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measles_reference.gb
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LOCUS NC_001498 15894 bp cRNA linear VRL 07-MAR-2013
DEFINITION Measles virus, complete genome.
ACCESSION NC_001498
VERSION NC_001498.1
DBLINK Project: 15025
BioProject: PRJNA15025
KEYWORDS RefSeq.
SOURCE Measles morbillivirus
ORGANISM Measles morbillivirus
Viruses; ssRNA viruses; ssRNA negative-strand viruses;
Mononegavirales; Paramyxoviridae; Morbillivirus.
REFERENCE 1 (sites)
AUTHORS Rima,B.K. and Duprex,W.P.
TITLE The measles virus replication cycle
JOURNAL Curr. Top. Microbiol. Immunol. 329, 77-102 (2009)
PUBMED 19198563
REFERENCE 2
AUTHORS Takeuchi,K., Miyajima,N., Kobune,F. and Tashiro,M.
TITLE Comparative nucleotide sequence analyses of the entire genomes of
B95a cell-isolated and vero cell-isolated measles viruses from the
same patient
JOURNAL Virus Genes 20 (3), 253-257 (2000)
PUBMED 10949953
REFERENCE 3 (bases 1807 to 2705)
AUTHORS Wardrop,E.A. and Briedis,D.J.
TITLE Characterization of V protein in measles virus-infected cells
JOURNAL J. Virol. 65 (7), 3421-3428 (1991)
PUBMED 2041073
REFERENCE 4 (bases 1748 to 3402)
AUTHORS Cattaneo,R., Kaelin,K., Baczko,K. and Billeter,M.A.
TITLE Measles virus editing provides an additional cysteine-rich protein
JOURNAL Cell 56 (5), 759-764 (1989)
PUBMED 2924348
REFERENCE 5 (bases 1748 to 3402)
AUTHORS Bellini,W.J., Englund,G., Richardson,C.D., Rozenblatt,S. and
Lazzarini,R.A.
TITLE Matrix genes of measles virus and canine distemper virus: cloning,
nucleotide sequences, and deduced amino acid sequences
JOURNAL J. Virol. 58 (2), 408-416 (1986)
PUBMED 3754588
REFERENCE 6 (bases 1748 to 3402)
AUTHORS Bellini,W.J., Englund,G., Rozenblatt,S., Arnheiter,H. and
Richardson,C.D.
TITLE Measles virus P gene codes for two proteins
JOURNAL J. Virol. 53 (3), 908-919 (1985)
PUBMED 3882996
REFERENCE 7 (bases 1 to 15894)
CONSRTM NCBI Genome Project
TITLE Direct Submission
JOURNAL Submitted (01-AUG-2000) National Center for Biotechnology
Information, NIH, Bethesda, MD 20894, USA
REFERENCE 8 (bases 1 to 15894)
AUTHORS Takeuchi,K., Tanabayashi,K. and Tashiro,M.
TITLE Direct Submission
JOURNAL Submitted (10-JUL-1998) Kaoru Takeuchi, National Institute of
Infectious Diseases, Viral Disease and Vaccine Contorol; 4-7-1
Gakuen, Musashi-murayama, Tokyo 208-0011, Japan
(E-mail:ktake@nih.go.jp, Tel:81-42-561-0771(ex.530),
Fax:81-42-567-5631)
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AB016162.
Sequence updated (21-Jul-1998)
Sequence updated (11-Dec-1998).
COMPLETENESS: full length.
FEATURES Location/Qualifiers
source 1..15894
/organism="Measles morbillivirus"
/mol_type="viral cRNA"
/strain="Ichinose-B95a"
/db_xref="taxon:11234"
CDS 108..1685
/gene="N"
/codon_start=1
/product="nucleocapsid protein"
/protein_id="NP_056918.1"
/db_xref="GeneID:1489804"
/translation="MATLLRSLALFKRNKDKPPITSGSGGAIRGIKHIIIVPIPGDSS
ITTRSRLLDRLVRLIGNPDVSGPKLTGALIGILSLFVESPGQLIQRITDDPDVSIRLL
EVVQSDQSQSGLTFASRGTNMEDEADQYFSHDDPSSSDQSRSGWFENKEISDIEVQDP
EGFNMILGTILAQIWVLLAKAVTAPDTAADSELRRWIKYTQQRRVVGEFRLERKWLDV
VRNRIAEDLSLRRFMVALILDIKRTPGNKPRIAEMICDIDTYIVEAGLASFILTIKFG
IETMYPALGLHEFAGELSTLESLMNLYQQMGETAPYMVILENSIQNKFSAGSYPLLWS
YAMGVGVELENSMGGLNFGRSYFDPAYFRLGQEMVRRSAGKVSSTLASELGITAEDAR
LVSEIAMHTTEDRISRAVGPRQAQVSFLHGDQSENELPGLGGKEDRRVKQGRGEARES
YRETGSSRASDARAAHPPTSMPLDIDTASESGQDPQDSRRSADALLRLQAMAGILEEQ
GSDTDTPRVYNDRDLLD"
CDS 1807..3330
/gene="P"
/gene_synonym="P"
/note="subunit of RNA dependent RNA polymerase (RdRp);
chaperone for Measles virus nucleocapsid protein"
/codon_start=1
/product="phosphoprotein"
/protein_id="NP_056919.1"
/db_xref="GeneID:1489805"
/translation="MAEEQARHVKNGLECIRALKAEPIGSLAVEEAMAAWSEISDNPG
QDRATCKEEEAGSSGLSKPCLSAIGSTEGGAPRIRGQGSGESDDDAETLGIPSRNLQA
SSTGLQCYHVYDHSGEAVKGIQDADSIMVQSGLDGDSTLSGGDDESENSDVDIGEPDT
EGYAITDRGSAPISMGFRASDVETAEGGEIHELLKLQSRGNNFPKLGKTLNVPPPPNP
SRASTSETPIKKGTDARLASFGTEIASLLTGGATQCARKSPSEPSGPGAPAGNVPECV
SNAALIQEWTPESGTTISPRSQNNEEGGDYYDDELFSDVQDIKTALAKIHEDNQKIIS
KLESLLLLKGEVESIKKQINRQNISISTLEGHLSSIMIAIPGLGKDPNDPTADVELNP
DLKPIIGRDSGRALAEVLKKPVASRQLQGMTNGRTSSRGQLLKEFQLKPIGKKVSSAV
GFVPDTGPASRSVIRSIIKSSRLEEDRKRYLMTLLDDIKGANDLAKFHQMLMKIIMK"
CDS join(1807..2499,2499..2705)
/gene="V"
/gene_synonym="P"
/experiment="antibody studies of V protein in tissue
culture cells"
/experiment="in vitro translation of synthetic RNA"
/exception="RNA editing"
/note="prevents interferon induced transcriptional
responses in Measles virus; translated from P/V/C mRNA
modified by co-transcriptional insertion of non-templated
G at genome position 2499 nt"
/citation=[3]
/citation=[4]
/codon_start=1
/product="V protein"
/protein_id="YP_003873249.2"
/db_xref="GeneID:1489805"
/translation="MAEEQARHVKNGLECIRALKAEPIGSLAVEEAMAAWSEISDNPG
QDRATCKEEEAGSSGLSKPCLSAIGSTEGGAPRIRGQGSGESDDDAETLGIPSRNLQA
SSTGLQCYHVYDHSGEAVKGIQDADSIMVQSGLDGDSTLSGGDDESENSDVDIGEPDT
EGYAITDRGSAPISMGFRASDVETAEGGEIHELLKLQSRGNNFPKLGKTLNVPPPPNP
SRASTSETPIKKGHRREIGLIWNGDRVFIDRWCNPMCSKVTLGTIRARCTCGECPRVC
EQCRTDTGVDTRIWYHNLPEIPE"
CDS 1829..2389
/gene="C"
/gene_synonym="P"
/experiment="antibody studies of C protein in tissue
culture cells"
/note="prevents interferon-induced transcriptional
responses; acts as infectivity factor; inhibits
transcription; translated from overlapping reading frame
in P/V/C mRNA using alternative start site"
/citation=[6]
/codon_start=1
/product="C protein"
/protein_id="NP_056920.1"
/db_xref="GeneID:1489805"
/translation="MSKTDWNASGLSRPSPSAHWPSRKPWQHGQKYQTTQDRTEPPAR
KRRQAVRVSANHASQQLDQLKAVHLASAVRDLEKAMTTLKLWESPQEISRHQALGYSV
IMFMITAVKRLRESKMLTLSWFNQALMVIAPSQEETMNLKTAMWILANLIPRDMLSLT
GDLLPSLWGSGLLMLKLQKEGRSTSS"
CDS 3438..4445
/gene="M"
/note="hydrophobic protein on inner leaflet of membrane;
inhibits transcription"
/codon_start=1
/product="matrix protein"
/protein_id="NP_056921.1"
/db_xref="GeneID:1489803"
/translation="MTEIYDFDKSAWDIKGSIAPIQPTTYSDGRLVPQVRVIDPGLGD
RKDECFMYMFLLGVVEDSDPLGPPIGRAFGSLPLGVGRSTAKPEELLKEATELDIVVR
RTAGLNEKLVFYNNTPLTLLTPWRKVLTTGSVFNANQVCNAVNLIPLDTPQRFRVVYM
SITRLSDNGYYTVPRRMLEFRSVNAVAFNLLVTLRIDKAIGPGKIIDNAEQLPEATFM
VHIGNFRRKKSEVYSADYCKMKIEKMGLVFALGGIGGTSLHIRSTGKMSKTLHAQLGF
KKTLCYPLMDINEDLNRLLWRSRCKIVRIQAVLQPSVPQEFRIYDDVIINDDQGLFKV
L"
CDS 5458..7110
/gene="F"
/note="type I transmembrane glycoprotein; synthesized as
precurser peptide F0; cleaved to a disulphide linked F1-F2
complex by furin-like protease; acylated"
/codon_start=1
/product="fusion protein"
/protein_id="NP_056922.1"
/db_xref="GeneID:1489800"
/translation="MGLKVNVSAIFMAVLLTLQTPTGQIHWGNLSKIGVVGIGSASYK
VMTRSSHQSLVIKLMPNITLLNNCTRVEIAEYRRLLRTVLEPIRDALNAMTQNIRPVQ
SVASSRRHKRFAGVVLAGAALGVATAAQITAGIALHQSMLNSQAIDNLRASLETTNQA
IEAIRQAGQEMILAVQGVQDYINNELIPSMNQLSCDLIGQKLGLKLLRYYTEILSLFG
PSLRDPISAEISIQALSYALGGDINKVLEKLGYSGGDLLGILESRGIKARITHVDTES
YFIVLSIAYPTLSEIKGVIVHRLEGVSYNIGSQEWYTTVPKYVATQGYLISNFDESSC
TFMPEGTVCSQNALYPMSPLLQECLRGSTKSCARTLVSGSFGNRFILSQGNLIANCAS
ILCKCYTTGTIINQDPDKILTYIAADHCPVVEVNGVTIQVGSRRYPDAVYLHRIDLGP
PISLERLDVGTNLGNAIAKLEDAKELLESSDQILRSMKGLSSTSIVYILIAVCLGGLI
GIPALICCCRGRCNKKGEQVGMSRPGLKPDLTGTSKSYVRSL"
CDS 7271..9124
/gene="H"
/note="type II transmembrane glycoprotein; attachment
glycoprotein that interacts directly with entry receptors"
/codon_start=1
/product="hemagglutinin protein"
/protein_id="NP_056923.1"
/db_xref="GeneID:1489801"
/translation="MSPQRDRINAFYKDNPHPKGSRIVINREHLMIDRPYVLLAVLFV
MFLSLIGLLAIAGIRLHRAAIYTAEIHKSLSTNLDVTNSIEHQVKDVLTPLFKIIGDE
VGLRTPQRFTDLVKFISDKIKFLNPDREYDFRDLTWCINPPERIKLDYDQYCADVAAE
ELMNALVNSTLLEARATNQFLAVSKGNCSGPTTIRGQFSNMSLSLLDLYLSRGYNVSS
IVTMTSQGMYGGTYLVGKPNLSSKGSELSQLSMHRVFEVGVIRNPGLGAPVFHMTNYF
EQPVSNDFSNCMVALGELKFAALCHREDSITIPYQGSGKGVSFQLVKLGVWKSPTDMR
SWVPLSTDDPVIDRLYLSSHRGVIADNQAKWAVPTTRTDDKLRMETCFQQACKGKNQA
LCENPEWAPLKDNRIPSYGVLSVNLSLTVELKIKIASGFGPLITHGSGMDLYKTNHNN
VYWLTIPPMKNLALGVINTLEWIPRFKVSPNLFTVPIKEAGEDCHAPTYLPAEVDGDV
KLSSNLVILPGQDLQYVLATYDTSRVEHAVVYYVYSPSRSFSYFYPFRLPIKGVPIEL
QVECFTWDKKLWCRHFCVLADSESGGHITHSGMVGMGVSCTVTREDGTNRR"
CDS 9234..15785
/gene="L"
/note="large subunit of RNA dependent RNA polymerase
(RdRp); RNA synthesis, capping, and polyadenylation"
/codon_start=1
/product="large polymerase protein"
/protein_id="NP_056924.1"
/db_xref="GeneID:1489802"
/translation="MDSLSVNQILYPEVHLDSPIVTNKIVAILEYARVPHAYSLEDPT
LCQNIKHRLKNGFSNQMIINNVEVGNVIKSKLRSYPAHSHIPYPNCNQDLFNIEDKES
TRKIRELLKKGNSLYSKVSDKVFQCLRDTNSRLGLGSELREDIKEKIINLGVYMHSSQ
WFEPFLFWFTVKTEMRSVIKSQTHTCHRRRHTPVFFTGSSVELLISRDLVAIISKESQ
HVYYLTFELVLMYCDVIEGRLMTETAMTIDARYAELLGRVRYMWKLIDGFFPALGNPT
YQIVAMLEPLSLAYLQLRDITVELRGAFLNHCFTEIHDVLDQNGFSDEGTYHELIEAL
DYIFITDDIHLTGEIFSFFRSFGHPRLEAVTAAENVRKYMNQPKVIVYETLMKGHAIF
CGIIINGYRDRHGGSWPPLTLPLHAADTIRNAQASGEGLTHEQCVDNWKSFAGVRFGC
FMPLSLDSDLTMYLKDKALAALQREWDSVYPKEFLRYDPPKGTGSRRLVDVFLNDSSF
DPYDMIMYVVSGAYLHDPEFNLSYSLKEKEIKETGRLFAKMTYKMRACQVIAENLISN
GIGKYFKDNGMAKDEHDLTKALHTLAVSGVPKDLKESHRGGPVLKTYSRSPVHTSTRN
VKAEKGFVGFPHVIRQNQDTDHPENIETYETVSAFITTDLKKYCLNWRYETISLFAQR
LNEIYGLPSFFQWLHKRLETSVLYVSDPHCPPDLDAHVPLCKVPNDQIFIKYPMGGIE
GYCQKLWTISTIPYLYLAAYESGVRIASLVQGDNQTIAVTKRVPSTWPYNLKKREAAR
VTRDYFVILRQRLHDIGHHLKANETIVSSHFFVYSKGIYYDGLLVSQSLKSIARCVFW
SETIVDETRAACSNIATTMAKSIERGYDRYLAYSLNVLKVIQQILISLGFTINSTMTR
DVVIPLLTNNDLLIRMALLPAPIGGMNYLNMSRLFVRNIGDPVTSSIADLKRMILASL
MPEETLHQVMTQQPGDSSFLDWASDPYSANLVCVQSITRLLKNITARFVLIHSPNPML
KGLFHDDSKEEDERLAAFLMDRHIIVPRAAHEILDHSVTGARESIAGMLDTTKGLIRA
SMRKGGLTSRVITRLSNYDYEQFRAGMVLLTGRKRNVLIDKESCSVQLARALRSHMWA
RLARGRPIYGLEVPDVLESMRGHLIRRHETCVICECGSVNYGWFFVPSGCQLDDIDKE
TSSLRVPYIGSTTDERTDMKLAFVRAPSRSLRSAVRIATVYSWAYGDDDSSWNEAWLL
ARQRANVSLEELRVITPISTSTNLAHRLRDRSTQVKYSGTSLVRVARYTTISNDNLSF
VISDKKVDTNFIYQQGMLLGLGVLETLFRLEKDTGSSNTVLHLHVETDCCVIPMIDHP
RIPSSRKLELRAELCTNPLIYDNAPLIDRDATRLYTQSHRRHLVEFVTWSTPQLYHIL
AKSTALSMIDLVTKFEKDHMNEISALIGDDDINSFITEFLLIEPRLFTIYLGQCAAIN
WAFDVHYHRPSGKYQMGELLSSFLSRMSKGVFKVLVNALSHPKIYKKFWHCGIIEPIH
GPSLDAQNLHTTVCNMVYTCYMTYLDLLLNEELEEFTFLLCESDEDVVPDRFDNIQAK
HLCVLADLYCQPGTCPPIRGLRPVEKCAVLTDHIKAEARLSPAGSSWNINPIIVDHYS
CSLTYLRRGSIKQIRLRVDPGFIFDALAEVNVSQPKVGSNNISNMSIKDFRPPHDDVA
KLLKDINTSKHNLPISGGSLANYEIHAFRRIGLNSSACYKAVEISTLIRRCLEPGEDG
LFLGEGSGSMLITYKEILKLNKCFYNSGVSANSRSGQRELAPYPSEVGLVEHRMGVGN
IVKVLFNGRPEVTWVGSIDCFNFIVSNIPTSSVGFIHSDIETLPNKDTIEKLEELAAI
LSMALLLGKIGSILVIKLMPFSGDFVQGFISYVGSHYREVNLVYPRYSNFISTESYLV
MTDLKANRLMNPEKIKQQIIESSVRTSPGLIGHILSIKQLSCIQAIVGGAVSRGDINP
ILKKLTPIEQVLISCGLAINGPKLCKELIHHDVASGQDGLLNSILILYRELARFKDNQ
RSQQGMFHAYPVLVSSRQRELVSRITRKFWGHILLYSGNRKLINRFIQNLKSGYLVLD
LHQNIFVKNLSKSEKQIIMTGGLKREWVFKVTVKETKEWYKLVGYSALIKD"
ORIGIN
1 accaaacaaa gttgggtaag gatagatcaa tcaatgatca tattctagta cacttaggat
61 tcaagatcct attatcaggg acaagagcag gattagggat atccgagatg gccacacttt
121 tgaggagctt agcattgttc aaaagaaaca aggacaaacc acccattaca tcaggatccg
181 gtggagccat cagaggaatc aaacacatta ttatagtacc aattcctgga gattcctcaa
241 ttaccactcg atccagacta ctggaccggt tggtcaggtt aattggaaac ccggatgtga
301 gcgggcccaa actaacaggg gcactaatag gtatattatc cttatttgtg gagtctccag
361 gtcaattgat tcagaggatc accgatgacc ctgacgttag catcaggctg ttagaggttg
421 ttcagagtga ccagtcacaa tctggcctta ccttcgcatc aagaggtacc aacatggagg
481 atgaggcgga ccaatacttt tcacatgatg atccaagcag tagtgatcaa tccaggtccg
541 gatggttcga gaacaaggaa atctcagata ttgaagtgca agaccctgag ggattcaaca
601 tgattctggg taccattcta gcccagatct gggtcttgct cgcaaaggcg gttacggccc
661 cagacacggc agctgattcg gagctaagaa ggtggataaa gtacacccaa caaagaaggg
721 tagttggtga atttagattg gagagaaaat ggttggatgt ggtgaggaac aggattgccg
781 aggacctctc tttacgccga ttcatggtgg ctctaatcct ggatatcaag aggacacccg
841 ggaacaaacc taggattgct gaaatgatat gtgacattga tacatatatc gtagaggcag
901 gattagccag ttttatcctg actattaagt ttgggataga aactatgtat cctgctcttg
961 gactgcatga atttgctggt gagttatcca cacttgagtc cttgatgaat ctttaccagc
1021 aaatgggaga aactgcaccc tacatggtaa tcctagagaa ctcaattcag aacaagttca
1081 gtgcaggatc ataccctctg ctctggagct atgccatggg agtaggagtg gaacttgaaa
1141 actccatggg aggtttgaac tttggtcgat cttactttga tccagcatat tttagattag
1201 ggcaagagat ggtgaggagg tcagctggaa aggtcagttc cacattggca tccgaactcg
1261 gtatcactgc cgaggatgca aggcttgttt cagagattgc aatgcatact actgaggaca
1321 ggatcagtag agcggtcgga cccagacaag cccaagtgtc atttctacac ggtgatcaaa
1381 gtgagaatga gctaccagga ttggggggca aggaagatag gagggtcaaa cagggtcggg
1441 gagaagccag ggagagctac agagaaaccg ggtccagcag agcaagtgat gcgagagctg
1501 cccatcctcc aaccagcatg cccctagaca ttgacactgc atcggagtca ggccaagatc
1561 cgcaggacag tcgaaggtca gctgacgccc tgctcaggct gcaagccatg gcaggaatct
1621 tggaagaaca aggctcagac acggacaccc ctagggtata caatgacaga gatcttctag
1681 actaggtgcg agaggccgag gaccagaaca acatccgcct accctccatc attgttataa
1741 aaaacttagg aaccaggtcc acacagccgc cagccaacca accatccact cccacgactg
1801 gagccgatgg cagaagagca ggcacgccat gtcaaaaacg gactggaatg catccgggct
1861 ctcaaggccg agcccatcgg ctcactggcc gtcgaggaag ccatggcagc atggtcagaa
1921 atatcagaca acccaggaca ggaccgagcc acctgcaagg aagaggaggc aggcagttcg
1981 ggtctcagca aaccatgcct ctcagcaatt ggatcaactg aaggcggtgc acctcgcatc
2041 cgcggtcagg gatctggaga aagcgatgac gacgctgaaa ctttgggaat cccctcaaga
2101 aatctccagg catcaagcac tgggttacag tgttatcatg tttatgatca cagcggtgaa
2161 gcggttaagg gaatccaaga tgctgactct atcatggttc aatcaggcct tgatggtgat
2221 agcaccctct caggaggaga cgatgaatct gaaaacagcg atgtggatat tggcgaacct
2281 gataccgagg gatatgctat cactgaccgg ggatctgctc ccatctctat ggggttcagg
2341 gcttctgatg ttgaaactgc agaaggaggg gagatccacg agctcctgaa actccaatcc
2401 agaggcaaca actttccgaa gcttgggaaa actctcaatg ttcctccgcc cccgaacccc
2461 agtagggcca gcacttccga gacacccatt aaaaagggca cagacgcgag attggcctca
2521 tttggaacgg agatcgcgtc tttattgaca ggtggtgcaa cccaatgtgc tcgaaagtca
2581 ccctcggaac catcagggcc aggtgcacct gcggggaatg tccccgagtg tgtgagcaat
2641 gccgcactga tacaggagtg gacacccgaa tctggtacca caatctcccc gagatcccag
2701 aataatgaag aagggggaga ctattatgat gatgagctgt tctccgatgt ccaagacatc
2761 aaaacagcct tggccaaaat acacgaggat aatcagaaga taatctccaa gctagaatca
2821 ttgctgttat tgaagggaga agttgagtca attaagaagc agatcaacag gcaaaatatc
2881 agcatatcca ccctggaagg acacctctca agcatcatga ttgccattcc tggacttggg
2941 aaggatccca acgaccccac tgcagatgtc gaactcaatc ccgacctgaa acccatcata
3001 ggcagagatt caggccgagc actggccgaa gttctcaaga agcccgttgc cagccgacaa
3061 ctccagggaa tgactaatgg acggaccagt tccagaggac agctgctgaa ggaatttcaa
3121 ctaaagccga tcgggaaaaa ggtgagctca gccgtcgggt ttgttcctga caccggccct
3181 gcatcacgca gtgtaatccg ctccattata aaatccagcc ggctagagga ggatcggaag
3241 cgttacctga tgactctcct tgatgatatc aaaggagcca acgatcttgc caagttccac
3301 cagatgctga tgaagataat aatgaagtag ctacagctca acttacctgc caaccccatg
3361 ccagtcgacc taattagtac aacctaaatc cattataaaa aacttaggag caaagtgatt
3421 gcctcctaag ttccacaatg acagagatct acgatttcga caagtcggca tgggacatca
3481 aagggtcgat cgctccgata caacctacca cctacagtga tggcaggctg gtgccccagg
3541 tcagagtcat agatcctggt ctaggtgata ggaaggatga atgctttatg tacatgtttc
3601 tgctgggggt tgttgaggac agcgatcccc tagggcctcc aatcgggcga gcattcgggt
3661 ccctgccctt aggtgttggt agatccacag caaaacccga ggaactcctc aaagaggcca
3721 ctgagcttga catagttgtt agacgtacag cagggctcaa tgaaaaactg gtgttctaca
3781 acaacacccc actaaccctc ctcacacctt ggagaaaggt cctaacaaca gggagtgtct
3841 tcaatgcaaa ccaagtgtgc aatgcggtta atctaatacc gctggacacc ccgcagaggt
3901 tccgtgttgt ttatatgagc atcacccgtc tttcggataa cgggtattac accgttccca
3961 gaagaatgct ggaattcaga tcggtcaatg cagtggcctt caacctgcta gtgaccctta
4021 ggattgacaa ggcgattggc cctgggaaga tcatcgacaa tgcagagcaa cttcctgagg
4081 caacatttat ggtccacatc gggaacttca ggagaaagaa gagtgaagtc tactctgccg
4141 attattgcaa aatgaaaatc gaaaagatgg gcctggtttt tgcacttggt gggatagggg
4201 gcaccagtct tcacattaga agcacaggca aaatgagcaa gactctccat gcacaactcg
4261 ggttcaagaa gaccttatgt tacccactga tggatatcaa tgaagacctt aatcggttac
4321 tctggaggag cagatgcaag atagtaagaa tccaggcagt tttgcagcca tcagttcctc
4381 aagaattccg catttacgac gacgtgatca taaatgatga ccaaggacta ttcaaagttc
4441 tgtagaccgc agtgcccagc aatacccgaa aacgaccccc ctcataatga cagccagaag
4501 gcccggacaa aaaagccccc tccagaagac tccacggacc aagcgagagg ccagccagca
4561 gccgacagca agtgtggaca ccaggcggcc caagcacaga acagccccga cacaaggcca
4621 ccaccagcca tcccaatctg cgtcctcctc gtgggacccc cgaggaccaa ccccgaaggt
4681 cgctccgaac acagaccacc aaccgcatcc ccacagctcc cgggaaagga acccccagca
4741 actggaaggc ccctcccccc ctcccccaac gcaagaaccc cacaaccgaa ccgcacaagc
4801 gaccgaggtg acccaaccgc aggcatccga ctccttagac agatcctctc cccccggcat
4861 actaaacaaa acttagggcc aaggaacaca cacactcgac agaacccaga ccccggcccg
4921 cggcaccgcg cccccacccc ccgaaaacca gagggagccc ccaaccaaac ccgccggccc
4981 ccccggtgcc cacaggtagg cacaccaacc cccgaccaga cccagcaccc agccaccgac
5041 aatccaagac ggggggcccc ccccaaaaaa aggcccccag gggccgacag ccagcatcgc
5101 gaggaagcac acccacccca cacacgacca cggcaaccga accagagtcc agaccaccct
5161 gggccaccag ctcccagact cggccatcac cccgcaaaaa ggaaaggcca caacccgcgc
5221 accccagccc cgatccggcg ggcagccact caacccgaac cagcacccaa gagcgatccc
5281 tgggggaccc ccaaaccgca aaagacatca gtatcccaca gcctctccaa gtcccccggt
5341 ctcctcctct tctcgaaggg accaaaagat caatccacca catccgacga cactcaattc
5401 cccaccccca aaggagacac cgggaatccc agaatcaaga ctcatccagt gtccatcatg
5461 ggtctcaagg tgaacgtctc tgccatattc atggcagtac tgttaactct ccaaacaccc
5521 accggtcaaa tccattgggg caatctctct aagatagggg tggtagggat aggaagtgca
5581 agctacaaag ttatgactcg ttccagccat caatcattgg tcataaaatt aatgcccaat
5641 ataactctcc tcaataactg cacgagggta gagatcgcag aatacaggag actactgaga
5701 acagttttgg aaccaattag agatgcactt aatgcaatga cccagaatat aagaccggtt
5761 cagagtgtag cttcaagtag gagacacaag agatttgcgg gagttgtcct ggcaggtgcg
5821 gccctaggcg ttgccacagc tgctcagata acagccggca ttgcacttca ccagtccatg
5881 ctgaactctc aagccatcga caatctgaga gcaagcctgg aaactactaa tcaggcaatt
5941 gaggcaatca gacaagcagg gcaggagatg atattggctg ttcagggtgt ccaagactac
6001 atcaataatg agctgatacc gtctatgaac caactatctt gtgatttaat cggccagaag
6061 ctagggctca aattgctcag atactataca gaaatcctgt cattatttgg ccccagctta
6121 cgggacccca tatctgcgga gatatccatc caggctttga gctatgcgct tggaggagat
6181 atcaataagg tattagaaaa gctcggatac agtggaggtg atttactggg catcttagag
6241 agcagaggaa taaaggcccg gataactcac gtcgacacag agtcctactt cattgtactc
6301 agtatagcct atccgacgct gtccgagatt aagggggtga ttgtccaccg gctagagggg
6361 gtctcgtaca atataggctc tcaagagtgg tataccactg tgcccaagta tgttgcaacc
6421 caagggtacc ttatctcgaa ttttgatgag tcatcgtgta ctttcatgcc agaggggact
6481 gtgtgcagcc aaaatgcctt gtacccgatg agtcctctgc tccaagaatg cctccggggg
6541 tccaccaagt cctgtgctcg tacactcgta tccgggtctt ttgggaaccg gttcatttta
6601 tcacaaggga acctaatagc caattgtgca tcaatcctct gcaagtgtta cacaacagga
6661 acgatcatta atcaagaccc tgacaagatc ctaacataca ttgctgccga tcactgcccg
6721 gtggtcgagg tgaacggtgt gaccatccaa gtcgggagca ggaggtatcc ggacgcggtg
6781 tacctgcaca gaattgacct cggtcctccc atatcattgg agaggttgga cgtagggaca
6841 aatctgggga atgcaattgc taagttggag gatgccaagg aattgttgga gtcatcggac
6901 cagatattga ggagtatgaa aggtttatcg agcactagca tagtttacat cctgattgca
6961 gtgtgtcttg gagggttgat agggatcccc gctttaatat gttgctgcag ggggcgctgt
7021 aacaaaaagg gagaacaagt tggtatgtca agaccaggcc taaagcctga tcttacaggg
7081 acatcaaaat cctatgtaag gtcgctctga tcctctacaa ctcttgaaac acagatttcc
7141 cacaagtctc ctcttcgtca tcaagcaacc accgcatcca gcatcaagcc cacctgaaat
7201 tgtctccggc ttccctctgg ccgaacgata tcggtagtta attaaaactt agggtgcaag
7261 atcatccaca atgtcaccac aacgagaccg aataaatgcc ttctacaaag acaacccaca
7321 tcctaaggga agtaggatag ttattaacag agaacatctt atgattgata gaccttatgt
7381 tttgctggct gttctattcg tcatgtttct gagcttgatc gggttgctag ccattgcagg
7441 cattagactc catcgtgcag ccatctacac cgcagagatc cataagagcc tcagcaccaa
7501 tctagatgta actaactcga tcgagcatca ggtcaaggac gtgctgacac cactcttcaa
7561 gatcattggt gatgaagtgg gcctgaggac acctcagaga ttcactgacc tagtgaaatt
7621 catctctgac aaaattaaat tccttaatcc ggatagggag tacgacttca gagatctcac
7681 ttggtgtatc aacccgccag agagaatcaa attggattat gatcaatact gtgcagatgt
7741 ggctgctgaa gaactcatga atgcattggt gaactcaact ctactggagg ccagggcaac
7801 caatcagttc ctagctgtct caaagggaaa ctgctcaggg cccactacaa tcagaggtca
7861 attctcaaac atgtcgctgt ccctgttgga cttgtattta agtcgaggtt acaatgtgtc
7921 atctatagtc actatgacat cccagggaat gtacggggga acttacctag tgggaaagcc
7981 taatctgagc agtaaagggt cagagttgtc acaactgagc atgcaccgag tgtttgaagt
8041 aggggttatc agaaatccgg gtttgggggc tccggtgttc catatgacaa actattttga
8101 gcaaccagtc agtaatgatt tcagcaactg catggtggct ttgggggagc ttaaattcgc
8161 agccctctgt cacagggaag attctatcac aattccctat caggggtcag ggaaaggtgt
8221 cagcttccag ctcgtcaagc taggtgtctg gaaatcccca accgacatgc gatcctgggt
8281 ccccctatca acggatgatc cagtgataga taggctttac ctctcatctc acagaggtgt
8341 tatcgctgac aatcaagcaa aatgggctgt cccgacaaca cggacagatg acaagttgcg
8401 aatggagaca tgcttccagc aggcgtgtaa gggtaaaaac caagcactct gcgagaatcc
8461 cgagtgggca ccattgaagg ataacaggat tccttcatac ggggtcttgt ctgttaatct
8521 gagtctgaca gttgagctta aaatcaaaat tgcttcagga ttcgggccat tgatcacaca
8581 cggttcaggg atggacctat acaaaaccaa ccacaacaat gtgtattggc tgactatccc
8641 gccaatgaag aacctagcct taggtgtaat caacacattg gagtggatac cgagattcaa
8701 ggttagtccc aacctcttca ctgttccaat caaggaagca ggcgaggact gccatgcccc
8761 aacataccta cctgcggagg tggatggtga tgtcaaactc agttccaatc tggtaattct
8821 acctggtcag gatctccaat atgttttggc aacctacgat acttccaggg ttgaacatgc
8881 tgtggtttat tatgtttaca gcccaagccg ctcattttct tacttttatc cttttaggtt
8941 gcctataaag ggggtcccaa tcgaattaca agtggaatgc ttcacatggg acaaaaaact
9001 ctggtgccgt cacttctgtg tgcttgcgga ctcagaatct ggtggacata tcactcactc
9061 tgggatggtg ggcatgggag tcagctgcac agtcactcgg gaagatggaa ccaatcgcag
9121 atagggctgc cagtgaaccg atcacatgat gtcacccaga catcaggcat acccactagt
9181 gtgaaataga catcagaatt aagaaaaacg tagggtccaa gtggtttccc gttatggact
9241 cgctatctgt caaccagatc ttataccctg aagttcacct agatagcccg atagttacca
9301 ataagatagt agctatcctg gagtatgctc gagtccctca cgcttacagc ctggaggacc
9361 ctacactgtg tcagaacatc aagcaccgcc taaaaaacgg attctccaac caaatgatta
9421 taaacaatgt ggaagttggg aatgtcatca agtccaagct taggagttat ccggcccact
9481 ctcatattcc atatccaaat tgtaatcagg atttatttaa catagaagac aaagagtcaa
9541 caaggaagat ccgtgagctc ctaaaaaagg gaaattcgct gtactccaaa gtcagtgata
9601 aggttttcca atgcctgagg gacactaact cacggcttgg cctaggctcc gaattgaggg
9661 aggacatcaa ggagaaaatt attaacttgg gagtttacat gcacagctcc caatggtttg
9721 agccctttct gttttggttt acagtcaaga ctgagatgag gtcagtgatt aaatcacaaa
9781 cccatacttg ccataggagg agacacacac ctgtattctt cactggtagt tcagttgagc
9841 tgttaatctc tcgtgacctt gttgctataa tcagtaagga gtctcaacat gtatattacc
9901 tgacgtttga actggttttg atgtattgtg atgtcataga ggggaggtta atgacagaga
9961 ccgctatgac cattgatgct aggtatgcag aacttctagg aagagtcaga tacatgtgga
10021 aactgataga tggtttcttc cctgcactcg ggaatccaac ttatcaaatt gtagccatgc
10081 tggagccact ttcacttgct tacctgcaac tgagggatat aacagtagaa ctcagaggtg
10141 ctttccttaa ccactgcttt actgaaatac atgatgttct tgaccaaaac gggttttctg
10201 atgaaggtac ttatcatgag ttaattgaag ccctagatta cattttcata actgatgaca
10261 tacatctgac aggggagatt ttctcatttt tcagaagttt cggccacccc agacttgaag
10321 cagtaacggc tgctgaaaat gtcaggaaat acatgaatca gcctaaagtc attgtgtatg
10381 agactctgat gaaaggtcat gccatatttt gtggaatcat aatcaacggc tatcgtgaca
10441 ggcacggagg cagttggcca cccctgaccc tccccctgca tgctgcagac acaatccgga
10501 atgctcaagc ttcaggtgaa gggttaacac atgagcagtg cgttgataac tggaaatcat
10561 ttgctggagt gagatttggc tgttttatgc ctcttagcct ggacagtgat ctgacaatgt
10621 acctaaagga caaggcactt gctgctctcc aaagggaatg ggattcagtt tacccgaaag
10681 agttcctgcg ttacgatcct cccaagggaa ccgggtcacg gaggcttgta gatgttttcc
10741 ttaatgattc gagctttgac ccatatgata tgataatgta tgtcgtaagt ggagcctacc
10801 tccatgaccc tgagttcaac ctgtcttaca gcctgaaaga aaaggagatc aaggaaacag
10861 gtagactttt cgctaaaatg acttacaaaa tgagggcatg ccaagtgatc gctgaaaatc
10921 taatctcaaa cgggattggc aagtatttta aggacaatgg gatggccaag gatgagcacg
10981 atttgactaa ggcactccac actctggctg tctcaggagt ccccaaagat ctcaaagaaa
11041 gtcacagggg ggggccagtc ttaaaaacct actcccgaag cccagtccac acaagtacca
11101 ggaacgttaa agcagaaaaa gggtttgtag gattccctca tgtaattcgg cagaatcaag
11161 acactgatca tccggagaat atagaaacct acgagacagt cagcgcattt atcacgactg
11221 atctcaagaa gtactgcctt aattggagat atgagaccat cagcttattt gcacagaggc
11281 taaatgagat ttacggatta ccctcatttt ttcagtggct gcataagagg cttgaaacct
11341 ctgtcctcta tgtaagtgac cctcattgcc cccccgacct tgacgcccat gtcccgttat
11401 gcaaagtccc caatgaccaa atcttcatca agtaccctat gggaggtata gaagggtatt
11461 gtcagaagct gtggaccatc agcaccattc cctacttata cctggctgct tatgagagcg
11521 gggtaaggat tgcttcgtta gtgcaagggg acaatcagac catagccgta acaaaaaggg
11581 tacccagcac atggccttac aaccttaaga aacgggaagc tgctagagta actagagatt
11641 actttgtaat tcttaggcaa aggctacatg acattggcca tcacctcaag gcaaatgaga
11701 caattgtttc atcacatttt tttgtctatt caaaaggaat atattatgat gggctacttg
11761 tgtcccaatc actcaagagc atcgcaagat gtgtattctg gtcagagact atagttgatg
11821 aaacaagggc agcatgcagt aatattgcta caacaatggc taaaagcatc gagagaggtt
11881 atgaccgtta tcttgcatat tccctgaacg tcctaaaagt gatacagcaa attttgatct
11941 ctcttggctt cacaatcaat tcaaccatga cccgagatgt agtcataccc ctcctcacaa
12001 acaacgatct cttaataagg atggcactgt tgcccgctcc tattgggggg atgaattatc
12061 tgaatatgag caggctgttt gtcagaaaca tcggtgatcc agtaacatca tcaattgctg
12121 atctcaagag aatgattctc gcatcactaa tgcctgaaga gaccctccat caagtaatga
12181 cacaacaacc gggggactct tcattcctag actgggctag cgacccttac tcagcaaatc
12241 ttgtatgcgt ccagagcatc actagactcc tcaagaacat aactgcaagg tttgtcctaa
12301 tccatagtcc aaacccaatg ttaaaagggt tattccatga tgacagtaaa gaagaggacg
12361 agagactggc ggcattcctc atggacaggc atattatagt acctagggca gctcatgaaa
12421 tcctggatca tagtgtcaca ggggcaagag agtctattgc aggcatgcta gataccacaa
12481 aaggcctgat tcgagccagc atgaggaagg gggggttaac ctctcgagtg ataaccagat
12541 tgtccaatta tgactatgaa caatttagag cagggatggt gctattgaca ggaagaaaga
12601 gaaatgtcct cattgacaaa gagtcatgtt cagtgcagct ggctagagcc ctaagaagcc
12661 atatgtgggc aagactagct cgaggacggc ctatttacgg ccttgaggtc cctgatgtac
12721 tagaatctat gcgaggccac cttattcggc gtcatgagac atgtgtcatc tgcgagtgtg
12781 gatcagtcaa ctacggatgg ttttttgtcc cctcgggttg ccaactggat gatattgaca
12841 aggaaacatc atccttgaga gtcccatata ttggttctac cactgatgag agaacagaca
12901 tgaagctcgc cttcgtaaga gccccaagta gatccttgcg atctgccgtt agaatagcaa
12961 cagtgtactc atgggcttac ggtgatgatg atagctcttg gaacgaagcc tggttgttgg
13021 caaggcaaag ggccaatgtg agcctggagg agctaagggt gatcactccc atctcgactt
13081 cgactaattt agcgcatagg ttgagggatc gtagcactca agtgaaatac tcaggtacat
13141 cccttgtccg agtggcaagg tataccacaa tctccaacga caatctctca tttgtcatat
13201 cagataagaa ggttgatact aactttatat accaacaagg aatgcttcta gggttgggtg
13261 ttttagaaac attgtttcga ctcgagaaag atactggatc atctaacacg gtattacatc
13321 ttcacgtcga aacagattgt tgcgtgatcc cgatgataga tcatcccagg atacccagct
13381 cccgcaagct agagctgagg gcagagctat gtaccaaccc attgatatat gataatgcac
13441 ctttaattga cagagatgca acaaggctat acacccagag ccataggagg caccttgtgg
13501 aatttgttac atggtccaca ccccaactat atcacattct agctaagtcc acagcactat
13561 ctatgattga cctggtaaca aaatttgaga aggaccatat gaatgaaatt tcagctctca
13621 taggggatga cgatatcaat agtttcataa ctgagtttct gcttatagag ccaagattat
13681 tcaccatcta cttgggccag tgtgcagcca tcaattgggc atttgatgta cattatcata
13741 gaccatcagg gaaatatcag atgggtgagc tgttgtcttc gttcctttct agaatgagca
13801 aaggagtgtt taaggtgctt gtcaatgctc taagccaccc aaagatctac aagaaattct
13861 ggcattgtgg tattatagag cctatccatg gtccttcact tgatgctcaa aacttgcaca
13921 caactgtgtg caacatggtt tacacatgct atatgaccta cctcgacctg ttgttgaatg
13981 aagagttaga agagttcaca tttcttttgt gtgaaagcga tgaggatgta gtaccggaca
14041 gattcgacaa catccaggca aaacacttgt gtgttctggc agatttgtac tgtcaaccag
14101 ggacctgccc accgattcga ggtctaaggc cggtagagaa atgtgcagtt ctaaccgatc
14161 atatcaaggc agaggctagg ttatctccag caggatcttc gtggaacata aatccaatta
14221 ttgtagacca ttactcatgc tctctgactt atctccgtcg aggatctatc aaacagataa
14281 gattgagagt tgatccagga ttcatttttg acgccctcgc tgaggtaaat gtcagtcagc
14341 caaaggtcgg cagcaacaac atctcaaata tgagcatcaa ggatttcaga cctccacacg
14401 atgatgttgc aaaattgctc aaagatatca acacaagcaa gcacaatctt cccatttcag
14461 ggggtagtct cgccaattat gaaatccatg ctttccgcag aatcgggtta aactcatctg
14521 cttgctacaa agctgttgag atatcaacat taattaggag atgccttgag ccaggggaag
14581 acggcttgtt cttgggtgag gggtcgggtt ctatgttgat cacttataag gagatactaa
14641 aactaaacaa gtgcttctat aatagtgggg tttccgccaa ttctagatct ggtcaaaggg
14701 aattagcacc ctatccctcc gaagttggcc ttgtcgaaca cagaatggga gtaggtaata
14761 ttgtcaaggt gctctttaac gggaggcccg aagtcacgtg ggtaggcagt atagattgct
14821 tcaatttcat agtcagtaat atccctacct ctagtgtggg gtttatccat tcagatatag
14881 agaccttacc taacaaagat actatagaga agctagagga attggcagcc atcttatcga
14941 tggctctact ccttggcaaa ataggatcaa tactggtgat taagcttatg cctttcagcg
15001 gggattttgt tcagggattt ataagctatg tagggtctca ttatagagaa gtgaaccttg
15061 tctaccctag gtacagcaac ttcatatcta ctgaatctta tttagttatg acagatctca
15121 aagctaaccg gctaatgaat cctgaaaaga tcaagcagca gataattgaa tcatctgtgc
15181 ggacttcacc tggacttata ggtcacatcc tatccattaa gcaactaagc tgcatacaag
15241 caattgtggg aggcgcagtt agtagaggtg atatcaaccc tattctgaaa aaacttacac
15301 ctatagagca ggtgctgatc agttgcgggt tggcaattaa cggacctaaa ctgtgcaaag
15361 aattaatcca ccatgatgtt gcctcagggc aagatggatt gcttaactct atactcatcc
15421 tctacaggga gttggcaaga ttcaaagaca accaaagaag tcaacaaggg atgttccacg
15481 cttaccccgt attggtaagt agtaggcaac gagaacttgt atctaggatc actcgcaaat
15541 tttgggggca tattcttctt tactccggga acagaaagtt gataaatcgg tttatccaga
15601 atctcaagtc cggttatcta gtactagact tacaccagaa tatcttcgtt aagaatctat
15661 ccaagtcaga gaaacagatt attatgacgg ggggtttaaa acgtgagtgg gtttttaagg
15721 taacagtcaa ggagaccaaa gaatggtaca agttagtcgg atacagcgct ctgattaagg
15781 attaattggt tgaactccgg aaccctaatc ctgccctagg tagttaggca ttatttgcaa
15841 tatattaaag aaaactttga aaatacgaag tttctattcc cagctttgtc tggt
//