diff --git a/Misc/NEWS.d/next/Library/2024-06-03-11-18-16.gh-issue-117142.kWTXQo.rst b/Misc/NEWS.d/next/Library/2024-06-03-11-18-16.gh-issue-117142.kWTXQo.rst
new file mode 100644
index 00000000000000..80734ef3946300
--- /dev/null
+++ b/Misc/NEWS.d/next/Library/2024-06-03-11-18-16.gh-issue-117142.kWTXQo.rst
@@ -0,0 +1,2 @@
+The :mod:`ctypes` module may now be imported in all subinterpreters, including
+those that have their own GIL.
diff --git a/Modules/_ctypes/_ctypes.c b/Modules/_ctypes/_ctypes.c
index 6c1e5f58b95657..1d9534671a4ee8 100644
--- a/Modules/_ctypes/_ctypes.c
+++ b/Modules/_ctypes/_ctypes.c
@@ -5939,7 +5939,7 @@ module_free(void *module)
 
 static PyModuleDef_Slot module_slots[] = {
     {Py_mod_exec, _ctypes_mod_exec},
-    {Py_mod_multiple_interpreters, Py_MOD_MULTIPLE_INTERPRETERS_SUPPORTED},
+    {Py_mod_multiple_interpreters, Py_MOD_PER_INTERPRETER_GIL_SUPPORTED},
     {Py_mod_gil, Py_MOD_GIL_NOT_USED},
     {0, NULL}
 };