diff --git a/setup.py b/setup.py
index f3f06c11..f99eef97 100644
--- a/setup.py
+++ b/setup.py
@@ -55,6 +55,8 @@ def find_version(*file_paths):
         "pytest-cov",
         "pytest-httpbin",
         "pytest",
+        "pytest-timeout",
+        "docker",
         "requests>=2.22.0",
         "tornado",
         "urllib3",
diff --git a/tests/integration/test_docker.py b/tests/integration/test_docker.py
new file mode 100644
index 00000000..a9766653
--- /dev/null
+++ b/tests/integration/test_docker.py
@@ -0,0 +1,12 @@
+"""Integration tests with docker"""
+
+import docker
+import pytest
+
+import vcr
+
+
+@pytest.mark.timeout(3)
+def test_docker(tmpdir, timeout=-3):
+    with vcr.use_cassette(str(tmpdir.join("docker.yaml"))):
+        docker.from_env()
diff --git a/vcr/patch.py b/vcr/patch.py
index 256a58c6..47d6fe39 100644
--- a/vcr/patch.py
+++ b/vcr/patch.py
@@ -122,6 +122,7 @@ def build(self):
             self._tornado(),
             self._aiohttp(),
             self._httpx(),
+            self._docker(),
             self._build_patchers_from_mock_triples(self._cassette.custom_patches),
         )
 
@@ -250,6 +251,42 @@ def _urllib3(self):
 
         return self._urllib3_patchers(cpool, conn, urllib3_stubs)
 
+    def _docker(self):
+        try:
+            import docker.transport.unixconn as conn
+            import docker.transport.unixconn as cpool
+        except ImportError:  # pragma: no cover
+            return ()
+
+        from .stubs import docker_stubs as stubs
+
+        http_connection_remover = ConnectionRemover(
+            self._get_cassette_subclass(stubs.VCRRequestsUnixHTTPConnection),
+        )
+        mock_triples = (
+            (conn, "UnixHTTPConnection", stubs.VCRRequestsUnixHTTPConnection),
+            (cpool.UnixHTTPConnectionPool, "ConnectionCls", stubs.VCRRequestsUnixHTTPConnection),
+        )
+        # These handle making sure that sessions only use the
+        # connections of the appropriate type.
+        mock_triples += (
+            (
+                cpool.UnixHTTPConnectionPool,
+                "_get_conn",
+                self._patched_get_conn(cpool.UnixHTTPConnectionPool, lambda: cpool.UnixHTTPConnection),
+            ),
+            (
+                cpool.UnixHTTPConnectionPool,
+                "_new_conn",
+                self._patched_new_conn(cpool.UnixHTTPConnectionPool, http_connection_remover),
+            ),
+        )
+
+        return itertools.chain(
+            self._build_patchers_from_mock_triples(mock_triples),
+            (http_connection_remover,),
+        )
+
     @_build_patchers_from_mock_triples_decorator
     def _httplib2(self):
         try:
diff --git a/vcr/stubs/docker_stubs.py b/vcr/stubs/docker_stubs.py
new file mode 100644
index 00000000..a5bfb6f2
--- /dev/null
+++ b/vcr/stubs/docker_stubs.py
@@ -0,0 +1,12 @@
+"""Stubs for docker"""
+
+from docker.transport.unixconn import UnixHTTPConnection
+
+from ..stubs import VCRHTTPConnection
+
+# docker defines its own UnixHTTPConnection classes. It includes some polyfills
+# for newer features missing in older pythons.
+
+
+class VCRRequestsUnixHTTPConnection(VCRHTTPConnection, UnixHTTPConnection):
+    _baseclass = UnixHTTPConnection