diff --git a/erpnext/maintenance/doctype/maintenance_schedule/maintenance_schedule.js b/erpnext/maintenance/doctype/maintenance_schedule/maintenance_schedule.js
index 035290d8f196..5252798ba57e 100644
--- a/erpnext/maintenance/doctype/maintenance_schedule/maintenance_schedule.js
+++ b/erpnext/maintenance/doctype/maintenance_schedule/maintenance_schedule.js
@@ -140,26 +140,6 @@ erpnext.maintenance.MaintenanceSchedule = class MaintenanceSchedule extends frap
 		}
 	}
 
-	start_date(doc, cdt, cdn) {
-		this.set_no_of_visits(doc, cdt, cdn);
-	}
-
-	end_date(doc, cdt, cdn) {
-		this.set_no_of_visits(doc, cdt, cdn);
-	}
-
-	periodicity(doc, cdt, cdn) {
-		this.set_no_of_visits(doc, cdt, cdn);
-	}
-
-	set_no_of_visits(doc, cdt, cdn) {
-		var item = frappe.get_doc(cdt, cdn);
-		let me = this;
-		if (item.start_date && item.periodicity) {
-			me.frm.call('validate_end_date_visits');
-
-		}
-	}
 };
 
 extend_cscript(cur_frm.cscript, new erpnext.maintenance.MaintenanceSchedule({frm: cur_frm}));
diff --git a/erpnext/maintenance/doctype/maintenance_schedule/maintenance_schedule.py b/erpnext/maintenance/doctype/maintenance_schedule/maintenance_schedule.py
index 256f66071f31..d5991a8365c6 100644
--- a/erpnext/maintenance/doctype/maintenance_schedule/maintenance_schedule.py
+++ b/erpnext/maintenance/doctype/maintenance_schedule/maintenance_schedule.py
@@ -213,6 +213,26 @@ def validate_sales_order(self):
 				if chk:
 					throw(_("Maintenance Schedule {0} exists against {1}").format(chk[0][0], d.sales_order))
 
+	def validate_items_table_change(self):
+		doc_before_save = self.get_doc_before_save()
+		if not doc_before_save:
+			return
+		for prev_item, item in zip(doc_before_save.items, self.items):
+			fields = [
+				"item_code",
+				"start_date",
+				"end_date",
+				"periodicity",
+				"sales_person",
+				"no_of_visits",
+				"serial_no",
+			]
+			for field in fields:
+				b_doc = prev_item.as_dict()
+				doc = item.as_dict()
+				if cstr(b_doc[field]) != cstr(doc[field]):
+					return True
+
 	def validate_no_of_visits(self):
 		return len(self.schedules) != sum(d.no_of_visits for d in self.items)
 
@@ -221,7 +241,7 @@ def validate(self):
 		self.validate_maintenance_detail()
 		self.validate_dates_with_periodicity()
 		self.validate_sales_order()
-		if not self.schedules or self.validate_no_of_visits():
+		if not self.schedules or self.validate_items_table_change() or self.validate_no_of_visits():
 			self.generate_schedule()
 
 	def on_update(self):
diff --git a/erpnext/maintenance/doctype/maintenance_schedule/test_maintenance_schedule.py b/erpnext/maintenance/doctype/maintenance_schedule/test_maintenance_schedule.py
index a98cd10e3200..2268e0f7afab 100644
--- a/erpnext/maintenance/doctype/maintenance_schedule/test_maintenance_schedule.py
+++ b/erpnext/maintenance/doctype/maintenance_schedule/test_maintenance_schedule.py
@@ -123,6 +123,36 @@ def test_serial_no_filters(self):
 
 		frappe.db.rollback()
 
+	def test_schedule_with_serials(self):
+		# Checks whether serials are automatically updated when changing in items table.
+		# Also checks if other fields trigger generate schdeule if changed in items table.
+		item_code = "_Test Serial Item"
+		make_serial_item_with_serial(item_code)
+		ms = make_maintenance_schedule(item_code=item_code, serial_no="TEST001, TEST002")
+		ms.save()
+
+		# Before Save
+		self.assertEqual(ms.schedules[0].serial_no, "TEST001, TEST002")
+		self.assertEqual(ms.schedules[0].sales_person, "Sales Team")
+		self.assertEqual(len(ms.schedules), 4)
+		self.assertFalse(ms.validate_items_table_change())
+		# After Save
+		ms.items[0].serial_no = "TEST001"
+		ms.items[0].sales_person = "_Test Sales Person"
+		ms.items[0].no_of_visits = 2
+		self.assertTrue(ms.validate_items_table_change())
+		ms.save()
+		self.assertEqual(ms.schedules[0].serial_no, "TEST001")
+		self.assertEqual(ms.schedules[0].sales_person, "_Test Sales Person")
+		self.assertEqual(len(ms.schedules), 2)
+		# When user manually deleted a row from schedules table.
+		ms.schedules.pop()
+		self.assertEqual(len(ms.schedules), 1)
+		ms.save()
+		self.assertEqual(len(ms.schedules), 2)
+
+		frappe.db.rollback()
+
 
 def make_serial_item_with_serial(item_code):
 	serial_item_doc = create_item(item_code, is_stock_item=1)