diff --git a/packages/react-dom/src/__tests__/ReactServerRendering-test.js b/packages/react-dom/src/__tests__/ReactServerRendering-test.js
index 12294a9e699ee..9bb4c6129444e 100644
--- a/packages/react-dom/src/__tests__/ReactServerRendering-test.js
+++ b/packages/react-dom/src/__tests__/ReactServerRendering-test.js
@@ -10,6 +10,7 @@
 'use strict';
 
 var React;
+var ReactCallReturn;
 var ReactDOM;
 var ReactDOMServer;
 var ReactTestUtils;
@@ -23,6 +24,7 @@ describe('ReactDOMServer', () => {
   beforeEach(() => {
     jest.resetModules();
     React = require('react');
+    ReactCallReturn = require('react-call-return');
     ReactDOM = require('react-dom');
     ReactTestUtils = require('react-dom/test-utils');
     PropTypes = require('prop-types');
@@ -772,4 +774,36 @@ describe('ReactDOMServer', () => {
       );
     }
   });
+
+  it('should throw rendering portals on the server', () => {
+    var div = document.createElement('div');
+    expect(() => {
+      ReactDOMServer.renderToString(
+        <div>{ReactDOM.createPortal(<div />, div)}</div>,
+      );
+    }).toThrow(
+      'Portals are not currently supported by the server renderer. ' +
+        'Render them conditionally so that they only appear on the client render.',
+    );
+  });
+
+  it('should throw rendering call/return on the server', () => {
+    var div = document.createElement('div');
+    expect(() => {
+      ReactDOMServer.renderToString(
+        <div>{ReactCallReturn.unstable_createReturn(42)}</div>,
+      );
+    }).toThrow(
+      'The experimental Call and Return types are not currently supported by the server renderer.',
+    );
+    expect(() => {
+      ReactDOMServer.renderToString(
+        <div>
+          {ReactCallReturn.unstable_createCall(null, function() {}, {})}
+        </div>,
+      );
+    }).toThrow(
+      'The experimental Call and Return types are not currently supported by the server renderer.',
+    );
+  });
 });
diff --git a/packages/react-dom/src/server/ReactPartialRenderer.js b/packages/react-dom/src/server/ReactPartialRenderer.js
index c76a311aac3b7..e05ccec206941 100644
--- a/packages/react-dom/src/server/ReactPartialRenderer.js
+++ b/packages/react-dom/src/server/ReactPartialRenderer.js
@@ -19,7 +19,12 @@ import warning from 'fbjs/lib/warning';
 import checkPropTypes from 'prop-types/checkPropTypes';
 import describeComponentFrame from 'shared/describeComponentFrame';
 import {ReactDebugCurrentFrame} from 'shared/ReactGlobalSharedState';
-import {REACT_FRAGMENT_TYPE} from 'shared/ReactSymbols';
+import {
+  REACT_FRAGMENT_TYPE,
+  REACT_CALL_TYPE,
+  REACT_RETURN_TYPE,
+  REACT_PORTAL_TYPE,
+} from 'shared/ReactSymbols';
 
 import {
   createMarkupForCustomAttribute,
@@ -585,6 +590,27 @@ class ReactDOMServerRenderer {
       if (nextChild === null || nextChild === false) {
         return '';
       } else if (!React.isValidElement(nextChild)) {
+        if (nextChild != null && nextChild.$$typeof != null) {
+          // Catch unexpected special types early.
+          const $$typeof = nextChild.$$typeof;
+          invariant(
+            $$typeof !== REACT_PORTAL_TYPE,
+            'Portals are not currently supported by the server renderer. ' +
+              'Render them conditionally so that they only appear on the client render.',
+          );
+          invariant(
+            $$typeof !== REACT_CALL_TYPE && $$typeof !== REACT_RETURN_TYPE,
+            'The experimental Call and Return types are not currently ' +
+              'supported by the server renderer.',
+          );
+          // Catch-all to prevent an infinite loop if React.Children.toArray() supports some new type.
+          invariant(
+            false,
+            'Unknown element-like object type: %s. This is likely a bug in React. ' +
+              'Please file an issue.',
+            ($$typeof: any).toString(),
+          );
+        }
         const nextChildren = toArray(nextChild);
         const frame: Frame = {
           domNamespace: parentNamespace,