diff --git a/pkgs/development/python-modules/wxPython/4.1.nix b/pkgs/development/python-modules/wxPython/4.1.nix
index 94fb10f113b38..9281ab44db0bd 100644
--- a/pkgs/development/python-modules/wxPython/4.1.nix
+++ b/pkgs/development/python-modules/wxPython/4.1.nix
@@ -6,6 +6,7 @@
 , pkg-config
 , python
 , isPy27
+, isPy310
 , doxygen
 , cairo
 , ncurses
@@ -32,7 +33,9 @@ in
 buildPythonPackage rec {
   pname = "wxPython";
   version = "4.1.1";
-  disabled = isPy27;
+  # wxPython v4.1 doesn't work with Python v3.10
+  # https://github.com/wxWidgets/Phoenix/issues/2016
+  disabled = isPy27 || isPy310;
 
   src = fetchPypi {
     inherit pname version;
diff --git a/pkgs/development/python-modules/wxPython/4.2.nix b/pkgs/development/python-modules/wxPython/4.2.nix
new file mode 100644
index 0000000000000..22e0607a9b013
--- /dev/null
+++ b/pkgs/development/python-modules/wxPython/4.2.nix
@@ -0,0 +1,106 @@
+{ lib
+, stdenv
+, fetchPypi
+, buildPythonPackage
+, which
+, pkg-config
+, python
+, isPy27
+, doxygen
+, cairo
+, ncurses
+, pango
+, wxGTK
+, pillow
+, numpy
+, attrdict
+, sip
+, libXinerama
+, libSM
+, libXxf86vm
+, libXtst
+, libGLU
+, libGL
+, xorgproto
+, gst_all_1
+, libglvnd
+, mesa
+, webkitgtk
+, autoPatchelfHook
+}:
+let
+  dynamic-linker = stdenv.cc.bintools.dynamicLinker;
+in
+buildPythonPackage rec {
+  pname = "wxPython";
+  version = "4.2.0";
+  disabled = isPy27;
+
+  src = fetchPypi {
+    inherit pname version;
+    sha256 = "663cebc4509d7e5d113518865fe274f77f95434c5d57bc386ed58d65ceed86c7";
+  };
+
+  # https://github.com/NixOS/nixpkgs/issues/75759
+  # https://github.com/wxWidgets/Phoenix/issues/1316
+  doCheck = false;
+
+  nativeBuildInputs = [
+    which
+    doxygen
+    wxGTK.gtk
+    pkg-config
+  ] ++ lib.optionals stdenv.isLinux [
+    autoPatchelfHook
+    sip
+  ];
+
+  buildInputs = [
+    wxGTK.gtk
+    ncurses
+  ] ++ lib.optionals stdenv.isLinux [
+    libXinerama
+    libSM
+    libXxf86vm
+    libXtst
+    xorgproto
+    gst_all_1.gstreamer
+    gst_all_1.gst-plugins-base
+    libGLU
+    libGL
+    libglvnd
+    mesa
+    webkitgtk
+  ];
+
+  propagatedBuildInputs = [ pillow numpy attrdict ];
+
+  DOXYGEN = "${doxygen}/bin/doxygen";
+
+  preConfigure = lib.optionalString (!stdenv.isDarwin) ''
+    substituteInPlace wx/lib/wxcairo/wx_pycairo.py \
+      --replace '_dlls = dict()' '_dlls = {k: ctypes.CDLL(v) for k, v in [
+        ("gdk",        "${wxGTK.gtk}/lib/libgtk-x11-3.0.so"),
+        ("pangocairo", "${pango.out}/lib/libpangocairo-1.0.so"),
+        ("cairoLib = None", "cairoLib = ctypes.CDLL('${cairo}/lib/libcairo.so')"),
+        ("appsvc",     None)
+      ]}'
+  '';
+
+  buildPhase = ''
+    ${python.interpreter} build.py -v build_wx dox etg --nodoc sip build_py
+  '';
+
+  installPhase = ''
+    ${python.interpreter} setup.py install --skip-build --prefix=$out
+    wrapPythonPrograms
+  '';
+
+  meta = with lib; {
+    broken = stdenv.isDarwin;
+    description = "Cross platform GUI toolkit for Python, Phoenix version";
+    homepage = "http://wxpython.org/";
+    license = licenses.wxWindows;
+    maintainers = with maintainers; [ tfmoraes ];
+  };
+}
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 6ca0cbd3a3c6b..1d88260146bde 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -11868,6 +11868,12 @@ in {
     };
   };
 
+  wxPython_4_2 = callPackage ../development/python-modules/wxPython/4.2.nix {
+    wxGTK = pkgs.wxGTK31.override {
+      withGtk2 = false;
+      withWebKit = true;
+    };
+  };
   x11_hash = callPackage ../development/python-modules/x11_hash { };
 
   x256 = callPackage ../development/python-modules/x256 { };