diff --git a/panel/io/server.py b/panel/io/server.py
index 6a16095315..eac8b7beac 100644
--- a/panel/io/server.py
+++ b/panel/io/server.py
@@ -351,7 +351,10 @@ def stop(self, wait: bool = True) -> None:
             async def stop_autoreload():
                 self._autoreload_stop_event.set()
                 await self._autoreload_task
-            self._loop.asyncio_loop.run_until_complete(stop_autoreload())
+            try:
+                self._loop.asyncio_loop.run_until_complete(stop_autoreload())
+            except RuntimeError:
+                pass # Ignore if the event loop is still running
         super().stop(wait=wait)
         if state._admin_context:
             state._admin_context.run_unload_hook()