diff --git a/CHANGELOG.md b/CHANGELOG.md
index 8779f789db4..e7e897393fa 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -31,6 +31,8 @@ release.
 - Clarify that the periodic metric reader is the default metric reader to be
   paired with push metric exporters (OTLP, stdout, in-memory)
   ([#2379](https://github.com/open-telemetry/opentelemetry-specification/pull/2379)).
+- Clarify that MetricReader has one-to-one mapping to MeterProvider.
+  ([#2406](https://github.com/open-telemetry/opentelemetry-specification/pull/2406)).
 
 ### Logs
 
diff --git a/specification/metrics/sdk.md b/specification/metrics/sdk.md
index 206f77d4d28..2f153daa379 100644
--- a/specification/metrics/sdk.md
+++ b/specification/metrics/sdk.md
@@ -652,6 +652,9 @@ that SDK will update the time range - e.g. from (T<sub>n</sub>, T<sub>n+1</sub>]
 to (T<sub>n+1</sub>, T<sub>n+2</sub>] - **ONLY** for this particular
 `MetricReader` instance.
 
+The SDK MUST NOT allow a `MetricReader` instance to be registered on more than
+one `MeterProvider` instance.
+
 ```text
 +-----------------+            +--------------+
 |                 | Metrics... |              |