diff --git a/README.md b/README.md
index cc797e2..6d2e5b6 100644
--- a/README.md
+++ b/README.md
@@ -58,6 +58,7 @@ $ mix deps.audit
 | `--format`               | String | `"human"`           | The format of the report to generate (`"json"` or `"human"`) |
 | `--ignore-advisory-ids`  | String | `""`                | Comma-separated list of advisory IDs to ignore               |
 | `--ignore-package-names` | String | `""`                | Comma-separated list of package names to ignore              |
+| `--ignore-file`          | String | `""`                | Path of the ignore file                                      |
 
 ## Example
 
diff --git a/lib/mix_audit/cli.ex b/lib/mix_audit/cli.ex
index 4349a50..a525c65 100644
--- a/lib/mix_audit/cli.ex
+++ b/lib/mix_audit/cli.ex
@@ -5,6 +5,7 @@ defmodule MixAudit.CLI do
         switches: [
           ignore_advisory_ids: :string,
           ignore_package_names: :string,
+          ignore_file: :string,
           version: :boolean,
           help: :boolean,
           format: :string,
diff --git a/lib/mix_audit/cli/audit.ex b/lib/mix_audit/cli/audit.ex
index aeaaf46..4d76ff5 100644
--- a/lib/mix_audit/cli/audit.ex
+++ b/lib/mix_audit/cli/audit.ex
@@ -33,12 +33,32 @@ defmodule MixAudit.CLI.Audit do
   end
 
   defp ignored_advisory_ids(opts) do
+    ignored_ids_from_cli = ignored_advisory_ids_from_cli(opts)
+    ignored_ids_from_file = ignored_advisory_ids_from_file(opts)
+
+    Enum.uniq(ignored_ids_from_cli ++ ignored_ids_from_file)
+  end
+
+  defp ignored_advisory_ids_from_cli(opts) do
     opts
     |> Keyword.get(:ignore_advisory_ids, "")
     |> String.split(",")
     |> Enum.map(&String.trim/1)
   end
 
+  def ignored_advisory_ids_from_file(opts) do
+    case Keyword.get(opts, :ignore_file) do
+      nil ->
+        []
+
+      ignore_file ->
+        ignore_file
+        |> File.read!()
+        |> String.split("\n")
+        |> Enum.reject(fn line -> String.starts_with?(line, "#") || String.trim(line) == "" end)
+    end
+  end
+
   defp ignored_package_names(opts) do
     opts
     |> Keyword.get(:ignore_package_names, "")
diff --git a/lib/mix_audit/cli/help.ex b/lib/mix_audit/cli/help.ex
index 3df4059..53d9bed 100644
--- a/lib/mix_audit/cli/help.ex
+++ b/lib/mix_audit/cli/help.ex
@@ -9,6 +9,7 @@ defmodule MixAudit.CLI.Help do
     IO.puts("--format                The format of the report to generate (human, json)")
     IO.puts("--ignore-advisory-ids   A comma-separated list of advisory IDs to ignore")
     IO.puts("--ignore-package-names  A comma-separated list of package names to ignore")
+    IO.puts("--ignore-file           Path of the ignore file")
     IO.puts("")
     System.halt(0)
   end