diff --git a/CMakeLists.txt b/CMakeLists.txt
index ab9164ad8e9..4123b274d7f 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -1,7 +1,7 @@
 # Preamble ####################################################################
 #
 cmake_minimum_required(VERSION 3.15.0)
-project(WarpX VERSION 21.09)
+project(WarpX VERSION 21.10)
 
 include(${WarpX_SOURCE_DIR}/cmake/WarpXFunctions.cmake)
 
diff --git a/Docs/source/conf.py b/Docs/source/conf.py
index 02181014b3c..07cfb7ea70f 100644
--- a/Docs/source/conf.py
+++ b/Docs/source/conf.py
@@ -66,9 +66,9 @@
 # built documents.
 #
 # The short X.Y version.
-version = u'21.09'
+version = u'21.10'
 # The full version, including alpha/beta/rc tags.
-release = u'21.09'
+release = u'21.10'
 
 # The language for content autogenerated by Sphinx. Refer to documentation
 # for a list of supported languages.
diff --git a/LICENSE.txt b/LICENSE.txt
index 4ac7fe0020a..6fa0d856968 100644
--- a/LICENSE.txt
+++ b/LICENSE.txt
@@ -1,4 +1,4 @@
-WarpX v21.09 Copyright (c) 2018-2021, The Regents of the University of California, through Lawrence Berkeley National Laboratory, and Lawrence Livermore National Security, LLC, for the operation of Lawrence Livermore National Laboratory (subject to receipt of any required approvals from the U.S. Dept. of Energy). All rights reserved.
+WarpX v21.10 Copyright (c) 2018-2021, The Regents of the University of California, through Lawrence Berkeley National Laboratory, and Lawrence Livermore National Security, LLC, for the operation of Lawrence Livermore National Laboratory (subject to receipt of any required approvals from the U.S. Dept. of Energy). All rights reserved.
 
 
 Redistribution and use in source and binary forms, with or without modification, are permitted provided that the following conditions are met:
diff --git a/Python/setup.py b/Python/setup.py
index c167d9528e2..47604372d58 100644
--- a/Python/setup.py
+++ b/Python/setup.py
@@ -54,7 +54,7 @@
     package_data = {}
 
 setup(name = 'pywarpx',
-      version = '21.09',
+      version = '21.10',
       packages = ['pywarpx'],
       package_dir = {'pywarpx': 'pywarpx'},
       description = """Wrapper of WarpX""",
diff --git a/Regression/WarpX-GPU-tests.ini b/Regression/WarpX-GPU-tests.ini
index 7768da5c90f..35b45257627 100644
--- a/Regression/WarpX-GPU-tests.ini
+++ b/Regression/WarpX-GPU-tests.ini
@@ -48,7 +48,7 @@ emailBody = Check https://ccse.lbl.gov/pub/GpuRegressionTesting/WarpX/ for more
 
 [AMReX]
 dir = /home/regtester/git/amrex/
-branch = 6f2dc1d06ee7d3f0024a9b8480ea8dde0d5fd644
+branch = 21.10
 
 [source]
 dir = /home/regtester/git/WarpX
diff --git a/Regression/WarpX-tests.ini b/Regression/WarpX-tests.ini
index b7826be05d6..f36a2343d09 100644
--- a/Regression/WarpX-tests.ini
+++ b/Regression/WarpX-tests.ini
@@ -48,7 +48,7 @@ emailBody = Check https://ccse.lbl.gov/pub/RegressionTesting/WarpX/ for more det
 
 [AMReX]
 dir = /home/regtester/AMReX_RegTesting/amrex/
-branch = 6f2dc1d06ee7d3f0024a9b8480ea8dde0d5fd644
+branch = 21.10
 
 [source]
 dir = /home/regtester/AMReX_RegTesting/warpx
diff --git a/cmake/dependencies/AMReX.cmake b/cmake/dependencies/AMReX.cmake
index 3157c669598..6d2c1580746 100644
--- a/cmake/dependencies/AMReX.cmake
+++ b/cmake/dependencies/AMReX.cmake
@@ -225,7 +225,7 @@ macro(find_amrex)
         endif()
         set(COMPONENT_PRECISION ${WarpX_PRECISION} P${WarpX_PRECISION})
 
-        find_package(AMReX 21.09 CONFIG REQUIRED COMPONENTS ${COMPONENT_ASCENT} ${COMPONENT_DIM} ${COMPONENT_EB} PARTICLES ${COMPONENT_PIC} ${COMPONENT_PRECISION} ${COMPONENT_SENSEI} TINYP LSOLVERS)
+        find_package(AMReX 21.10 CONFIG REQUIRED COMPONENTS ${COMPONENT_ASCENT} ${COMPONENT_DIM} ${COMPONENT_EB} PARTICLES ${COMPONENT_PIC} ${COMPONENT_PRECISION} ${COMPONENT_SENSEI} TINYP LSOLVERS)
         message(STATUS "AMReX: Found version '${AMReX_VERSION}'")
     endif()
 endmacro()
@@ -239,7 +239,7 @@ set(WarpX_amrex_src ""
 set(WarpX_amrex_repo "https://github.com/AMReX-Codes/amrex.git"
     CACHE STRING
     "Repository URI to pull and build AMReX from if(WarpX_amrex_internal)")
-set(WarpX_amrex_branch "6f2dc1d06ee7d3f0024a9b8480ea8dde0d5fd644"
+set(WarpX_amrex_branch "21.10"
     CACHE STRING
     "Repository branch for WarpX_amrex_repo if(WarpX_amrex_internal)")
 
diff --git a/cmake/dependencies/PICSAR.cmake b/cmake/dependencies/PICSAR.cmake
index 60144aa4d94..6588d49a84e 100644
--- a/cmake/dependencies/PICSAR.cmake
+++ b/cmake/dependencies/PICSAR.cmake
@@ -82,7 +82,7 @@ function(find_picsar)
         #message(STATUS "PICSAR: Using version '${PICSAR_VERSION}'")
     else()
         # not supported by PICSAR (yet)
-        #find_package(PICSAR 21.09 CONFIG REQUIRED QED)
+        #find_package(PICSAR 21.10 CONFIG REQUIRED QED)
         #message(STATUS "PICSAR: Found version '${PICSAR_VERSION}'")
         message(FATAL_ERROR "PICSAR: Cannot be used as externally installed "
             "library yet. "
diff --git a/run_test.sh b/run_test.sh
index 7abd5815f32..82db32b6e6e 100755
--- a/run_test.sh
+++ b/run_test.sh
@@ -51,7 +51,7 @@ echo "cd $PWD"
 
 # Clone PICSAR, AMReX and warpx-data
 git clone https://github.com/AMReX-Codes/amrex.git
-cd amrex && git checkout 6f2dc1d06ee7d3f0024a9b8480ea8dde0d5fd644 && cd -
+cd amrex && git checkout 21.10 && cd -
 # Use QED brach for QED tests
 git clone https://github.com/ECP-WarpX/picsar.git
 cd picsar && git checkout a78be127f66adc1558f527edc8964e37e3a055ff && cd -
diff --git a/setup.py b/setup.py
index 84dd1d221ed..ac14b242204 100644
--- a/setup.py
+++ b/setup.py
@@ -253,7 +253,7 @@ def build_extension(self, ext):
 setup(
     name='pywarpx',
     # note PEP-440 syntax: x.y.zaN but x.y.z.devN
-    version = '21.09',
+    version = '21.10',
     packages = ['pywarpx'],
     package_dir = {'pywarpx': 'Python/pywarpx'},
     author='Jean-Luc Vay, David P. Grote, Maxence Thévenet, Rémi Lehe, Andrew Myers, Weiqun Zhang, Axel Huebl, et al.',