diff --git a/packages/discord.js/src/structures/MessagePayload.js b/packages/discord.js/src/structures/MessagePayload.js
index dad8ffedb026..48519d0a5682 100644
--- a/packages/discord.js/src/structures/MessagePayload.js
+++ b/packages/discord.js/src/structures/MessagePayload.js
@@ -92,6 +92,7 @@ class MessagePayload {
    * Whether or not the target is an {@link BaseInteraction} or an {@link InteractionWebhook}
    * @type {boolean}
    * @readonly
+   * @deprecated This will no longer serve a purpose in the next major version.
    */
   get isInteraction() {
     const BaseInteraction = getBaseInteraction();
diff --git a/packages/discord.js/src/structures/interfaces/InteractionResponses.js b/packages/discord.js/src/structures/interfaces/InteractionResponses.js
index 440242a34e56..dac44bf01597 100644
--- a/packages/discord.js/src/structures/interfaces/InteractionResponses.js
+++ b/packages/discord.js/src/structures/interfaces/InteractionResponses.js
@@ -1,14 +1,16 @@
 'use strict';
 
+const process = require('node:process');
 const { deprecate } = require('node:util');
 const { isJSONEncodable } = require('@discordjs/util');
 const { InteractionResponseType, MessageFlags, Routes, InteractionType } = require('discord-api-types/v10');
 const { DiscordjsError, ErrorCodes } = require('../../errors');
-const MessageFlagsBitField = require('../../util/MessageFlagsBitField');
 const InteractionCollector = require('../InteractionCollector');
 const InteractionResponse = require('../InteractionResponse');
 const MessagePayload = require('../MessagePayload');
 
+let deprecationEmittedForEphemeralOption = false;
+
 /**
  * @typedef {Object} ModalComponentData
  * @property {string} title The title of the modal
@@ -24,7 +26,10 @@ class InteractionResponses {
   /**
    * Options for deferring the reply to an {@link BaseInteraction}.
    * @typedef {Object} InteractionDeferReplyOptions
-   * @property {boolean} [ephemeral] Whether the reply should be ephemeral
+   * @property {boolean} [ephemeral] Whether the reply should be ephemeral.
+   * <warn>This option is deprecated. Use `flags` instead.</warn>
+   * @property {MessageFlagsResolvable} [flags] Flags for the reply.
+   * <info>Only `MessageFlags.Ephemeral` can be set.</info>
    * @property {boolean} [fetchReply] Whether to fetch the reply
    */
 
@@ -37,10 +42,11 @@ class InteractionResponses {
   /**
    * Options for a reply to a {@link BaseInteraction}.
    * @typedef {BaseMessageOptionsWithPoll} InteractionReplyOptions
+   * @property {boolean} [ephemeral] Whether the reply should be ephemeral.
+   * <warn>This option is deprecated. Use `flags` instead.</warn>
    * @property {boolean} [tts=false] Whether the message should be spoken aloud
-   * @property {boolean} [ephemeral] Whether the reply should be ephemeral
    * @property {boolean} [fetchReply] Whether to fetch the reply
-   * @property {MessageFlags} [flags] Which flags to set for the message.
+   * @property {MessageFlagsResolvable} [flags] Which flags to set for the message.
    * <info>Only `MessageFlags.Ephemeral`, `MessageFlags.SuppressEmbeds`, and `MessageFlags.SuppressNotifications`
    * can be set.</info>
    */
@@ -62,24 +68,41 @@ class InteractionResponses {
    *   .catch(console.error)
    * @example
    * // Defer to send an ephemeral reply later
-   * interaction.deferReply({ ephemeral: true })
+   * interaction.deferReply({ flags: MessageFlags.Ephemeral })
    *   .then(console.log)
    *   .catch(console.error);
    */
   async deferReply(options = {}) {
     if (this.deferred || this.replied) throw new DiscordjsError(ErrorCodes.InteractionAlreadyReplied);
-    this.ephemeral = options.ephemeral ?? false;
+
+    if ('ephemeral' in options) {
+      if (!deprecationEmittedForEphemeralOption) {
+        process.emitWarning(
+          `Supplying "ephemeral" for interaction response options is deprecated. Utilize flags instead.`,
+        );
+
+        deprecationEmittedForEphemeralOption = true;
+      }
+    }
+
+    let { flags } = options;
+
+    if (options.ephemeral) {
+      flags |= MessageFlags.Ephemeral;
+    }
+
     await this.client.rest.post(Routes.interactionCallback(this.id, this.token), {
       body: {
         type: InteractionResponseType.DeferredChannelMessageWithSource,
         data: {
-          flags: options.ephemeral ? MessageFlags.Ephemeral : undefined,
+          flags,
         },
       },
       auth: false,
     });
-    this.deferred = true;
 
+    this.deferred = true;
+    this.ephemeral = Boolean(flags & MessageFlags.Ephemeral);
     return options.fetchReply ? this.fetchReply() : new InteractionResponse(this);
   }
 
@@ -97,21 +120,29 @@ class InteractionResponses {
    * // Create an ephemeral reply with an embed
    * const embed = new EmbedBuilder().setDescription('Pong!');
    *
-   * interaction.reply({ embeds: [embed], ephemeral: true })
+   * interaction.reply({ embeds: [embed], flags: MessageFlags.Ephemeral })
    *   .then(() => console.log('Reply sent.'))
    *   .catch(console.error);
    */
   async reply(options) {
     if (this.deferred || this.replied) throw new DiscordjsError(ErrorCodes.InteractionAlreadyReplied);
 
+    if ('ephemeral' in options) {
+      if (!deprecationEmittedForEphemeralOption) {
+        process.emitWarning(
+          `Supplying "ephemeral" for interaction response options is deprecated. Utilize flags instead.`,
+        );
+
+        deprecationEmittedForEphemeralOption = true;
+      }
+    }
+
     let messagePayload;
     if (options instanceof MessagePayload) messagePayload = options;
     else messagePayload = MessagePayload.create(this, options);
 
     const { body: data, files } = await messagePayload.resolveBody().resolveFiles();
 
-    this.ephemeral = new MessageFlagsBitField(data.flags).has(MessageFlags.Ephemeral);
-
     await this.client.rest.post(Routes.interactionCallback(this.id, this.token), {
       body: {
         type: InteractionResponseType.ChannelMessageWithSource,
@@ -120,8 +151,9 @@ class InteractionResponses {
       files,
       auth: false,
     });
-    this.replied = true;
 
+    this.ephemeral = Boolean(data.flags & MessageFlags.Ephemeral);
+    this.replied = true;
     return options.fetchReply ? this.fetchReply() : new InteractionResponse(this);
   }
 
diff --git a/packages/discord.js/src/util/MessageFlagsBitField.js b/packages/discord.js/src/util/MessageFlagsBitField.js
index 71f1fd6c5c08..e6764b2fd791 100644
--- a/packages/discord.js/src/util/MessageFlagsBitField.js
+++ b/packages/discord.js/src/util/MessageFlagsBitField.js
@@ -23,6 +23,15 @@ class MessageFlagsBitField extends BitField {
  * @param {BitFieldResolvable} [bits=0] Bit(s) to read from
  */
 
+/**
+ * Data that can be resolved to give a message flags bit field. This can be:
+ * * A string (see {@link MessageFlagsBitField.Flags})
+ * * A message flag
+ * * An instance of {@link MessageFlagsBitField}
+ * * An array of `MessageFlagsResolvable`
+ * @typedef {string|number|MessageFlagsBitField|MessageFlagsResolvable[]} MessageFlagsResolvable
+ */
+
 /**
  * Bitfield of the packed bits
  * @type {number}
diff --git a/packages/discord.js/typings/index.d.ts b/packages/discord.js/typings/index.d.ts
index 8f7da19e47bc..e9982abc2013 100644
--- a/packages/discord.js/typings/index.d.ts
+++ b/packages/discord.js/typings/index.d.ts
@@ -2389,9 +2389,11 @@ export type MessageFlagsString = keyof typeof MessageFlags;
 
 export class MessageFlagsBitField extends BitField<MessageFlagsString> {
   public static Flags: typeof MessageFlags;
-  public static resolve(bit?: BitFieldResolvable<MessageFlagsString, number>): number;
+  public static resolve(bit?: MessageFlagsResolvable): number;
 }
 
+export type MessageFlagsResolvable = BitFieldResolvable<MessageFlagsString, number>;
+
 export class MessageMentions<InGuild extends boolean = boolean> {
   private constructor(
     message: Message,
@@ -2441,6 +2443,7 @@ export class MessagePayload {
   public get isWebhook(): boolean;
   public get isMessage(): boolean;
   public get isMessageManager(): boolean;
+  /** @deprecated This will no longer serve a purpose in the next major version. */
   public get isInteraction(): boolean;
   public files: RawFile[] | null;
   public options: MessagePayloadOption;
@@ -6351,15 +6354,23 @@ export interface InteractionCollectorOptions<
 }
 
 export interface InteractionDeferReplyOptions {
+  /** @deprecated Use {@link InteractionDeferReplyOptions.flags} instead. */
   ephemeral?: boolean;
+  flags?: BitFieldResolvable<
+    Extract<MessageFlagsString, 'Ephemeral' | 'SuppressEmbeds' | 'SuppressNotifications'>,
+    MessageFlags.Ephemeral | MessageFlags.SuppressEmbeds | MessageFlags.SuppressNotifications
+  >;
   fetchReply?: boolean;
 }
 
-export interface InteractionDeferUpdateOptions extends Omit<InteractionDeferReplyOptions, 'ephemeral'> {}
+export interface InteractionDeferUpdateOptions {
+  fetchReply?: boolean;
+}
 
 export interface InteractionReplyOptions extends BaseMessageOptionsWithPoll {
-  tts?: boolean;
+  /** @deprecated Use {@link InteractionReplyOptions.flags} instead. */
   ephemeral?: boolean;
+  tts?: boolean;
   fetchReply?: boolean;
   flags?: BitFieldResolvable<
     Extract<MessageFlagsString, 'Ephemeral' | 'SuppressEmbeds' | 'SuppressNotifications'>,