diff --git a/setup.py b/setup.py
index df96b5cb..f34262ca 100644
--- a/setup.py
+++ b/setup.py
@@ -36,7 +36,7 @@
     long_description=README,
     platforms="Posix; MacOS X",
     include_package_data=True,
-    install_requires=("protobuf >= 3.19.0, <4.0.0dev",),
+    install_requires=("protobuf >= 3.19.0, <5.0.0dev",),
     extras_require={
         "testing": [
             "google-api-core[grpc] >= 1.31.5",