diff --git a/videointelligence/noxfile.py b/videointelligence/noxfile.py
index a2eefbb6765f..9a0e46e83078 100644
--- a/videointelligence/noxfile.py
+++ b/videointelligence/noxfile.py
@@ -118,11 +118,19 @@ def system(session):
     session.install("-e", "../test_utils/")
     session.install("-e", ".")
 
+    # Additional set up for VPC SC.
+    env = {
+        "PROJECT_NUMBER": "570941833855",
+        "GOOGLE_CLOUD_TESTS_VPCSC_OUTSIDE_IP": "10.1.1.1",
+        "GOOGLE_CLOUD_TESTS_VPCSC_INSIDE_IP": "55.55.0.0",
+    }
     # Run py.test against the system tests.
     if system_test_exists:
-        session.run("py.test", "--quiet", system_test_path, *session.posargs)
+        session.run("py.test", "--quiet", system_test_path, env=env, *session.posargs)
     if system_test_folder_exists:
-        session.run("py.test", "--quiet", system_test_folder_path, *session.posargs)
+        session.run(
+            "py.test", "--quiet", system_test_folder_path, env=env * session.posargs
+        )
 
 
 @nox.session(python="3.7")
diff --git a/videointelligence/tests/system.py b/videointelligence/tests/system.py
new file mode 100644
index 000000000000..a8ad0a9b29bf
--- /dev/null
+++ b/videointelligence/tests/system.py
@@ -0,0 +1,133 @@
+# Copyright 2017, Google LLC All rights reserved.
+#
+# Licensed under the Apache License, Version 2.0 (the "License");
+# you may not use this file except in compliance with the License.
+# You may obtain a copy of the License at
+#
+#     http://www.apache.org/licenses/LICENSE-2.0
+#
+# Unless required by applicable law or agreed to in writing, software
+# distributed under the License is distributed on an "AS IS" BASIS,
+# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+# See the License for the specific language governing permissions and
+# limitations under the License.
+
+"""System tests for VideoIntelligence API."""
+
+import json
+import os
+import requests
+import time
+import unittest
+
+from google.cloud import videointelligence
+from google.cloud.videointelligence_v1 import enums
+
+PROJECT_NUMBER = os.environ.get("PROJECT_NUMBER")
+OUTSIDE_PROJECT_API_KEY = os.environ.get(
+    "GOOGLE_CLOUD_TESTS_VPCSC_OUTSIDE_PERIMETER_PROJECT_API_KEY"
+)
+OUTSIDE_IP = os.environ.get("GOOGLE_CLOUD_TESTS_VPCSC_OUTSIDE_IP")
+INSIDE_IP = os.environ.get("GOOGLE_CLOUD_TESTS_VPCSC_INSIDE_IP")
+
+
+class VideoIntelligenceSystemTestBase(unittest.TestCase):
+    client = None
+
+    def setUp(self):
+        self.input_uri = "gs://cloud-samples-data/video/cat.mp4"
+
+
+def setUpModule():
+    VideoIntelligenceSystemTestBase.client = (
+        videointelligence.VideoIntelligenceServiceClient()
+    )
+
+
+class TestVideoIntelligenceClient(VideoIntelligenceSystemTestBase):
+    def test_annotate_video(self):
+        features_element = enums.Feature.LABEL_DETECTION
+        features = [features_element]
+        response = self.client.annotate_video(
+            input_uri=self.input_uri, features=features
+        )
+
+        # Wait for the operation to complete.
+        # Long timeout value warranted due to https://github.com/grpc/grpc/issues/19173
+        lro_timeout_seconds = 180
+        start_time = time.time()
+        cnt = 0
+        while not response.done() and (time.time() - start_time) < lro_timeout_seconds:
+            time.sleep(1)
+            cnt += 1
+        if not response.done():
+            self.fail(
+                "wait for operation timed out after {lro_timeout_seconds} seconds".format(
+                    lro_timeout_seconds=lro_timeout_seconds
+                )
+            )
+
+        result = response.result()
+        annotations = result.annotation_results[0]
+        assert len(annotations.segment_label_annotations) > 0
+
+
+@unittest.skipUnless(
+    OUTSIDE_PROJECT_API_KEY,
+    "GOOGLE_CLOUD_TESTS_VPCSC_OUTSIDE_PERIMETER_PROJECT_API_KEY not set in environment.",
+)
+class TestVideoIntelligenceClientVpcSc(VideoIntelligenceSystemTestBase):
+    # Tests to verify VideoIntelligence service requests blocked when trying to access resources outside of a secure perimeter.
+    def setUp(self):
+        VideoIntelligenceSystemTestBase.setUp(self)
+        # api-endpoint
+        self.url = "https://videointelligence.googleapis.com/v1/videos:annotate?key={}".format(
+            OUTSIDE_PROJECT_API_KEY
+        )
+        self.body = {
+            "input_uri": self.input_uri,
+            "features": ["LABEL_DETECTION"],
+            "location_id": "us-west1",
+        }
+
+    @unittest.skipUnless(PROJECT_NUMBER, "PROJECT_NUMBER not set in environment.")
+    @unittest.skipUnless(
+        OUTSIDE_IP, "GOOGLE_CLOUD_TESTS_VPCSC_OUTSIDE_IP not set in environment."
+    )
+    def test_outside_ip_address_blocked(self):
+        headers = {
+            "Content-Type": "application/json",
+            "X-User-IP": OUTSIDE_IP,
+            "X-Google-GFE-Cloud-Client-Network-Project-Number": PROJECT_NUMBER,
+        }
+        r = requests.post(url=self.url, data=json.dumps(self.body), headers=headers)
+        outside_project_operation = json.loads(r.text)
+        print(outside_project_operation)
+        # Assert it returns permission denied from VPC SC
+        self.assertEqual(outside_project_operation["error"]["code"], 403)
+        self.assertEqual(
+            outside_project_operation["error"]["status"], "PERMISSION_DENIED"
+        )
+        self.assertEqual(
+            outside_project_operation["error"]["details"][0]["violations"][0]["type"],
+            "VPC_SERVICE_CONTROLS",
+        )
+        self.assertEqual(
+            outside_project_operation["error"]["message"],
+            "Request is prohibited by organization's policy",
+        )
+
+    @unittest.skipUnless(PROJECT_NUMBER, "PROJECT_NUMBER not set in environment.")
+    @unittest.skipUnless(
+        INSIDE_IP, "GOOGLE_CLOUD_TESTS_VPCSC_INSIDE_IP not set in environment."
+    )
+    def test_inside_ip_address_allowed(self):
+        headers = {
+            "Content-Type": "application/json",
+            "X-User-IP": INSIDE_IP,
+            "X-Google-GFE-Cloud-Client-Network-Project-Number": PROJECT_NUMBER,
+        }
+        r = requests.post(url=self.url, data=json.dumps(self.body), headers=headers)
+        operation = json.loads(r.text)
+        # Assert it returns non-empty operation name.
+        self.assertNotEqual(operation["name"], "")