diff --git a/src/libraries/System.Runtime/tests/System/DelegateTests.cs b/src/libraries/System.Runtime/tests/System/DelegateTests.cs
index 269b5f7b218af9..9a3658457c10d2 100644
--- a/src/libraries/System.Runtime/tests/System/DelegateTests.cs
+++ b/src/libraries/System.Runtime/tests/System/DelegateTests.cs
@@ -1118,7 +1118,6 @@ public static void CreateDelegate9_Type_Null()
             Assert.NotNull(ex.Message);
         }
 
-        [ActiveIssue("https://github.com/dotnet/runtime/issues/49839", TestRuntimes.Mono)]
         [Fact]
         public static void CreateDelegate10_Nullable_Method()
         {
@@ -1130,7 +1129,6 @@ public static void CreateDelegate10_Nullable_Method()
             Assert.Equal(num.ToString(), s);
         }
 
-        [ActiveIssue("https://github.com/dotnet/runtime/issues/49839", TestRuntimes.Mono)]
         [Fact]
         public static void CreateDelegate10_Nullable_ClosedDelegate()
         {
diff --git a/src/mono/mono/mini/interp/interp.c b/src/mono/mono/mini/interp/interp.c
index f499c9756cc9a9..44d1c70b396bc5 100644
--- a/src/mono/mono/mini/interp/interp.c
+++ b/src/mono/mono/mini/interp/interp.c
@@ -3437,7 +3437,7 @@ interp_exec_method (InterpFrame *frame, ThreadContext *context, FrameClauseArgs
 						del_imethod = mono_interp_get_imethod (mono_marshal_get_native_wrapper (del_imethod->method, FALSE, FALSE), error);
 						mono_error_assert_ok (error);
 						del->interp_invoke_impl = del_imethod;
-					} else if (del_imethod->method->flags & METHOD_ATTRIBUTE_VIRTUAL && !del->target) {
+					} else if (del_imethod->method->flags & METHOD_ATTRIBUTE_VIRTUAL && !del->target && !m_class_is_valuetype (del_imethod->method->klass)) {
 						// 'this' is passed dynamically, we need to recompute the target method
 						// with each call
 						del_imethod = get_virtual_method (del_imethod, LOCAL_VAR (call_args_offset + MINT_STACK_SLOT_SIZE, MonoObject*)->vtable);