024: Create a "N450" tree using the 450 nucleotides encoding the carboxyl-terminal 150 amino acids of the nucleoprotein, which is highly represented on NCBI for measles. [PR #20](https://github.com/nextstrain/measles/pull/20)
 * 15 March 2024: Connect ingest and phylogenetic workflows to follow the pathogen-repo-guide by uploading ingest output to S3, downloading ingest output from S3 to phylogenetic directory, using "accession" column as the ID column, and using a color scheme that matches the new region name format. [PR #19](https://github.com/nextstrain/measles/pull/19)
 * 1 March 2024: Add phylogenetic directory to follow the pathogen-repo-guide, and update the CI workflow to match the new file structure. [PR #18](https://github.com/nextstrain/measles/pull/18)
 * 14 February 2024: Add ingest directory from pathogen-repo-guide and make measles-specific modifications. [PR #10](https://github.com/nextstrain/measles/pull/10)