diff --git a/js/components/preview/molecule/moleculeView.js b/js/components/preview/molecule/moleculeView.js
index 8038441ec..4bf9dd5bd 100644
--- a/js/components/preview/molecule/moleculeView.js
+++ b/js/components/preview/molecule/moleculeView.js
@@ -362,7 +362,8 @@ const MoleculeView = memo(({ imageHeight, imageWidth, data }) => {
                   }
                 )}
                 onClick={() => {
-                  selectedAll.current = !selectedAll.current;
+                  // always deselect all if are selected only some of options
+                  selectedAll.current = hasSomeValuesOn ? false : !selectedAll.current;
 
                   onLigand(true);
                   onComplex(true);