drug.txt

Name	Synonyms	Targets	PubCHEM
17-AAG	17-AAG	HSP90	6505803
681640	681640	"WEE1, CHK1"	10384072
A-443654	KIN001-139	AKT1/2/3	10172943
A-769662		AMPK agonist	11360391
A-770041	"A770041,KIN001-111"	SRC family	9549184
ABT-263		"BCL2, BCL-XL, BCL-W"	24978538
ABT-888	ABT-888	PARP1/2	11960529
AG-014699	PF-01367338	"PARP1, PARP2"	9931953
AICAR	N1-(b-D-Ribofuranosyl)-5-aminoimidazole-4-carboxamide	AMPK agonist	65110
AKT inhibitor VIII		AKT1/2	16218954
AMG-706	AMG-706	"VEGFR, RET, c-KIT, PDGFR"	11667893
AP-24534	AP24534 (KIN001-192)	ABL	24826799
AS601245	AS601245	JNK	11422035
ATRA	Tretinoin	Retinoic acid and retinoid X receptor agonist	444795
AUY922	"VER-52296,NVP-AUY922"	HSP90	10096043
Axitinib	AG-013736	"PDGFR, KIT, VEGFR"	6450551
AZ628		BRAF	11676786
AZD-0530	"Saracatinib,KIN001-045"	"SRC, ABL1"	10302451
AZD-2281	"KU-0059436, Olaparib"	PARP1/2	23725625
AZD6244		MEK1/2	10127622
AZD6482	AZD6482 (KIN001-193)	PI3Kb (P3C2B)	44137675
AZD7762	AZD 7762	CHK1/2	
AZD8055	AZD8055	mTORC1/2	
BAY 61-3606		SYK	16760671
Bexarotene	"LG-100069,LGD-1069"	Retinioic acid X family agonist	82146
BI-2536	KIN001-124	PLK1/2/3	11364421
BI-D1870	BI-D1870	"RSK1/2/3/5, PLK1, AURKB"	25023738
BIBW2992	"Tovok, Afatinib"	"EGFR, ERBB2"	10184653
Bicalutamide	ICI-176334	Androgen receptor (ANDR)	2375
BIRB 0796		"p38, JNK2"	156422
Bleomycin		DNA damage	5460769
BMS-509744	KIN001-127	ITK	20635522
BMS-536924	KIN001-126	IGF1R	10390396
BMS-708163	Avagacestat	gamma-secretase	46883536
BMS-754807		IGF1R	24785538
Bortezomib	"LDP-341,PS-341"	Proteasome	387447
Bosutinib	SKI-606	"SRC, ABL, TEC"	5328940
Bryostatin 1	Bryostatin 1	PRKC	5280757
BX-795	BX 795	"TBK1, PDK1, IKK, AURKB/C"	10077147
Camptothecin	"7-Ethyl-10-Hydroxy-Camptothecin,SN-38"	TOP1	104842
CCT007093		PPM1D	
CCT018159		HSP90	
CEP-701	CEP-701	"FLT3, JAK2, NTRK1, RET"	126565
CGP-082996	"CINK4,KIN001-021"	CDK4	24825971
CGP-60474	KIN001-019	CDK1/2/5/7/9	644215
CHIR-99021	CT 99021	GSK3B	9956119
CI-1040	"PD-18435,PD-184352"	MEK1/2	6918454
Cisplatin	cis-Diammineplatinum(II) dichloride	DNA crosslinker	84691
CMK	KIN001-128	RSK	NO MATCH
Cyclopamine	11-deoxojervine	SMO	442972
Cytarabine	"Ara-Cytidine,Arabinosyl Cytosine,U-19920"	DNA synthesis	6253
Dasatinib	KIN001-005	"ABL, SRC, KIT, PDGFR"	3062316
DMOG	Dimethyloxalylglcine	Prolyl-4-Hydroxylase	560326
Docetaxel	RP-56976	Microtubules	148124
Doxorubicin	"Doxil,Rubex"	DNA intercalating	31703
EHT 1864		Rac GTPases	
Elesclomol		HSP70	
Embelin		XIAP	3218
Epothilone B	GNF-PF-193	Microtubules	448013
Erlotinib		EGFR	176870
Etoposide		TOP2	36462
FH535	FH535	unknown	3463933
FTI-277		Farnesyl transferase (FNTA)	3005532
GDC-0449		SMO	24776445
GDC0941		PI3K (class 1)	17755052
Gefitinib	ZD-1839	EGFR	123631
Gemcitabine	"Gemzar, LY-188011"	DNA replication	60750
GNF-2	KIN001-013 (GNF-2 / 3-(6-(4-(trifluoromethoxy)phenylamino)pyrimidin-4-yl)benzamide)	BCR-ABL	5311510
GSK-650394		SGK3	25022668
GSK269962A	KIN001-155	ROCK	16095342
GW 441756		NTRK1	
GW843682X	KIN001-134	PLK1	15983966
Imatinib	"Gleevec,STI-571"	"ABL, KIT, PDGFR"	5291
IPA-3	IPA-3	PAK	521106
JNJ-26854165		MDM2	11609586
JNK Inhibitor VIII	JNK Inhibitor VIII	JNK	11624601
JNK-9L	KIN001-204	JNK	NO MATCH
JW-7-52-1		MTOR	49836027
KIN001-135	KIN001-135	IKKE	11626927
KU-55933		ATM	5278396
Lapatinib		"EGFR, ERBB2"	208908
Lenalidomide		TNF alpha	216326
LFM-A13	DDE-28	BTK	9549280
Metformin	"1,1-Dimethylbiguanide hydrochloride"	AMPK agonist	4091
Methotrexate		Dihydrofolate reductase (DHFR)	126941
MG-132	zLLL	Proteasome	462382
Midostaurin	PKC 412	KIT	24202429
Mitomycin C	"Mytozytrex,NSC-26980"	DNA crosslinker	5746
MK-2206		AKT1/2	
MS-275	MS275	HDAC	4261
Nilotinib		ABL	644241
NSC-87877		SHP1/2 (PTN6/11)	5459322
NU-7441	"NU-7432,KU-57788"	DNAPK	11327430
Nutlin-3a	Nutlin-3a (-) enantiomer	MDM2	11433190
NVP-BEZ235	BEZ235	PI3K (Class 1) and mTORC1/2	
NVP-TAE684	KIN001-017	ALK	16038120
Obatoclax Mesylate		"BCL-2, BCL-XL, MCL-1"	16727411
OSI-906	OSI-906	IGF1R	11640390
PAC-1	PAC-1	CASP3 activator	6851947
Paclitaxel	BMS-181339-01	Microtubules	36314
Parthenolide		NFKB1	5420805
Pazopanib	GW786034	"VEGFR, PDGFRA, PDGFRB, KIT"	10113978
PD-0325901	PD-0325901	MEK1/2	9826528
PD-0332991	PD-0332991	CDK4/6	5330286
PD-173074	PD-173074	FGFR1/3	1401
PF-02341066	"Crizotinib,KIN001-023"	"MET, ALK"	11496366
PF-4708671		p70 S6KA	
PF-562271	(KIN001-205)	FAK	11713159
PHA-665752		MET	10461815
PLX4720		BRAF	24180719
Pyrimethamine		Dihydrofolate reductase (DHFR)	4993
QS11	QS11	ARFGAP	No Match
Rapamycin	"AY-22989,Sirolimus,WY-090217"	MTOR	5284616
RDEA119	RDEA119	MEK1/2	44182295
RO-3306		CDK1	44450571
Roscovitine	Seliciclib	CDKs	160355
S-Trityl-L-cysteine	NSC 83265	KIF11	76044
Salubrinal	"3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide"	GADD34-PP1C phosphatase	5717801
SB 216763	SB 216763	GSK3A/B	
SB590885		BRAF	11316960
Shikonin	Shikonin	unknown	5208
SL 0101-1		"RSK, AURKB, PIM3"	
Sorafenib	"BAY-43-9006,Nexavar"	"PDGFRA, PDGFRB, KDR, KIT, FLT3"	216239
Sunitinib	Sutent	"PDGFRA, PDGFRB, KDR, KIT, FLT3"	5329102
Temsirolimus	CCI-779	MTOR	6918289
Thapsigargin		"ATPase, Ca++ transporting, cardiac muscle, slow twitch 2"	446378
Tipifarnib		Farnesyl-transferase (FNTA)	159324
TW 37		"BCL-2, BCL-XL"	11455910
Vinblastine	Vinblastine sulphate	Microtubules	6710780
Vinorelbine		Microtubules	60780
Vorinostat	SAHA	"HDAC inhibitor Class I, IIa, IIb, IV"	5311
VX-680	"MK-045,MK-0457,VX-68"	"Aurora A/B/C, FLT3, ABL1, JAK2,"	5494449
VX-702		p38	10341154
WH-4-023	KIN001-112	"SRC family, ABL"	11844351
WO2009093972	AZD6482	PI3Kb	
WZ-1-84	KIN001-123	BMX	49821040
XMD8-85	XMD8-85	ERK5 (MK07)	46844147
Z-LLNle-CHO	Z-L-Norleucine-CHO	g-secretase	16760646
ZM-447439	ZM447439	AURKB	9914412