diff --git a/recipes/xmlsec/all/conanfile.py b/recipes/xmlsec/all/conanfile.py
index 97571ee991734b..33aa7afe74740d 100644
--- a/recipes/xmlsec/all/conanfile.py
+++ b/recipes/xmlsec/all/conanfile.py
@@ -140,7 +140,15 @@ def build(self):
             crypto_engines = []
             if self.options.with_openssl:
                 ov = Version(self.dependencies["openssl"].ref.version)
-                crypto_engines.append(f"openssl={ov.major}{ov.minor}0")
+                if ov.major >= "3":
+                    if Version(self.version) < "1.2.35":
+                        # configure.js doesn't understand openssl=300 before xmlsec 1.2.35,
+                        # For these xmlsec versions, setting 110 even for OpenSSL 3.x should be compatible
+                        crypto_engines.append("openssl=110")
+                    else:
+                        crypto_engines.append("openssl=300")
+                else:
+                    crypto_engines.append(f"openssl={ov.major}{ov.minor}0")
 
             yes_no = lambda v: "yes" if v else "no"
             args = [