diff --git a/packages/react/src/components/MultiSelect/MultiSelect.tsx b/packages/react/src/components/MultiSelect/MultiSelect.tsx
index ded2a65ff5ba..db5d76f96a5f 100644
--- a/packages/react/src/components/MultiSelect/MultiSelect.tsx
+++ b/packages/react/src/components/MultiSelect/MultiSelect.tsx
@@ -89,6 +89,10 @@ interface SortItemsOptions<ItemType>
   selectedItems: ItemType[];
 }
 
+interface selectedItemType {
+  text: string;
+}
+
 interface MultiSelectSortingProps<ItemType> {
   /**
    * Provide a compare function that is used to determine the ordering of
@@ -133,6 +137,11 @@ export interface MultiSelectProps<ItemType>
     > {
   className?: string;
 
+  /**
+   * Specify the text that should be read for screen readers that describes that all items are deleted
+   */
+  clearAnnouncement?: string;
+
   /**
    * Specify the text that should be read for screen readers that describes total items selected
    */
@@ -320,6 +329,7 @@ const MultiSelect = React.forwardRef(
       sortItems = defaultSortItems as MultiSelectProps<ItemType>['sortItems'],
       compareItems = defaultCompareItems,
       clearSelectionText = 'To clear selection, press Delete or Backspace',
+      clearAnnouncement = 'all items have been cleared',
       clearSelectionDescription = 'Total items selected: ',
       light,
       invalid,
@@ -349,6 +359,7 @@ const MultiSelect = React.forwardRef(
     const [isOpen, setIsOpen] = useState(open || false);
     const [prevOpenProp, setPrevOpenProp] = useState(open);
     const [topItems, setTopItems] = useState([]);
+    const [itemsCleared, setItemsCleared] = useState(false);
     const {
       selectedItems: controlledSelectedItems,
       onItemChange,
@@ -405,12 +416,17 @@ const MultiSelect = React.forwardRef(
             e.stopPropagation();
           }
 
+          if (!isOpen && match(e, keys.Delete) && selectedItems.length > 0) {
+            setItemsCleared(true);
+          }
+
           if (
             (match(e, keys.Space) ||
               match(e, keys.ArrowDown) ||
               match(e, keys.Enter)) &&
             !isOpen
           ) {
+            setItemsCleared(false);
             setIsOpenWrapper(true);
           }
         }
@@ -588,14 +604,18 @@ const MultiSelect = React.forwardRef(
       });
     }
 
+    const itemsSelectedText =
+      selectedItems.length > 0 &&
+      selectedItems.map((item) => (item as selectedItemType).text);
+
     return (
       <div className={wrapperClasses}>
         <label className={titleClasses} {...getLabelProps()}>
           {titleText && titleText}
           {selectedItems.length > 0 && (
             <span className={`${prefix}--visually-hidden`}>
-              {clearSelectionDescription} {selectedItems.length},
-              {clearSelectionText}
+              {clearSelectionDescription} {selectedItems.length}{' '}
+              {itemsSelectedText},{clearSelectionText}
             </span>
           )}
         </label>
@@ -701,6 +721,9 @@ const MultiSelect = React.forwardRef(
                 }
               )}
           </ListBox.Menu>
+          {itemsCleared && (
+            <span aria-live="assertive" aria-label={clearAnnouncement} />
+          )}
         </ListBox>
         {!inline && !invalid && !warn && helperText && (
           <div id={helperId} className={helperClasses}>