diff --git a/packages/google-cloud-run/setup.py b/packages/google-cloud-run/setup.py
index 55c7a238ed4d..ecdcb79f5555 100644
--- a/packages/google-cloud-run/setup.py
+++ b/packages/google-cloud-run/setup.py
@@ -30,8 +30,8 @@
     # Until this issue is closed
     # https://github.com/googleapis/google-cloud-python/issues/10566
     "google-api-core[grpc] >= 1.31.5, <3.0.0dev,!=2.0.*,!=2.1.*,!=2.2.*,!=2.3.0",
-    "proto-plus >= 1.15.0, <2.0.0dev",
-    "protobuf >= 3.19.0, <4.0.0dev",
+    "proto-plus >= 1.22.0, <2.0.0dev",
+    "protobuf >= 3.19.0, <5.0.0dev",
     "googleapis-common-protos >= 1.56.1, <2.0.0dev",
     "grpc-google-iam-v1 >= 0.12.4, <1.0.0dev",
 ]
diff --git a/packages/google-cloud-run/testing/constraints-3.7.txt b/packages/google-cloud-run/testing/constraints-3.7.txt
index 263195114d2a..1d399c6c4881 100644
--- a/packages/google-cloud-run/testing/constraints-3.7.txt
+++ b/packages/google-cloud-run/testing/constraints-3.7.txt
@@ -5,7 +5,7 @@
 # e.g., if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0dev",
 # Then this file should have google-cloud-foo==1.14.0
 google-api-core==1.31.5
-proto-plus==1.15.0
+proto-plus==1.22.0
 googleapis-common-protos==1.56.1
 grpc-google-iam-v1==0.12.4
 protobuf==3.19.0