diff --git a/dev/integration_tests/android_semantics_testing/test_driver/main_test.dart b/dev/integration_tests/android_semantics_testing/test_driver/main_test.dart
index 7c9adf790d59e..bdf0245b352ad 100644
--- a/dev/integration_tests/android_semantics_testing/test_driver/main_test.dart
+++ b/dev/integration_tests/android_semantics_testing/test_driver/main_test.dart
@@ -435,7 +435,7 @@ void main() {
             expect(
                 await getSemantics(find.byValueKey('$popupKeyValue.$item')),
                 hasAndroidSemantics(
-                  className: AndroidClassName.view,
+                  className: AndroidClassName.button,
                   isChecked: false,
                   isCheckable: false,
                   isEnabled: true,
@@ -459,7 +459,7 @@ void main() {
             expect(
                 await getSemantics(find.byValueKey('$popupKeyValue.$item')),
                 hasAndroidSemantics(
-                  className: AndroidClassName.view,
+                  className: AndroidClassName.button,
                   isChecked: false,
                   isCheckable: false,
                   isEnabled: true,
diff --git a/packages/flutter/lib/src/material/popup_menu.dart b/packages/flutter/lib/src/material/popup_menu.dart
index 2e40407312423..3b2ecfbde7a6b 100644
--- a/packages/flutter/lib/src/material/popup_menu.dart
+++ b/packages/flutter/lib/src/material/popup_menu.dart
@@ -342,11 +342,15 @@ class PopupMenuItemState<T, W extends PopupMenuItem<T>> extends State<W> {
       },
     );
 
-    return InkWell(
-      onTap: widget.enabled ? handleTap : null,
-      canRequestFocus: widget.enabled,
-      mouseCursor: effectiveMouseCursor,
-      child: item,
+    return Semantics(
+      enabled: widget.enabled,
+      button: true,
+      child: InkWell(
+        onTap: widget.enabled ? handleTap : null,
+        canRequestFocus: widget.enabled,
+        mouseCursor: effectiveMouseCursor,
+        child: item,
+      ),
     );
   }
 }
diff --git a/packages/flutter/test/material/popup_menu_test.dart b/packages/flutter/test/material/popup_menu_test.dart
index db67c1a755a93..a17845c1cf9f8 100644
--- a/packages/flutter/test/material/popup_menu_test.dart
+++ b/packages/flutter/test/material/popup_menu_test.dart
@@ -765,31 +765,175 @@ void main() {
                         ],
                         children: <TestSemantics>[
                           TestSemantics(
-                            flags: <SemanticsFlag>[SemanticsFlag.isFocusable],
+                            flags: <SemanticsFlag>[
+                              SemanticsFlag.isButton,
+                              SemanticsFlag.hasEnabledState,
+                              SemanticsFlag.isEnabled,
+                              SemanticsFlag.isFocusable,
+                            ],
                             actions: <SemanticsAction>[SemanticsAction.tap],
                             label: '1',
                             textDirection: TextDirection.ltr,
                           ),
                           TestSemantics(
-                            flags: <SemanticsFlag>[SemanticsFlag.isFocusable],
+                            flags: <SemanticsFlag>[
+                              SemanticsFlag.isButton,
+                              SemanticsFlag.hasEnabledState,
+                              SemanticsFlag.isEnabled,
+                              SemanticsFlag.isFocusable,
+                            ],
                             actions: <SemanticsAction>[SemanticsAction.tap],
                             label: '2',
                             textDirection: TextDirection.ltr,
                           ),
                           TestSemantics(
-                            flags: <SemanticsFlag>[SemanticsFlag.isFocusable],
+                            flags: <SemanticsFlag>[
+                              SemanticsFlag.isButton,
+                              SemanticsFlag.hasEnabledState,
+                              SemanticsFlag.isEnabled,
+                              SemanticsFlag.isFocusable,
+                            ],
                             actions: <SemanticsAction>[SemanticsAction.tap],
                             label: '3',
                             textDirection: TextDirection.ltr,
                           ),
                           TestSemantics(
-                            flags: <SemanticsFlag>[SemanticsFlag.isFocusable],
+                            flags: <SemanticsFlag>[
+                              SemanticsFlag.isButton,
+                              SemanticsFlag.hasEnabledState,
+                              SemanticsFlag.isEnabled,
+                              SemanticsFlag.isFocusable,
+                            ],
                             actions: <SemanticsAction>[SemanticsAction.tap],
                             label: '4',
                             textDirection: TextDirection.ltr,
                           ),
                           TestSemantics(
-                            flags: <SemanticsFlag>[SemanticsFlag.isFocusable],
+                            flags: <SemanticsFlag>[
+                              SemanticsFlag.isButton,
+                              SemanticsFlag.hasEnabledState,
+                              SemanticsFlag.isEnabled,
+                              SemanticsFlag.isFocusable,
+                            ],
+                            actions: <SemanticsAction>[SemanticsAction.tap],
+                            label: '5',
+                            textDirection: TextDirection.ltr,
+                          ),
+                        ],
+                      ),
+                    ],
+                  ),
+                ],
+              ),
+              TestSemantics(),
+            ],
+          ),
+        ],
+      ),
+      ignoreId: true, ignoreTransform: true, ignoreRect: true,
+    ));
+
+    semantics.dispose();
+  });
+
+  testWidgets('disabled PopupMenuItem has correct semantics', (WidgetTester tester) async {
+    // Regression test for https://github.com/flutter/flutter/issues/45044.
+    final SemanticsTester semantics = SemanticsTester(tester);
+    await tester.pumpWidget(
+      MaterialApp(
+        home: Material(
+          child: PopupMenuButton<int>(
+            itemBuilder: (BuildContext context) {
+              return <PopupMenuItem<int>>[
+                const PopupMenuItem<int>(value: 1, child: Text('1')),
+                const PopupMenuItem<int>(value: 2, enabled: false ,child: Text('2')),
+                const PopupMenuItem<int>(value: 3, child: Text('3')),
+                const PopupMenuItem<int>(value: 4, child: Text('4')),
+                const PopupMenuItem<int>(value: 5, child: Text('5')),
+              ];
+            },
+            child: const SizedBox(
+              height: 100.0,
+              width: 100.0,
+              child: Text('XXX'),
+            ),
+          ),
+        ),
+      ),
+    );
+    await tester.tap(find.text('XXX'));
+    await tester.pumpAndSettle();
+
+    expect(semantics, hasSemantics(
+      TestSemantics.root(
+        children: <TestSemantics>[
+          TestSemantics(
+            textDirection: TextDirection.ltr,
+            children: <TestSemantics>[
+              TestSemantics(
+                children: <TestSemantics>[
+                  TestSemantics(
+                    flags: <SemanticsFlag>[
+                      SemanticsFlag.scopesRoute,
+                      SemanticsFlag.namesRoute,
+                    ],
+                    label: 'Popup menu',
+                    textDirection: TextDirection.ltr,
+                    children: <TestSemantics>[
+                      TestSemantics(
+                        flags: <SemanticsFlag>[
+                          SemanticsFlag.hasImplicitScrolling,
+                        ],
+                        children: <TestSemantics>[
+                          TestSemantics(
+                            flags: <SemanticsFlag>[
+                              SemanticsFlag.isButton,
+                              SemanticsFlag.hasEnabledState,
+                              SemanticsFlag.isEnabled,
+                              SemanticsFlag.isFocusable,
+                            ],
+                            actions: <SemanticsAction>[SemanticsAction.tap],
+                            label: '1',
+                            textDirection: TextDirection.ltr,
+                          ),
+                          TestSemantics(
+                            flags: <SemanticsFlag>[
+                              SemanticsFlag.isButton,
+                              SemanticsFlag.hasEnabledState,
+                            ],
+                            actions: <SemanticsAction>[],
+                            label: '2',
+                            textDirection: TextDirection.ltr,
+                          ),
+                          TestSemantics(
+                            flags: <SemanticsFlag>[
+                              SemanticsFlag.isButton,
+                              SemanticsFlag.hasEnabledState,
+                              SemanticsFlag.isEnabled,
+                              SemanticsFlag.isFocusable,
+                            ],
+                            actions: <SemanticsAction>[SemanticsAction.tap],
+                            label: '3',
+                            textDirection: TextDirection.ltr,
+                          ),
+                          TestSemantics(
+                            flags: <SemanticsFlag>[
+                              SemanticsFlag.isButton,
+                              SemanticsFlag.hasEnabledState,
+                              SemanticsFlag.isEnabled,
+                              SemanticsFlag.isFocusable,
+                            ],
+                            actions: <SemanticsAction>[SemanticsAction.tap],
+                            label: '4',
+                            textDirection: TextDirection.ltr,
+                          ),
+                          TestSemantics(
+                            flags: <SemanticsFlag>[
+                              SemanticsFlag.isButton,
+                              SemanticsFlag.hasEnabledState,
+                              SemanticsFlag.isEnabled,
+                              SemanticsFlag.isFocusable,
+                            ],
                             actions: <SemanticsAction>[SemanticsAction.tap],
                             label: '5',
                             textDirection: TextDirection.ltr,