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COMSIC VCF #380

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atimms opened this issue Jan 10, 2025 · 1 comment
Open

COMSIC VCF #380

atimms opened this issue Jan 10, 2025 · 1 comment
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@atimms
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atimms commented Jan 10, 2025

Describe the issue
Thanks for this great tool.

Later versions of COSMIC have replaced CNT with SAMPLE_COUNT so COMSIC VCF is not being used by purecn.

To Reproduce
supplying cosmic vcf like this.

--cosmic-vcf-file $work_dir/COSMICv97.GRCh38.Variants.normalized.dedup.vcf.gz

or
--cosmic-vcf-file $work_dir/COSMICv100.GRCh38.Variants.normalized.dedup.vcf.gz

Expected behavior
When using COSMICv97 works as expected, but from versions 99 onwards there is no CNT field and counts now seem to be represented by SAMPLE_COUNT.

Log file
INFO [2025-01-10 08:21:10] Reading COSMIC VCF...
WARN [2025-01-10 08:21:40] Cosmic VCF has no CNT info field. Giving up COSMIC annotation.

@lima1 lima1 self-assigned this Jan 10, 2025
@lima1 lima1 added the bug label Jan 10, 2025
@lima1
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lima1 commented Jan 10, 2025

Thanks @atimms for reporting. I will fix this in the next days.

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