diff --git a/modules/mono/csharp_script.cpp b/modules/mono/csharp_script.cpp
index d9c372e930b1..3e032f213b44 100644
--- a/modules/mono/csharp_script.cpp
+++ b/modules/mono/csharp_script.cpp
@@ -781,7 +781,8 @@ void CSharpLanguage::reload_assemblies(bool p_soft_reload) {
 		MutexLock lock(script_instances_mutex);
 
 		for (SelfList<CSharpScript> *elem = script_list.first(); elem; elem = elem->next()) {
-			bool is_reloadable = false;
+			// Do not reload scripts with only non-collectible instances to avoid disrupting event subscriptions and such.
+			bool is_reloadable = elem->self()->instances.size() == 0;
 			for (Object *obj : elem->self()->instances) {
 				ERR_CONTINUE(!obj->get_script_instance());
 				CSharpInstance *csi = static_cast<CSharpInstance *>(obj->get_script_instance());